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Anemia and Erythropoeitic Growth Factors in Multiple Myeloma

  • Mark J Sloan
  • Noopur Raje
Part of the Contemporary Hematology book series (CH)

Introduction

multiple myeloma (MM) is characterized by a clonal proliferation of plasma cells within the bone marrow compartment. Anemia is a common feature of MM and its presence often dictates the need for treatment. The proper management of anemia in MM can impact both the duration and the quality of life in myeloma patients. This chapter will focus on the prevalence, patho-physiology, and management of anemia associated with MM. Special attention will be paid to the use of erythropoietic growth factors in MM.

Prevalence and Severity of Anemia in Multiple Myeloma

Virtually no myeloma patient is exempt from the complication of anemia; of 1027 patients diagnosed with MM at the Mayo Clinic between 1985 and 1998, 73% were anemic at diagnosis and 97% had a hemoglobin (Hb) level of 12 g/dL or lower at some point in the course of their disease.1 A 7% minority of patients had an Hb level of < 8 g/dL at presentation. A similar prevalence was documented in the European Cancer Anaemia Survey.2...

Keywords

Multiple Myeloma Darbepoetin Alfa Erythropoietin Level Malignant Plasma Cell Erythropoietin Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Mark J Sloan
  • Noopur Raje
    • 1
  1. 1.Dana-Farber Cancer InstituteBostonUSA

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