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Lenalidomide in Relapsed or Refractory Multiple Myeloma

  • Sheeba K. Thomas
  • Tiffany A. Richards
  • Donna M. Weber
Part of the Contemporary Hematology book series (CH)

Introduction

Until the late-1990s, combinations of alkylating agents, steroids, and anthracyclines formed the basis of therapy for patients with multiple myeloma (MM), with regimens such as melphalan—prednisone, high-dose dexamethasone, and VAD (vincristine, Adriamycin®, dexamethasone) providing partial response (PR) rates of up to 55% and complete response (CR) rates of up to 10% in previously untreated patients.1, 2, 3 Among patients with either primary refractory or relapsing myeloma, only 25–40% achieved PR with these regimens, and rates of CR were negligible.4,5 The introduction of thalidomide in 1999 began a new era of agents effective for the treatment of MM, with single-agent response rates of 28–36% in relapsing/refractory patients.6, 7, 8, 9 When given together with dexamethasone, response rates approximated 47–55% in this population.7,10, 11, 12More recently, lenal-idomide, an analogue of thalidomide, has emerged, and is associated with single-agent response rates of...

Keywords

Vascular Endothelial Growth Factor Multiple Myeloma Maximum Tolerate Dose Myeloma Cell Partial Response Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sheeba K. Thomas
    • 1
  • Tiffany A. Richards
    • 1
  • Donna M. Weber
  1. 1.Anderson Cancer CenterHoustonUSA

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