Therapy for Patients not Eligible for Autologous Transplant

  • Bringhen Sara
  • Palumbo Antonio
Part of the Contemporary Hematology book series (CH)


High-dose therapy supported by autologous stem cell transplant is considered a category 1 recommendation for newly diagnosed multiple myeloma (MM) patients.1 Currently, MM is the most common indication for autologous transplant, with ~ 4,500 transplants performed yearly in North America (Center for International Blood and Marrow Transplant Research [CIBMTR] data) and 5,300 in Europe.2Therefore, one of the first steps in choosing an initial therapy for symptomatic MM patients is to determine whether they would be candidates for stem cell transplant. The criteria to define eligibility for stem cell transplant include comorbidities, age, and performance status. Abnormal cardiac, pulmonary, renal, and liver functions are generally considered exclusion criteria for transplant protocols. Sixty-five years of age is commonly the higher limit age used to define eligible patients. However, it should be noted that advanced age and renal dysfunction are not absolute...


Overall Survival Multiple Myeloma Peripheral Neuropathy Maintenance Therapy Induction Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Supported in part by the Universitá degli Studi di Torino, Fondazione Neoplasie Sangue Onlus, Associazione Italiana Leucemie, Compagnia di S Paolo, Fondazione Cassa di Risparmio di Torino, Ministero dell'Universitá della Ricerca (MIUR), and Consiglio Nazionale delle Ricerche (CNR), Italy.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Bringhen Sara
    • 1
  • Palumbo Antonio
    • 1
  1. 1.Divisione di Ematologia dell'Universita di TorinoItaly

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