AL (Immunoglobulin Light-Chain) Amyloidosis

  • Vaishali Sanchorawala
Part of the Contemporary Hematology book series (CH)


The amyloidoses are a group of diseases that have in common the extracellular deposition of pathologic, insoluble fibrils in various tissues and organs. The fibrils have a characteristic beta-pleated sheet configuration that produces apple-green birefringence under polarized light when stained with Congo red dye. 1 Many different proteins can misfold and form amyloid fibrils, and the types of amy-loidosis are classified based on the amyloidogenic protein as well as by the distribution of amyloid deposits as either systemic or localized. 2 In the systemic amyloidoses, the amyloidogenic protein is produced at a site distant from the site of amyloid deposition. In contrast, in localized disease, the amyloidogenic protein is produced at the site of amyloid deposition (Table 1).
Table 1

Types of amyloidosis.


Precursor protein

Amyloid protein


Systemic disease


AL amyloidosis

Immunoglobulin light chain



AA amyloidosis

Serum amyloid A (SAA)





Multiple Myeloma Amyloid Deposit Amyloid Fibril Cardiac Amyloidosis Hematologic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Vaishali Sanchorawala
    • 1
  1. 1.Boston University Medical CenterBostonUSA

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