Haplotype Structure of the Mouse Genome
Commonly available inbred mouse strains can be used to genetically model traits that vary in the human population, including those associated with disease susceptibility. In order to understand how genetic differences regulate trait variation in humans, we must first develop a detailed understanding of how genetic variation in the mouse produces the phenotypic differences among inbred mouse strains. The information obtained from analysis of experimental murine genetic models can direct biological experimentation, clinical research, and human genetic analysis. This “mouse to man” approach will increase our knowledge of the genes and pathways regulating important biological processes and disease susceptibility.
KeywordsMouse Genome Inbred Strain Haplotypic Block Inbred Mouse Allelic Difference
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