Echocardiographic Assessment of Diastolic Function

  • Carolyn Y. Ho
Part of the Contemporary Cardiology book series (CONCARD)


Diastole is the portion of the cardiac cycle that spans from isovolumic ventricular relaxation to the Her exercise tolerance has been slowly declining completion of antegrade mitral flow. There are four distinct phases of diastole (Fig. 1): (1) isovolumetric ventricular relaxation: an active, adenosine triphosphate (ATP)-requiring process that occurs from end-systole until left ventricular pressure falls below left arterial pressure leading to mitral valve (MV) opening; (2) rapid early ventricular filling: blood flows from left atrium (LA) into the left ventricle (LV) during continued, active, then passive LV relaxation; (3) diastasis: active ventricular relaxation is completed and near equilibration of LA and LV pressures occurs with resultant slow LA filling from pulmonary venous (PV) flow; and (4) atrial systole: increased transmitral pressure gradient from atrial contraction results in acceleration of blood flow from LA to LV.


Left Atrium Diastolic Dysfunction Diastolic Function Constrictive Pericarditis Mitral Inflow 
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Copyright information

© Humana Press Inc., Totowa, NJ 2007

Authors and Affiliations

  • Carolyn Y. Ho
    • 1
  1. 1.Cardiovascular Genetics Center, Cardiovascular Division, Brigham and Women’s HospitalHarvard Medical SchoolBoston

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