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Thalidomide in Patients with Relapsed Multiple Myeloma

  • Ashraf Badros
Part of the Contemporary Hematology book series (CH)

The Dark Remedy “History of Thalidomide”

More than half a century ago, thalidomide began an astonishing journey of endurance where fate rather than science transformed a dreadful drug to a great remedy.1,2In 1953, a chemist at a German pharmaceutical company, Chemie Grünenthal, first synthesized thalidomide after heating a commercially available chemical phthaloylisoglutamine; the new molecule was called thalid-omide. The company patented the molecule and began searching for diseases thalidomide could treat. In absence of any scientific rationale, human clinical trials began. However, after extensive testing, they failed to establish pharmacological activity as an antibiotic, an anticonvulsant, or an antihistaminic. It is worth mentioning that thalidomide was evaluated in two clinical trials including 92 patients with advanced cancer, including two patients with multiple myeloma (MM). Many patients reported palliation of symptoms. However, with the lack of clinical responses, the...

Keywords

Vascular Endothelial Growth Factor Overall Survival Multiple Myeloma Peripheral Neuropathy Hepatocyte Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ashraf Badros
    • 1
  1. 1.Greenebaum Cancer CenterUniversity of MarylandBaltimoreUSA

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