Nutrition and Bone Health pp 211-226 | Cite as
Nutrition and Bone Health in the Elderly
Abstract
Osteoporosis, a common disorder of women and men, is associated with significant morbidity, mortality, and health care costs. Age-related fractures are the most common manifestation of osteoporosis and are usually manifested after menopause in women, and in the seventh or eighth decade in men. Biochemical, biomechanical, and nonskeletal factors contribute to fragility fractures in the elderly. However, nutritional determinants also play a key role in both the pathophysiology and treatment of individuals with osteoporosis. Traditionally, calcium has been considered the key nutrient for optimal skeletal growth and maintenance. However, recent evidence has emerged linking vitamins D, K, and A to the pathogenesis of osteoporosis, especially in elderly individuals. Additionally, adequate protein intake is essential for bone formation, particularly in vulnerable populations residing in nursing homes and assisted-living facilities. Preservation of skeletal architecture is also dependent on maintenance of muscle mass, another soft tissue component that is influenced by nutrient intake. This chapter will focus on the skeletal and nonskeletal pathways that contribute to fractures in the older individual and the role of nutrition in treating and preventing age-related osteoporosis. However, it should be noted that the pathogenesis of skeletal frailty is complex and centers on the entire organism, not just bone. For example, fractures generally result from falls; falling can be related to poor muscle strength, which in turn can be strongly influenced by nutritional intake.
Keywords
Bone Mineral Density Bone Loss Bone Resorption Bone Health Adequate Protein IntakePreview
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References
- 1.Rosen CJ. Restoring aging Bones. Sci Am 2003; 288:70–78.PubMedCrossRefGoogle Scholar
- 2.Robey PB, Bianco P. Cellular mechanism of age related bone loss. In: Rosen CJ, Glowacki J, Bilezikian JP, eds. The Aging Skeleton. Academic Press, San Diego, CA, 1999, pp. 145–157.CrossRefGoogle Scholar
- 3.Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998; 93(2):165–176.PubMedCrossRefGoogle Scholar
- 4.Martin TJ, Ng KW. Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. J Cell Biochem 1994; 56:357–366.PubMedCrossRefGoogle Scholar
- 5.Donahue LR, Rosen CJ. IGFs and bone: the osteoporosis connection revisited. Proc Soc Exp Biol Med 1998; 219:1–7.PubMedGoogle Scholar
- 6.Beamer WG, Donahue LR, Rosen CJ. IGF-I and bone: from mouse to man. International Symposium on GH and Growth Factors in Endocrinology and Metabolism; Growth Hormone and IGF Research 2000, 6:B S103–S105.CrossRefGoogle Scholar
- 7.Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the IGFs. Endocrinol Rev 1994; 15:80–101.Google Scholar
- 8.Musey VC, Goldstein S, Farmer PK, Moore PB, Phillips LS. Differential regulation of IGF-I and IGFBP-1 by dietary composition in humans. Am J Med Sci 1993; 305:131–138.PubMedCrossRefGoogle Scholar
- 9.Ketelslegers JM, Maiter D, Maes M, Underwood LD, Thissen JP. Nutritional regulation of IGF-I. Metabolism 1995; 44:50–57.PubMedCrossRefGoogle Scholar
- 10.Rosen CJ, Kessenich C. The role of IGF-I in senesence: implications for therapy. Endocrinologist. 1996; 6:102–106.CrossRefGoogle Scholar
- 11.Heaney RP, McCarron DA, Dawson-Hughes B, et al. Dietary changes favorably affect bone remodeling. J Am Diet Assoc 1999; 99:1228–1233.PubMedCrossRefGoogle Scholar
- 12.Tkatch L, Rapin CH, Rizzoli R, et al. Benefits of oral protein supplement in elderly patients with fracture of the proximal femur. J Am Coll Nutr 1992; 11:619–523.Google Scholar
- 13.Schurch MA, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour JP. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998; 128(10):801–890.PubMedGoogle Scholar
- 14.Boonen S, Rosen C, Bouillon R, et al. Musculoskeletal effects of the rhIGF-I/IGFBP-3 complex in osteoporotic patients with proximal femoral fracture. J Clin Endocrinol Metab 2002; 87:1593–1599.PubMedCrossRefGoogle Scholar
- 15.Prince RL. The rationale of calcium supplementation in the therapeutics of age related osteoporosis. In: Rosen CJ, Glowacki J, Bilezikian JP, eds. The Aging Skeleton. Academic, San Diego, CA, 1999, pp. 479–494.CrossRefGoogle Scholar
- 16.Gloth FM. Vitamin D. In: Rosen CJ, Glowacki J, Bilezikian JP, eds. The Aging Skeleton. Academic, San Diego, CA, 1999, pp. 185–194.CrossRefGoogle Scholar
- 17.Riggs BL, Wahner W, Seeman E, et al. Changes in bone mineral density of the proximal femur and spine with aging: differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest 1982; 70:716–723.PubMedCrossRefGoogle Scholar
- 18.Ensrud KE, Palermo L, Black DM, et al. Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures. J Bone Miner Res 1995; 10:1778–1787.PubMedCrossRefGoogle Scholar
- 19.Hannan MT, Felson DT, Dawson-Hughes B, et al. Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 2000; 15:710–720.PubMedCrossRefGoogle Scholar
- 20.Ensrud KE, Palmero L, Black MD, et al. Hip and calcaneal bone loss increase with advancing age. J Bone Miner Res 1995; 10:1778–1787.PubMedCrossRefGoogle Scholar
- 21.Ross PD, Knowlton W. Rapid bone loss is associated with increased levels of biochemical markers. J Bone Miner Res 1998; 13:297–302.PubMedCrossRefGoogle Scholar
- 22.Dresner-Pollak R, Parker RA, Poku M, Thompson J, Seibel MJ, Greenspan SL. Biochemical markers of bone turnover reflect femoral bone loss in elderly women. Calcif Tiss Int 1996; 59:328–333.CrossRefGoogle Scholar
- 23.Garnero P, Hausherr E, Chapuy MC, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Min Res 1996; 11:1531–1538.CrossRefGoogle Scholar
- 24.Bollen AM, Kiyak HA, Eyre DR. Longitudinal evaluation of a bone resorption marker in elderly subjects. Osteopor Int 1997; 7:544–549.CrossRefGoogle Scholar
- 25.Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ. Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. J Clin Endocrinol Metab 1996; 81:1129–1133.PubMedCrossRefGoogle Scholar
- 26.LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 1999; 281(16):1505–1511.PubMedCrossRefGoogle Scholar
- 27.Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D on bone density in men and women 65 years of age and older. N Engl J Med 1997; 337:670–676.PubMedCrossRefGoogle Scholar
- 28.Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992; 327:1637–1642.PubMedCrossRefGoogle Scholar
- 29.Recker RR, Hinders S, Davies M, et al. Correcting calcium deficiency prevents spine fractures in elderly women. J Bone Miner Res 1996; 11:1961–1966.PubMedCrossRefGoogle Scholar
- 30.NIH Consensus Conference Optimal Calcium Intake. JAMA 1995; 272:1942–1948.Google Scholar
- 31.Dawson-Hughes B, Harris SS. Calcium intake influcences the association of protein intake with rates of bone loss in elderly men and women. Am J Clin Nutr 2002; 75:773–779.PubMedGoogle Scholar
- 32.Hannan MT, Tucker KL, Dawson-Hughes B, et al. Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. [in process citation] J Bone Miner Res 2000; 15:2504–2512.PubMedCrossRefGoogle Scholar
- 33.Tucker KL, Chen H, Hannan MT, et al. Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr 2002; 76:245–252.PubMedGoogle Scholar
- 34.McKeown NM, Jacques PF, Gundberg CM, et al. Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J Nutr 2002; 132:1329–1334.PubMedGoogle Scholar
- 35.Promislow JH, Goodman-Gruen D., Slymen DJ, Barrett-Connor E. Retinol intake and bone mineral density in the elderly: the Rancho Bernardo Study. J Bone Miner Res 2002; 17(8):1349–1358.PubMedCrossRefGoogle Scholar
- 36.Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003; 348(4):287–294.PubMedCrossRefGoogle Scholar
- 37.Slemenda CW, Longcope C, Zhou L, Hui S, Peacock M, Johnston CC. Sex steroids and bone mass in older men: positive associations with serum estrogens and negative associations with androgens. J Clin Invest 1997; 100:1755–1759.PubMedCrossRefGoogle Scholar
- 38.Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 1997; 12:1833–1843.PubMedCrossRefGoogle Scholar
- 39.Amin S, Xhang Y, Sawin CT, et al. Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study. Ann Intern Med 2000; 133:951–963.PubMedGoogle Scholar
- 40.Khosla S, Atkinson EJ, Dunstan CR, O’Fallon WM. Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men. J Clin Endocrinol Metab 2002; 87(4):1550–1554.PubMedCrossRefGoogle Scholar
- 41.Falahati-Nini A, Riggs BL, Atkinson EJ, O’Fallon WM, Eastell R, Khosla S. Relative contribution of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 2000; 106(12):1553–1560.PubMedCrossRefGoogle Scholar
- 42.Smith MR, Finkelstein JS, McGovern FJ, et al. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab 2002; 87(2):599–603.PubMedCrossRefGoogle Scholar
- 43.Rosen CJ. Serum IGF-I and IGF binding proteins: clinical implications. Clin Chem 1999; 45:1384–1390.PubMedGoogle Scholar
- 44.Langlois JA, Rosen CJ, Visser M, et al. The association between IGF-I and bone mineral density in women and men: the Framingham Heart Study. J Clin Endocrinol Metab 1998; 83:4257–4262.PubMedCrossRefGoogle Scholar
- 45.Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res 2002; 17(6):1044–1050.PubMedCrossRefGoogle Scholar
- 46.Deng HW, Mahaney MC, Williams JT, et al. Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human disease. Genet Epidemiol 2002; 22(1):12–25.PubMedCrossRefGoogle Scholar
- 47.Kiel DP, Myers RH, Cupples LA, et al. The BsmI vitamin D receptor restriction fragment length polymorphism influences the effect of calcium intake on BMD. J Bone Miner Res 1997; 12:1049–1057.PubMedCrossRefGoogle Scholar
- 48.Hayes WC. Biomechanics of cortical and trabecular bone: implications for assessment of fracture risk. In: Mow VC, Hayes WC, eds. Basic Orthopaedic Biomechanics. Raven, New York, 1991, pp. 93–142.Google Scholar
- 49.Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women. N Engl J Med 1995; 332:767–773.PubMedCrossRefGoogle Scholar
- 50.Leibson CL, Tosteson ANA, Gabriel SE, Ransom JE, Melton L. Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc 2002; 50:1644–1650.PubMedCrossRefGoogle Scholar
- 51.Gillespie LD, Gillespie WJ, Robertson MC, Lamb SE, Cumming RG, Rowe BH. Interventions to reduce the incidence of falling in the elderly. The Cochrane Database of Systematic Reviews Issue 4, 2002.Google Scholar
- 52.Riggs BL, O’Fallon WM, Muhs J, O’Connor MK, Kumar R, Melton L. Long term effects of calcium supplementation on serum PTH level, bone turnover and bone loss in elderly women. J Bone Miner Res 1998; 13:168–174.PubMedCrossRefGoogle Scholar
- 53.Storm D, Smith-Porter E, Musgrave KO, et al. Calcium supplementaiton prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial. J Clin Endocrinol Metab 1998; 83:3817–3826.PubMedCrossRefGoogle Scholar
- 54.Shea B, Wells G, Cranney A, et al. Meta analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocr Rev 2002; 23:552–559.PubMedCrossRefGoogle Scholar
- 55.Holick MF. Vitamin D: a millennium perspective. J Cell Biochem 2003; 88:296–307.PubMedCrossRefGoogle Scholar
- 56.Papdimitropoulos E, Wells G, Shea B, et al. Meta analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev 2002; 23:560–569.CrossRefGoogle Scholar
- 57.Geinoz G, Rapin CH, Tizzoli R, et al. Relationship between BMD and dietary intakes in the elderly. Osteopor Int 1993; 3:242–248.CrossRefGoogle Scholar
- 58.Guyatt GH, Cranney A, Griffith L, et al. Summary of meta-analyses of therapies for postmenopausal osteoporosis and the relationship between bone density and fractures. Endocrinol Metab Clin N Am 2002; 31(3):659–679.CrossRefGoogle Scholar