Long-Term Sequelae of Polycystic Ovary Syndrome

Association With Insulin Resistance and the Metabolic Syndrome
  • Richard S. Legro
Part of the Contemporary Endocrinology book series (COE)


Insulin resistance is associated with reproductive abnormalities in women with polycystic ovary syndrome (PCOS) including hyperandrogenemia, anovulation, and polycystic ovaries, as well as long-term risk for developing diabetes and most likely also for cardiovascular disease (CVD) and endometrial cancer. There is emerging evidence of increased subclinical CVD in women with PCOS. But it may not be apparent until the perimenopause. Currently there are scant data that markers of insulin resistance predict response to treatment. Therefore, the role of these markers in selecting and following response to specific treatments is uncertain.

Further research that examines the long-term effects of improving insulin resistance on such important clinical endpoints as the development of diabetes, overt CVD, and endometrial cancer are needed.

Key Words

PCOS Insulin resistance metabolic syndrome cardiovascular disease endometrial carcinoma 


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Richard S. Legro
    • 1
  1. 1.Department of Obstetrics and GynecologyPennsylvania State University College of MedicineHershey

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