Electrophysiological Measurements of Membrane Proteins

  • Tsung-Yu Chen
  • Yu-Fung Lin
  • Jie Zheng
Chapter
Part of the Handbook of Modern Biophysics book series (HBBT)

Ion channels and transporters are macromolecular proteins in the cell membrane that consist of ion transport pathways in the protein structure. These membrane proteins catalyze ion flux across lipid membranes and thus generate currents that flow into or out of cells. By altering electric currents through cell membranes, ion channels and transporters control the membrane potential, an important property of living cells [1]. In addition, the ions that flow into cells (for example, Ca2+ ions) may play significant roles as intracellular messengers, and thus are critical for signal transduction mechanisms in cells [2]. A defect in ion transport can result in a variety of cellular malfunctions that cause many human diseases [3].

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Further Study

  1. Hille, B. 2001. Ion channels of excitable membranes. Sunderland, MA: Sinauer Associates.Google Scholar
  2. Sakmann B, Neher E. 1983. Single-channel recording, 1st ed. New York: Plenum.Google Scholar
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  5. Ashcroft F. 2000. Ion channels and diseases: channelopathies. London: Academic.Google Scholar
  6. Lakowicz J. 2006. Principles of fluorescence spectroscopy. 3rd ed. New York: Springer.CrossRefGoogle Scholar

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Copyright information

© Humana Press 2009

Authors and Affiliations

  • Tsung-Yu Chen
    • 1
    • 2
  • Yu-Fung Lin
    • 3
    • 4
  • Jie Zheng
    • 4
  1. 1.Center for NeuroscienceUniversity of CaliforniaDavis
  2. 2.Departments of NeurologyUniversity of CaliforniaDavis
  3. 3.Anesthesiology,University of CaliforniaDavis
  4. 4.Physiology and Membrane BiologyUniversity of CaliforniaDavis

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