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Management of Multiple Myeloma Patients with Renal Dysfunction

  • Sikander Ailawadhi
  • Chanan-Khan Asher
Part of the Contemporary Hematology book series (CH)

Introduction

Multiple myeloma (MM) is a systemic disorder with ability to affect multiple organ systems including the renal system. Renal dysfunction is an important complication in patients with MM that can result in a limitation of therapeutic options and is associated with a compromised survival. 1 Among newly diagnosed MM patients, ~50% are noted to have a decrease in creatinine clearance (Cr Cl) while 10% of the patients will require dialysis due to severe renal impairment. 2 The incidence of renal failure in MM patients differs among various reported series depending on the criteria used to define renal failure as well as the patient population studied. Among the MM patients who present with renal dysfunction on initial presentation, at least 20% can be classified as having renal failure defined by an increase ≥2.0 mg/dL (177 micromole/L) in serum creatinine concentrations. 3In a series of 66 MM patients at Roswell Park Cancer Institute we used the National Kidney Foundation's...

Keywords

Multiple Myeloma Light Chain Renal Dysfunction Overall Response Rate Continuous Ambulatory Peritoneal Dialysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Dr. Edit Weber, Department of Pathology, Buffalo General Hospital, Buffalo, N Y.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sikander Ailawadhi
    • 1
  • Chanan-Khan Asher
    • 1
  1. 1.Department of MedicineRoswell Park Cancer InstituteBuffaloUSA

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