Biology-Based Classification and Staging of Multiple Myeloma

  • Wee Joo Chng
  • Peter Leif Bergsagel
Part of the Contemporary Hematology book series (CH)


While staging in solid tumor describes the anatomical spread of the tumor, for example, to the lymph nodes or distant sites, this concept is not applicable to hematological malignancies as the malignant cells by default are already distributed throughout the body. In hematological malignancies such as multiple myeloma (MM), an incurable late B-cell malignancy characterized by bone marrow infiltration with malignant plasma cells (PCs), and lytic bone lesions, staging provides a measure of how advance the tumor is and often reflects tumor burden.

There is a close link between disease stage and prognosis, and in hema-tological malignancies, prognostic systems are often built around factors that reflect disease stage. As such staging system and prognostic system are synonymous. Ultimately, the importance of staging and classification is in the ability to define clinically relevant heterogeneity within a tumor type and their clinical utility as guide to treatment decision and...


Multiple Myeloma Median Overall Survival 17p13 Deletion Centrosome Amplification International Stage System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Wee Joo Chng
    • 1
  • Peter Leif Bergsagel
    • 1
  1. 1.Mayo Clinic Comprehensive Cancer CenterScottsdaleUSA

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