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Histone Deacetylase Inhibitors in Multiple Myeloma

  • Teru Hideshima
Part of the Contemporary Hematology book series (CH)

Histones and Histone Decaetylases

Histones are the main protein components of chromatin and have been found in the nuclei of all eukaryotic cells where they are complexed to DNA in chromatin and chromosomes. Histones are of relatively low molecular weight (10–20 kD) and can be grouped into five major classes. Two copies of H2A, H2B, H3, and H4 bind to about 200 base pairs of DNA to form the repeating structure of chromatin, the nucleosome, with H1 binding to the linker sequence. During transcription, the transcription factors have to bind to their specific binding site in the promoter region of DNA. When the DNA is in compact form, it is often difficult for proteins to access DNA, thereby limiting transcription. In contrast, when DNA is bundled into chromosomes, histones play a major role in restricting the binding of transcription factors to DNA. In activation of histones, the acetylation status of amino-terminus is crucial in their binding process to DNA. It is regulated by the...

Keywords

Multiple Myeloma Chronic Lymphocytic Leukemia Maximum Tolerate Dose HDAC Inhibitor Hydroxamic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Teru Hideshima
    • 1
  1. 1.Department of Medical Oncology, Jerome Lipper Multiple Myeloma CenterDana-Farber Cancer Institute and Harvard Medical SchoolBostonUSA

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