Thyroid Cancer pp 179-198 | Cite as

False-Positive Radioiodine Scans in Thyroid Cancer

  • Brahm Shapiro
  • Vittoria Rufini
  • Ayman Jarwan
  • Onelio Geatti
  • Kimberlee J. Kearfott
  • Lorraine M. Fig
  • Ian D. Kirkwood
  • John E. Freitas
  • Milton D. Gross


The whole-body radioiodine scan remains an important component in the postoperative treatment of patients with well-differentiated thyroid cancer. Because normal thyroid tissue remnants and residual or metastatic foci of well-differentiated thyroid cancer have the unique ability to concentrate, organify, and store radioiodine, the wholebody scan provides a depiction of those tissues that can be ablated with therapeutic doses of radioiodine. Over time, it has become obvious that the whole-body scan may also reveal foci of radioiodine accumulation from a wide variety of other causes. This chapter provides an update of an article in the Seminars of Nuclear Medicine* in 2000 that detailed the pathophysiological classification of artifacts, anatomic and physiological variants, and nonthyroidal diseases that may give rise to false-positive whole body scans in postoperative patients with thyroid cancer.


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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Brahm Shapiro
    • 1
  • Vittoria Rufini
    • 2
  • Ayman Jarwan
    • 3
  • Onelio Geatti
    • 4
  • Kimberlee J. Kearfott
    • 3
  • Lorraine M. Fig
    • 5
  • Ian D. Kirkwood
    • 6
  • John E. Freitas
    • 7
    • 8
  • Milton D. Gross
    • 9
    • 10
  1. 1.Division of Nuclear Medicine, Department of RadiologyUniversity of Michigan Medical CenterAnn Arbor
  2. 2.Instutito di Medicina NucleareUniversita Cattolica del Sacro CuoreRomeItaly
  3. 3.Department of Nuclear Engineering and Radiological SciencesUniversity of MichiganAnn Arbor
  4. 4.Servizio di Medicina NucleareOspedale MaggioreTriesteItaly
  5. 5.Nuclear Medicine ServiceDepartment of Veterans Affairs Health SystemAnn Arbor
  6. 6.Department of Nuclear MedicineRoyal Adelaide HospitalNorth TerraceAustralia
  7. 7.Nuclear Medicine Services, Department of RadiologySt. Joseph Mercy HospitalAnn Arbor
  8. 8.University of Michigan Medical SchoolAnn Arbor
  9. 9.Division of Nuclear Medicine, Department of RadiologyUniversity of Michigan Medical School
  10. 10.Nuclear Medicine and Radiation Safety ServiceDepartment of Veterans Affairs Health SystemsWashington, DC (field based) and Ann Arbor

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