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Electrical Manipulation of DNA on Metal Surfaces

  • Marc Tornow
  • Kenji Arinaga
  • Ulrich Rant

Abstract

We review recent work on the active manipulation of DNA on metal substrates by electric fields. This includes the controlled positioning, alignment, or release of DNA on or into dedicated locations and the control of hybridization. In this context, we discuss techniques for immobilizing DNA on metal surfaces and methods of characterizing such hybrid systems. In particular, we focus on electrically induced, conformational changes of monolayers of short oligonucleotides on gold substrates. Such switchable layers allow for molecular dynamics studies at interfaces and have demonstrated large potential in label-free biosensing applications.

Key Words

Biomolecular films biosensors conformational changes DNA-basedsensing molecular dynamics nano-electromechanical system (NEMS) oligonucleotides self-assembled monolayers surface functionalization switchable layer 

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Copyright information

© Humana Press Inc., Totowa, NJ 2008

Authors and Affiliations

  • Marc Tornow
    • 1
  • Kenji Arinaga
    • 2
    • 3
  • Ulrich Rant
    • 2
  1. 1.Institute of Semiconductor TechnologyTechnical University of BraunschweigBraunschweigGermany
  2. 2.Walter Schottky InstitutTechnische Universitaet MuenchenGarchingGermany
  3. 3.Fujitsu Laboratories Ltd.AtsugiJapan

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