Antibiotic Resistance Due to Reduced Uptake

  • Joseph B. McPhee
  • Sandeep Tamber
  • Michelle D. Brazas
  • Shawn Lewenza
  • Robert E. W. Hancock
Part of the Infectious Disease book series (ID)

The introduction of antibiotic therapy for the treatment of bacterial infections has led to a greatly increased human lifespan compared to that in the pre-antibiotic era. However, a disturbing trend has also been noted in that, within a very short period of time following the introduction of a new antibiotic, resistance to that antibiotic begins to emerge, a factor that is becoming increasingly meaningful as the discovery of new antibiotics wanes (1-3). There are a number of mechanisms by which a bacterium may become resistant to a particular antibiotic. Generally these include, but are not limited to, modifi cation of the drug to render it inactive, modifi cation of the drug target, such that it is incapable of interacting with the drug and decreased uptake of the antibiotic into the cell, due to reduced transport and/or increased effl ux. Recent functional genomic studies have also implied that antibiotics may have more complex mechanisms of action than fi rst thought and we are beginning to appreciate that in addition to the mutation of primary targets, subtle mutations in secondary targets are likely to be infl uential (4, 5). This chapter will focus on the contribution of a decreased antibiotic uptake to an increase in antibacterial resistance.


Outer Membrane Divalent Cation Cytoplasmic Membrane Antimicrob Agent Capsular Polysaccharide 
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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Joseph B. McPhee
    • 1
  • Sandeep Tamber
    • 2
  • Michelle D. Brazas
    • 3
  • Shawn Lewenza
    • 4
  • Robert E. W. Hancock
    • 5
  1. 1.Postdoctoral Fellow, Center for Infectious DiseaseState University of New York — Stony BrookStony BrookUSA
  2. 2.Postdoctoral Fellow, Dartmouth College Medical SchoolDartmouth CollegeHanoverUSA
  3. 3.Bioinformatics Education, Research AssociateOntario Institute for Cancer ResearchTorontoCanada
  4. 4.Department of Microbiology and Infectious DiseasesUniversity of CalgaryCalgaryCanada
  5. 5.Centre for Microbial Diseases and Immunity ResearchUniversity of British ColumbiaVancouverCanada

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