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Equality of the Sexes? Parent-of-Origin Effects on Transcription and de novo Mutations

  • Rivka L. GlaserEmail author
  • Ian M. Morison

Abstract

Two main categories of the parent-of-origin effects are reviewed in this chapter: parent-of-origin effects on transcription, or genomic imprinting, and parent-of-origin effects on the development of de novo mutations. Each type of parent-of-origin effect is described, and the mechanisms that contribute to each discussed. The parent-of-origin effect database provides a catalog reports of genomic imprinting and related effects as well as reports of the parental origin of spontaneous mutations. This database provides a useful tool for finding genes, diseases, or traits that exhibit a parent-of-origin effect in humans and animals, conducting comparative analyses of the imprinted genes among different species, and examining the role of parent-of-origin effects for different types of spontaneous mutations in human genes.

Keywords

Parental origin Genomic imprinting de novo mutations Transcription 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Biological SciencesStevenson UniversityStevensonUSA
  2. 2.University of OtagoNew Zealand

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