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Platelets and Inflammation

  • Meinrad Gawaz
Chapter
  • 1.1k Downloads
Part of the Contemporary Cardiology book series (CONCARD)

Abstract

Platelets play a major physiological role in control of vascular integrity at the site of vascular lesions. However, the pathophysiological role of platelets is much broader than regulation of hemostasis and thrombosis. Platelets are critical elements in linking and modulating thrombosis, inflammation, and tissue repair. Platelets are stimulated by a variety of agonists including thrombin or ADP and also by inflammatory agents such as antibodies, complement, bacteria, and others. Platelets contribute to inflammation by interacting with inflammatory cells via adhesion and secretion of prestored proinflammatory mediators. Thus, platelets are critical elements in the pathophysiology of inflammation and modulate significantly a variety of inflammatory diseases. A profound understanding of the molecular mechanisms underlying the role of platelet in inflammation may result in new therapeutic strategies in acute and chronic inflammatory diseases.

Keywords

Platelet Adhesion Adhesion Receptor Tissue Factor Expression Junctional Adhesion Molecule Vitronectin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Meinrad Gawaz
    • 1
  1. 1.Medizinische Universitätsklinik und Poliklinik, Klinikum auf dem SchnarrenbergUniversität TübingenTübingenGermany

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