POEMS Syndrome and Other Atypical Plasma Cell Disorders

  • Angela Dispenzieri
Part of the Contemporary Hematology book series (CH)

Atypical PCD Associated with Peripheral Neuropathy as Dominant Phenotype

Other important peripheral neuropathies (PNs)-associated plasma cell disorders (PCDs) include those induced by chemotherapy and those related to Waldenström macroglobulinemia, multiple myeloma, and light-chain amyloid, but these are beyond the scope of this chapter. Disorders like cryoglob-ulinemia, scleromyxedema can also be associated with PN, but those entities will be reviewed in later sections since PN is not their dominant phenotype. In this section, the focus will be on POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome and MGUS (mono-clonal gammopathy of undetermined significance)-associated PN.

POEMS Syndrome

The complexity of the interaction with plasma cell dyscrasia and PN became increasingly evident in 1956 with Crow's description of two patients with osteosclerotic plasmacytomas with neuropathy, and other “striking features,” which included clubbing, skin...


Vascular Endothelial Growth Factor Multiple Myeloma Vascular Endothelial Growth Factor Level Monoclonal Gammopathy Chronic Inflammatory Demyelinating Polyneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Financial support: AD was supported in part by grants CA125614, CA062242, CA107476, CA15083, and CA11345 from the National Cancer Institute. Financial disclosures: Clinical trial support from Celgene, Cytogen, Neurochem.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Angela Dispenzieri
    • 1
  1. 1.Division of Hematology, Mayo ClinicRochesterUSA

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