Proteomics of Human Body Fluids

pp 399-414

Proteomics of Human Bile

  • Troels Zakarias KristiansenAffiliated withMcKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins UniversityDepartment of Biochemistry and Molecular Biology, University of Southern Denmark
  • , Anirban MaitraAffiliated withMcKusick-Nathans Institute of Genetic Medicine, The Sol Goldman Pancreatic Cancer Research Center, and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University
  • , Akhilesh PandeyAffiliated withMcKusick-Nathans Institute of Genetic Medicine, and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University

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Bile is an important body fluid with crucial functions ranging from fat absorption to excretion of metabolic breakdown products. Although the chemical composition of human bile is well understood, its protein constituents are beginning to be unravelled only recently. Here, we provide an overview of the proteomics of human bile, both in health and in diseases such as cholangiocarcinoma. A comprehensive catalog of proteins in the bile should facilitate better understanding of its role in physiology and the development and validation of biomarkers for hepatobiliary disorders.

Key Words

Bile LC-MS/MS proteomics biomarker discovery mass spectrometry hepatobiliary cancer