Deproteinized Bovine Bone Xenograft

  • Andreas Stavropoulos
Part of the Orthopedic Biology and Medicine book series (OBM)


Deproteinized bovine bone (DBB) has a chemical composition and architectural geometry that is almost identical to that of human bone and can support new bone formation in direct contact to the graft. DBB grafts are widely used in dentistry in a variety of applications, and positive results have been generally observed after their application. However, an added clinical benefi t from their use in association with dental implants and/or when used as adjuncts to guided tissue regeneration (GTR) in the treatment of periodontal intrabony defects cannot unequivocally be confi rmed. It seems that DBB should be regarded as an osteocompatible fi ller material that may act as a space provision device rather than as a bone promoting substance, and the outcome of DBB grafting in terms of bone fill seems greatly dependent on the confi guration and dimensions of the defect. Relevant in vitro and animal experiments, as well as human clinical studies in a variety of applications, are presented and discussed. The chapter also briefly describes the processing method of xenograft bone and its properties, and discusses the risk of disease transmission.


Bone bovine devitalized deproteinized grafts GTR implants osteoconduction periodontology regeneration xenograft xenotransplantation 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Andreas Stavropoulos
    • 1
  1. 1.Department of Periodontology and Oral Gerontology, School of DentistryUniversity of AarhusDenmark

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