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Interaction of Yersinia pestis Virulence Factors with IL-1R/TLR Recognition System

  • Vyacheslav M. Abramov
  • Valentin S. Khlebnikov
  • Anatoly M. Vasiliev
  • Igor V. Kosarev
  • Raisa N. Vasilenko
  • Nataly L. Kulikova
  • Vladimir L. Motin
  • Georgy B. Smirnov
  • Valentin I. Evstigneev
  • Nicolay N. Karkischenko
  • Vladimir N. Uversky
  • Robert R. Brubaker
Conference paper
Part of the Infectious Disease book series (ID)

22.1 Introduction

The innate immunity is the first line of defense recognizing commensals and pathogenic microorganisms (1, 2). Innate immune responses derive from the ability of cells to rapidly combat invading microorganisms without the requirement for an antigen-specific adaptation. These mechanisms have evolved to recognize common microbe-associated molecular patterns and to interfere with conserved replication and survival strategies that support the propagation of microbial invaders. Toll-like receptors (TLRs) perform the recognition functions. Interleu-kin (IL)-1 and IL-18 receptors also belong to the TLR family. TLRs are critical proteins linking innate and acquired immunity (3). In the evolutionary process of host-parasite interrelations, pathogenic microorganisms had been armed with virulence factors specifically interacting with TLRs to manage the innate immunity and evade immunological control. Y. pestis, a causative agent of bubonic and pneumonic plague, inherited...

Keywords

U937 Cell Capsular Antigen Soluble Decoy Receptor Pneumonic Plague Bubonic Plague 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Vyacheslav M. Abramov
    • 1
  • Valentin S. Khlebnikov
    • 1
  • Anatoly M. Vasiliev
    • 1
  • Igor V. Kosarev
    • 1
  • Raisa N. Vasilenko
    • 1
  • Nataly L. Kulikova
    • 1
  • Vladimir L. Motin
    • 2
  • Georgy B. Smirnov
    • 3
  • Valentin I. Evstigneev
    • 1
  • Nicolay N. Karkischenko
    • 4
  • Vladimir N. Uversky
    • 1
  • Robert R. Brubaker
    • 5
  1. 1.Department of Biochemistry of Immunity and BiodefenseInstitute of Immunological EngineeringLyubuchanyRussia
  2. 2.Departments of Pathology/Microbiology and ImmunologyUniversity of Texas Medical BranchGalvestonUSA
  3. 3.The Gamaleya Institute of Epidemiology and MicrobiologyMoscowRussia
  4. 4.Scientific Center of Biomedical Technologies RAMSRussia
  5. 5.Department of Microbiology and Molecular GeneticsMichigan State UniversityEast LansingUSA

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