Intraperitoneal Cancer Therapy pp 71-100
Hyperthermia and Chemotherapy: The Science
Cancer ranks second only to heart disease as the greatest cause of mortality in the United States. Despite significant strides in diagnosis and therapeutics, clinical treatment of metastatic cancer still yields a poor prognosis. Basic science research is increasing our knowledge of the mechanisms by which chemotherapeutic and hyperthermic modalities exert their antitumor activity. Herein, we describe the current state of knowledge of these treatment modalities and the basic science behind their clinical usefulness. Moreover, we identify gaps in our understanding of the basic science of these treatments. Basic science is primed to exert a substantial role in extending our therapeutic options through the clarification of current therapeutic mechanisms, as well as the generation of novel treatments.
Key WordsCancer neoplasia metastasis chemotherapy hyperthermia
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