Proteomics of Human Pancreatic Juice

  • Mads Grønborg
  • Anirban Maitra
  • Akhilesh Pandey

Abstract

Pancreatic juice has recently been characterized in detail using proteomic methods. The cataloging of proteins from healthy individuals and those diagnosed with pancreatic cancer has revealed the presence of a number of proteins in pancreatic juice that could serve as potential biomarkers for cancer. Because obtaining pancreatic juice is not trivial, it is possible that these biomarkers can be detected in serum using more sensitive methods like ELISA. Here, we discuss the protein constituents of pancreatic juice with special reference to cancer biomarkers.

Key Words

Pancreatic juice LC-MS/MS quantitative proteomics biomarker discovery mass spectrometry 

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Copyright information

© Humana Press Inc., Totowa, NJ 2007

Authors and Affiliations

  • Mads Grønborg
    • 1
    • 2
  • Anirban Maitra
    • 3
  • Akhilesh Pandey
    • 4
  1. 1.McKusick-Nathans Institute of Genetic Medicine and Department of Biological ChemistryJohns Hopkins UniversityBaltimore
  2. 2.Department of Biochemistry and Molecular BiologyUniversity of Southern DenmarkOdense MDenmark
  3. 3.McKusick-Nathans Institute of Genetic Medicine, The Sol Goldman Pancreatic Cancer Research Center, and Departments of Biological Chemistry, Pathology and OncologyJohns Hopkins UniversityBaltimore
  4. 4.McKusick-Nathans Institute of Genetic Medicine, and Departments of Biological Chemistry, Oncology and PathologyJohns Hopkins UniversityBaltimore

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