Genomic Responses Following Cerebral Ischemia

  • Christoph Wiessner
  • Konstantin-Alexander Hossmann
Chapter
Part of the Contemporary Neuroscience book series (CNEURO)

Abstract

About 20 yr ago, it was shown that within a few hours after complete cerebral ischemia the enzymes ornithin decarboxylase and S-adenosylmethionin decarboxylase were induced in the cortex, despite an inhibition of the overall rate of protein synthesis (1) that persists for prolonged periods after the ischemic insult (2). About 10 yr later, the postischemic synthesis of the heat shock protein HSP70, and glial fibrillary acidic protein (GFAP) was reported (3–7). Meanwhile, the number of studies concentrating on ischemia-induced synthesis of specific proteins has been exploding. Nevertheless, it can be anticipated that at present the exploration of potentially important genes in vivo is far from complete.

Keywords

Cerebral Ischemia Middle Cerebral Artery Occlusion Amyloid Precursor Protein Focal Cerebral Ischemia Global Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Kleihues, P., Hossmann, K.-A., Pegg, A. E., Kobayashi, K., and Zimmermann, V., Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery, Brain Res., 95 (1975) 61–73.PubMedGoogle Scholar
  2. 2.
    Hossmann, K.-A., Disturbances of protein synthesis and ischemic cell death, Progr. Brain Res., 96 (1993) 161–177.Google Scholar
  3. 3.
    Dienel, G. A. and Cruz, N. F., Induction of brain ornithine decarboxylase during recovery from metabolic, mechanical, thermal, or chemical injury, J. Neurochem., 42 (1984) 1053–1061.PubMedGoogle Scholar
  4. 4.
    Nowak, T. S., Jr., Synthesis of a stress protein following transient ischemia in the gerbil, J. Neurochem., 45 (1985) 1635–1641.PubMedGoogle Scholar
  5. 5.
    Dienel, G. A., Cruz, N. F., and Rosenfeld, S. J., Temporal profiles of proteins responsive to transient ischemia, J. Neurochem., 44 (1985) 600–610.PubMedGoogle Scholar
  6. 6.
    Kiessling, M., Dienel G. A., Jacewicz M., and Pulsinelli W. A., Protein synthesis in postischemic rat brain: a two-dimensional electrophoretic analysis, J. Cereb. Blood Flow Metab., 6 (1986) 642–649.PubMedGoogle Scholar
  7. 7.
    Jacewicz, M., Kiessling, M., and Pulsinelli, W. A., Selective gene expression in focal cerebral ischemia, J. Cereb. Blood Flow Metab., 6 (1986) 263–272.PubMedGoogle Scholar
  8. Lindvall, O., Kokaia, Z., Bengzon, J., Elmer, E., and Kokaia M., Neurotrophins and brain insults, Trends Neurosci.,17 (1994) 490–496.Google Scholar
  9. 9.
    Welch, W. J., Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease, Physiol. Rev., 72 (1992) 1063–1081.PubMedGoogle Scholar
  10. 10.
    Schreiber, S. S. and Baudry, M., Selective neuronal vulnerability in the hippocampus—a role for gene expression, Trends Neurosci., 18 (1995) 446–451.PubMedGoogle Scholar
  11. 11.
    Morgan, J. I. and Curran, T., Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun, Annu. Rev. Neurosci., 14 (1991) 421–451.PubMedGoogle Scholar
  12. 12.
    Eddleston, M. and Mucke, L., Molecular profile of reactive astrocytes-implications for their role in neurologic disease, Neuroscience, 54 (1993) 15–36.PubMedGoogle Scholar
  13. 13.
    Gehrmann, J., Banati, R., Wiessner, C., Hossmann, K.-A., and Kreutzberg, G. W., Reactive microglia in ischemia: an early mediator of tissue damage?, Neurpathol. Appl. Neurobiol., 24 (1995) 277–289.Google Scholar
  14. 14.
    Kochanek, P. M. and Hallenbeck, J. M., Polymorphonuclear leukocytes and monocytes/ macrophages in the pathogenesis of cerebral ischemia and stroke, Stroke, 23 (1992) 1367–1379.PubMedGoogle Scholar
  15. 15.
    Wang, X. K. and Feuerstein, G. Z., Induced expression of adhesion molecules following focal brain ischemia, J. Neurotrauma, 12 (1995) 825–832.PubMedGoogle Scholar
  16. 16.
    Estus, S., Zaks, W. J., Freeman, R. S., Gruda, M., Bravo, R., and Johnson, E. M., Altered gene expression in neurons during programmed cell death-identification of c-jun as necessary for neuronal apoptosis, J. Cell Biol., 127 (1994) 1717–1727.PubMedGoogle Scholar
  17. Colotta, F., Polentarutti, N., Sironi, M., and Mantovani, A., Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines, J. Biol. Chem.,267 (1992) 18,278–18,283.Google Scholar
  18. 18.
    Freeman, R. S., Estus, S., and Johnson, E. M. J., Analysis of cell-cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death, Neuron, 12 (1994) 343–355.PubMedGoogle Scholar
  19. 19.
    Buttyan, R., Zakeri, Z., Lockshin, R., and Wolgemuth, D., Cascade induction of c-fos, c-myc, and heat shock 70K transcripts during regression of the rat ventral prostate gland, Mol. Endocrinol., 2 (1988) 650–657.PubMedGoogle Scholar
  20. 20.
    Buttyan, R., Olsson, C. A., Pintar, J., Chang, C., Bandyk, M., NG, P. Y., and Sawczuk, I. S., Induction of the TRPM-2 gene in cells undergoing programmed cell death, Mol. Cell. Biol., 9 (1989) 3473–3481.PubMedGoogle Scholar
  21. 21.
    Oppenheim, R. W., Cell death during development of the nervous system, Annu. Rev. Neurosci., 14 (1991) 453–501.PubMedGoogle Scholar
  22. 22.
    Siesjö, B. K., Historical overview. Calcium, ischemia, and death of brain cells, Ann. NY Acad. Sci., 522 (1988) 638–661.PubMedGoogle Scholar
  23. 23.
    Siesjö, B. K., Lundgren, J., and Pahlmark, K., The role of free radicals in ishcemic brain damage: a hypothesis. In J. Krieglstein and H. Oberpichler (eds.) Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1990, pp. 319–323.Google Scholar
  24. 24.
    Deckwerth, T. L. and Johnson, E. M. J., Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor, J. Cell. Biol., 123 (1993) 1207–1222.PubMedGoogle Scholar
  25. 25.
    Wiessner, C., Neumann-Haefelin, T., Brink, I., Vogel, P., and Hossmann, K.-A., The genomic response of the rat brain following cerebral ischemia: generalized versus cell and region specific responses. In J. Krieglstein and H. Oberpichler-Schwenk (eds.) Pharamcology of Cerebal Ischemia, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1994, pp. 455–465.Google Scholar
  26. 26.
    Kirino, T., Tamura, A., and Sano, K., Selective vulnerability of the hippocampus to ischemia—reversible and irreversible types of ischemic cell damages, Progr. Brain Res., 63 (1985) 39–55.Google Scholar
  27. 27.
    Horn, M. and Schlote W., Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia, Acta Neuropathol., 85 (1992) 79–87.PubMedGoogle Scholar
  28. 28.
    Duchen, L. W., General Pathology of the Neuron, 4 ed., Edward Arnold, London, 1984.Google Scholar
  29. 29.
    Wiessner, C., Neumann-Haefelin, T., Vogel, P., Back, T., and Hossmann, K.-A., Transient forebrain ischemia induces an immediate-early gene encoding the mitogen-activated protein kinase phosphatase 3CH 134 in the adult rat brain, Neuroscience, 64 (1995) 959–966.PubMedGoogle Scholar
  30. 30.
    Neumann-Haefelin, T., Wiessner, C., Vogel, P., Back, T., and Hossmann, K.-A., Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia, J. Cereb. Blood Flow Metab., 14 (1994) 206–216.PubMedGoogle Scholar
  31. 31.
    Wessel, T. C., Joh, T. H., and Volpe, B. T., In situ hybridization analysis of c-fos and c-jun expression in the rat brain following transient forebrain ischemia, Brain Res., 567 (1991) 231–240.PubMedGoogle Scholar
  32. 32.
    Onodera, H., Kogure, K., Ono, Y., Igarashi, K., Kiyota, Y., and Nagaoka, A., Proto-oncogene c-fos is transiently induced in the rat cerebral cortex after forebrain ischemia, Neurosci. Lett., 98 (1989) 101–104.PubMedGoogle Scholar
  33. 33.
    Kindy, M. S., Carney, J. P., Dempsey, R. J., and Carney, J. M., Ischemic induction of protooncogene expression in gerbil brain, J. Mol. Neurosci., 2 (1991) 217–228.PubMedGoogle Scholar
  34. 34.
    Kiessling, M., Stumm, G., Xie, Y., Herdegen, T., Aguzzi, A., Bravo, R., and Gass, P., Differential expression and translation of immediate early genes in the gerbil hippocampus after transient forebrain ischemia, J. Cereb. Blood Flow Metab., 13 (1993) 914–924.PubMedGoogle Scholar
  35. 35.
    Nowak, T. S., Jr., Osborne, O. C., and Suga, S., Stress protein and proto-oncogene expression as indicators of neuronal pathophysiology after ischemia, Prog. Brain Res., 96 (1993) 195–208.PubMedGoogle Scholar
  36. 36.
    Muller, M., Cleef, M., Rohn, G., Bonnekoh, P., Pajunen, A. E., Bernstein, H. G., and Paschen, W., Ornithine decarboxylase in reversible cerebral ischemia: an immunohistochemical study, Acta Neuropathol., 83 (1991) 39–45.PubMedGoogle Scholar
  37. 37.
    Kawagoe, J.-I., Abe, K., Aoki, M., and Kogure, K., Induction of HSP90alpha heat shock mRNA after transient global ischemia in gerbil hippocampus, Brain Res., 621 (1993) 121–125.PubMedGoogle Scholar
  38. 38.
    Paschen, W., Uto, A., Djuricic, B., and Schmitt, J., Hemeoxygenase expression after reversible ischemia of rat brain, Neurosci. Lett., 180 (1994) 5–8.PubMedGoogle Scholar
  39. 39.
    Endoh, M., Pulsinelli, W. A., and Wagner, J. A., Transient global ischemia induces dynamic changes in the expression of bFGF and the FGF receptor, Mol. Brain Res., 22 (1994) 76–88.PubMedGoogle Scholar
  40. 40.
    Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M. L., Siesjo, B. K., and Persson, H., Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma, Proc. Natl. Acad. Sci. USA, 89 (1992) 648–652.PubMedGoogle Scholar
  41. 41.
    Kitagawa, K., Matsumoto, M., Tagaya, M., Hata, R., Ueda, H., Niinobe, M., Handa, N., Fukunaga, R., Kimura, K., Mikoshiba, K., and Kamada, T., `Ischemic tolerance’ phenomenon found in the brain, Brain Res., 528 (1990) 21–24.PubMedGoogle Scholar
  42. 42.
    Kirino, T., Tsujita, Y., and Tamura, A., Induced tolerance to ischemia in gerbil hippocampal neurons, J. Cereb. Blood Flow Metab., 11 (1991) 299–307.PubMedGoogle Scholar
  43. 43.
    Nowak, T. S., Jr. and Jacewicz, M., The heat shock/stress response in focal cerebral ischemia, Brain Pathol., 4 (1994) 67–76.PubMedGoogle Scholar
  44. 44.
    Nishi, S., Taki, W., Uemura, Y., Higashi, T., Kikuchi, H., Kudoh, H., Satoh, M., and Nagata, K., Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model, Brain Res., 615 (1993) 281–288.PubMedGoogle Scholar
  45. 45.
    Sommer, C., Gass, P., and Kiessling, M., Selective c-jun expression in CA1 neurons of the gerbil hippocampus during and after acquisition of an ischemia-tolerant state, Brain Pathol., 5 (1995) 135–144.PubMedGoogle Scholar
  46. 46.
    Abe, H., Xu, Z. K., and Nowak, T. S. J., Threshold depolarization intervals for ischemic tolerance versus expression of HSP72 and other ischemia-induced mRNAs, J. Cereb. Blood Flow Metab., 15 (Suppl. 1) (1995) S67.Google Scholar
  47. 47.
    Jorgensen, M. B., Deckert, J., Wright, D. C., and Gehlert, D. R., Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study, Brain Res., 484 (1989) 393–398.PubMedGoogle Scholar
  48. 48.
    Dragunow, M., Yooung, D., Hughes, P., MacGibbon, G., Lawlor, P., Singleton, K., Sirimanne, E., Beilharz, E., and Gluckman, P., Is c-jun involved in nerve cell death follwoing status epilepticus and hypoxic-ischemia brain injury, Mol. Brain Res., 18 (1993) 347–352.PubMedGoogle Scholar
  49. 49.
    Nowak, T. D. J., Prolonged expression of hsp70 mRNA as an early indicator of neuronal vulnerability following ischemia. In J. Krieglstein and H. Oberpichler (eds.) Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1990, pp. 117–121.Google Scholar
  50. 50.
    Tomioka, C., Nishioka, K., and Kogure, K., A comparison of induced heat-shock protein in neurons destined to survive and those destined to die after transient ischemia in rats, Brain Res., 612 (1993) 216–220.PubMedGoogle Scholar
  51. 51.
    Milarski, K. and Morimoto, R. I., Expression of human HSP70 during the synthestic phase of teh cell cycle, Proc. Natl. Acad. Sci. USA, 83 (1986) 9517–9521.PubMedGoogle Scholar
  52. 52.
    Colombel, M., Olsson, C. A., Ng, P. Y., and Buttyan, R., Hormone-regulated apoptosis results from reentry of differentiated prostate cells into a defective cell cycle, Cancer Res., 52 (1992) 4313–4319.PubMedGoogle Scholar
  53. 53.
    Saito, N., Kawai, K., and Nowak, T. S., Jr., Reexpression of developmentally regulated MAP2c mRNA after ischemia: colocalization with hsp72 mRNA in vulnerable neurons, J. Cereb. Blood Flow Metab., 15 (1995) 205–215.PubMedGoogle Scholar
  54. 54.
    Stubberöd, P., Tomasevic, G., Kamme, F., and Wieloch, T., Expression of the tumor supressor p53 and WAF 1 in the postischemic rat hippocampus, Abstr. Soc. Neurosci., 20 (1994) 616.Google Scholar
  55. 55.
    Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H., Thymocyte apoptosis induced by p53-dependent and independent pathways, Nature, 362 (1993) 849–852.PubMedGoogle Scholar
  56. 56.
    Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T., p53 is required for radiation-induced apoptosis in mouse thymocytes, Nature, 362 (1993) 847–849.PubMedGoogle Scholar
  57. 57.
    Nitatori, T., Sato, N., Waguri, S., Karasawa, Y., Araki, H., Shibanai, K., Kominami, E., and Uchiyama, Y., Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis, J. Neurosci., 15 (1995) 1001–1011.PubMedGoogle Scholar
  58. 58.
    Glaumann, H., Ericsson, L. E., and Marzella, L., Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles, Int. Rev. Cytol., 73 (1981) 149–182.PubMedGoogle Scholar
  59. 59.
    Smeyne, R. J., Vendrell, M., Hayward, M., Baker, S. J., Miao, G. G., Schilling, K., Robertson, L. M., Curran, T., and Morgan, J. I., Continous c-fos expression precedes programmed cell death in vivo, Nature, 363 (1993) 166–169.PubMedGoogle Scholar
  60. 60.
    Ikeda, J., Nakajima, T., Osborne, O. C., Mies, G., and Nowak, T. S., Jr., Coexpression of c-fos and hsp70 mRNAs in gerbil brain after ischemia: induction threshold, distribution and time course evaluated by in situ hybridization, Mol. Brain Res., 26 (1994) 249–258.PubMedGoogle Scholar
  61. 61.
    Vass, K., Welch, W. J., Nowak, T. S., Jr., Localization of 70 kDa stress protein induction in gerbil brain after ischemia, Acta Neuropathol. (Berlin), 77 (1989) 128–135.Google Scholar
  62. 62.
    Wiessner, C., Brink, I., Lorenz, P., Neumann-Haefelin, T., Vogel, P., and Yamashita, K., Cyclin D1 messenger RNA is induced in microglia rather than neurons following transient forebrain ischemia, Neuroscience, 72 (1996) 947–958.PubMedGoogle Scholar
  63. 63.
    Wiessner, C., Back, T., Bonnekoh, P., Kohn, K., Gehrmann, J., and Hossmann, K.-A., Sulfated glycoprotein-2 mRNA in the rat brain following transient forebrain ischemia, Mol. Brain Res., 20 (1993) 345–352.PubMedGoogle Scholar
  64. 64.
    Krajewski, S., Mai, J. K., Krajewska, M., Sikorska, M., Mossakowski, M. J., and Redd, J. C., Up-regulation of bax protein-levels in neurons following cerebral ischemia, J. Neurosci., 15 (1995) 6364–6376.PubMedGoogle Scholar
  65. 65.
    Shigeno, T., Yamasaki, Y., Kato, G., Kusaka, K., Mima, T., Takakura, K., Graham, D. I., and Furukawa, S., Reduction of delayed neuronal death by inhibition of protein synthesis, Neurosci. Lett., 120 (1990) 117–119.PubMedGoogle Scholar
  66. 66.
    Goto, K., Ishige, A., Sekiguchi, K., Iizuka, S., Sugimoto, A., Yuzurihara, M., Aburada, M., Hosoya, E., and Kogure, K., Effects of cycloheximide on delayed neuronal death in rat hippocampus, Brain Res., 534 (1990) 299–302.PubMedGoogle Scholar
  67. 67.
    Tortosa, A., Rivera, R., and Ferrer, I., Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia, J. Neurol. Sci., 121 (1994) 10–17.PubMedGoogle Scholar
  68. 68.
    Kiessling, M., Xie, Y., Ullrich, B., and Thilmann, R., Are the neuroprotective effects of the protein synthesis inhibitor cycloheximide due to prevention of apoptosis, J. Cereb. Blood Flow Metab., 11 (Suppl. 2) (1991) S357.Google Scholar
  69. 69.
    Minamisawa, H., Nordström, C. H., Smith, M. L., and Siesjö, B. K., The influence of mild body and brain hypothermia on ischemic brain damage, J. Cereb. Blood Flow Metab., 10 (1990) 817–822.Google Scholar
  70. 70.
    Busto, R., Dietrich, W. D., Globus, M. Y., and Ginsberg, M. D., Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury, Neurosci. Lett., 101 (1989) 299–304.PubMedGoogle Scholar
  71. 71.
    Ferrer, I., Tortosa, A., Macaya, A., Sierra, A., Moreno, D., Munell, F., Blanco, R., and Squier, W., Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil, Brain Pathol., 4 (1994) 115–122.PubMedGoogle Scholar
  72. 72.
    Heron, A., Pollard, H., Dessi, F., Moreau, J., Lasbennes, F., Ben-Ari, Y., and CharriautMarlangue, C. R., Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in rat brain, J. Neurochem., 61 (1993) 1973–1976.PubMedGoogle Scholar
  73. 73.
    MacManus, J. P., Hill, I. E., Preston, E., Rasquinha, I., Walker, T., and Buchan, A. M., Differences in DNA fragmetnation following transient cerebral or decapitation ischemia in rats, J. Cereb. Blood Flow Metab., 15 (1995) 728–737.PubMedGoogle Scholar
  74. 74.
    Beck, T., Lindholm, D., Castren, E., and Wree, A., Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus, J. Cereb. Blood Flow Metab., 14 (1994) 689–692.PubMedGoogle Scholar
  75. Ghosh, A., Carnahan, J., and Greenberg, M. E., Requirement for BDNF in activity-dependent survival of cortical neurons, Science,263 (1994) 1618–1623.Google Scholar
  76. 76.
    Kleihues, P. and Hossmann K.-A., Protein synthesis in the cat brain after prolonged cerebral ischemia, Brain Res., 35 (1971) 409–418.PubMedGoogle Scholar
  77. 77.
    Dienel, G. A., Pulsinelli, W. A., and Duffy, T. E., Regional protein synthesis in rat brain following acute hemispheric ischemia, J. Neurochem., 35 (1980) 1216–1226.PubMedGoogle Scholar
  78. 78.
    Cooper, H. K., Zalwska, T., Kawakami, S., Hossmann, K.-A., and Kleinhues, P., The effect of ischemia and recirculation on protein synthesis in the rat brain, J. Neurochem., 28 (1977) 929–934.PubMedGoogle Scholar
  79. 79.
    Lindquist, S., The heat-shock response, Ann. Rev. Biochem., 55 (1986) 1151–1191.PubMedGoogle Scholar
  80. 80.
    Vogel, P., Wiessner, C., Dux, E., Uto, A., and Hossmann, K.-A., Heat shock in neuronal cell cultures: a simple model for studying mechansims of ischemic injury?, Eur. J. Neurosci., (Suppl. 7) (1994) 16. 01.Google Scholar
  81. 81.
    Hossmann, K.-A., Widmann, R., Wiessner, C., Duc, E., Djuricic, B., and Röhn, G., Protein synthesis after global ischemia and selective vulnerability. In J. Krieglstein and H. Oberpichler-Schwenk (eds.) Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1992, pp. 289–299.Google Scholar
  82. 82.
    Bodsch, W., Takahashi, K., Barbier, A., Grosse, Ophoff, B., and Hossmann, K.-A., Cerebral protein synthesis and ischemia, Progr. Brain Res., 63 (1985) 197–210.Google Scholar
  83. 83.
    Thilmann, R., Xie, Y., Kleihues, P., and Kiessling, M., Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus, Acta Neuropathol., 71 (1986) 88–93.PubMedGoogle Scholar
  84. 84.
    Widmann, R., Kuroiwa, T., Bonnekoh, P., and Hossmann, K.-A., [14C]leucine incorporation into brain proteins in gerbils after transient ischemia: relationship to selective vulnerability of hippocampus, J. Neurochem., 56 (1991) 789–796.PubMedGoogle Scholar
  85. 85.
    Oliver, C. N., Starke-Reed, P. E., Stadtman, E. R., Lin, G. J., Carney, J. M., and Floyd, R. A., Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemial reperfusion-induced injury to gerbil brain, Proc. Natl. Acad. Sci. USA, 87 (1990) 5144–5147.PubMedGoogle Scholar
  86. 86.
    Seubert, P., Lee, K., and Lynch, G., Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus, Brain Res., 492 (1989) 366–370.PubMedGoogle Scholar
  87. 87.
    Siman, R., Noszek, J. C., and Kegerise, C., Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage, J. Neurosci., 9 (1989) 1579–1590.PubMedGoogle Scholar
  88. 88.
    Wiessner, C., Vogel, P., Neumann-Haefelin, T., and Hossmann, K.-A., Molecular correlates of delayed neuronal death following transient forebrain ischemia, Acta Neurochir., 66 (Suppl.) (1996) 1–7.Google Scholar
  89. 89.
    Uemura, Y., Konwall, N. W., and Beal, M. F., Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus, Brain Res., 542 (1991) 343–447.PubMedGoogle Scholar
  90. 90.
    Nowak, T. S., Jr., Ikeda, J., and Nakajima, T., 70-kDa heat shock protein and c-fos gene expression after transient ischemia, Stroke,21 (1990) III107–111.Google Scholar
  91. 91.
    Schmidt- Kastner, R. and Szymas, J., Immunohistochemistry of glial fibrillary acidic protein, vimentin and S-100 protein for study of astrocytes in hippocampus of rat, J. Chem. Neuroanatomy, 3 (1990) 179–192.Google Scholar
  92. 92.
    Gehrmann, J., Bonnekoh, P., Miyazawa, T., Hossmann, K.-A., and Kreutzberg, G. W., Immunocytochemical study of an early microglial activation in ischemia, J. Cereb. Blood Flow Metab., 12 (1992) 257–269.PubMedGoogle Scholar
  93. 93.
    Wiessner, C., Gehrmann, J., Lindholm, D., Topper, R., Kreutzberg, G. W., and Hossmann, K.-A., Expression of transforming growth factor-beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia, Acta Neuropathol., 86 (1993) 439–446.PubMedGoogle Scholar
  94. 94.
    Schmidt-Kastner, R., Szymas, J., and Hossmann, K -A, Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia, Neuroscience, 38 (1990) 527–540.PubMedGoogle Scholar
  95. 95.
    Petito, C. K. and Halaby, I. A., Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic protein, Int. J. Dey. Neurosci., 11 (1993) 239–247.Google Scholar
  96. 96.
    Petito, C. K., Morgello, S., Felix, J. C., and Lesser, M. L., The two patterns of reactive astrocytosis in postischemic rat brain, J. Cereb. Blood Flow Metab., 10 (1990) 850–859.PubMedGoogle Scholar
  97. 97.
    Eng, L. F. and Ghirnikar, R. S., GFAP and astrogliosis, Brain Pathol., 4 (1994) 229–237.PubMedGoogle Scholar
  98. 98.
    Petito, C. K. and Babiak, T., Early proliferative changes in astrocytes in postischemic non-infarcted rat brain, Ann. Neurol., 11 (1982) 510–518.PubMedGoogle Scholar
  99. 99.
    Kindy, M. S., Bhat, A. N., and Bhat, N. R., Transient ischemia stimulates glial fibrillary acid protein and vimentin gene expression in the gerbil neocortex, striatum and hippocampus, Mol. Brain Res., 13 (1992) 199–206.PubMedGoogle Scholar
  100. 100.
    May, P. C. and Finch C. E., Sulfated glycoprotein 2: new realtionships of this multifunctional protein to neurodegeneration, Trends Neurol. Sci., 15 (1992) 391–396.Google Scholar
  101. 101.
    Dragunow, M., Preston, K., Dodd J., Young, D., Lawlor, P., and Christie, D., Clusterin accumulates in dying neurons following status epilepticus, Mol. Brain Res., 32 (1995) 279–290.PubMedGoogle Scholar
  102. 102.
    Takami, K., Iwane, M., Kiyota, Y., Miyamoto, M., Tsukuda, R., and Shiosaka, S., Increase of basic fibroblast growth factor immunoreactivity and its mRNA level in rat brain following transient forebrain ischemia, Exp. Brain Res., 90 (1992) 1–10.PubMedGoogle Scholar
  103. 103.
    Takami, K., Kiyota, Y., Iwane, M., Miyamoto, M., Tsukuda, R., Igarashi, K., Shino, A., Wanaka, A., Shiosaka, S., and Tohyama, M., Upregulation of fibroblast growth factor-receptor messenger RNA expression in rat brain following transient forebrain ischemia, Exp. Brain Res., 97 (1993) 185–194.PubMedGoogle Scholar
  104. 104.
    Gluckmann, P., Klempt, N., and Guan, J., A role for IGF-1 in the rescue of neurons following hypoxic-ischemic injury, Biochem. Biophys. Res. Commun., 31 (1992) 593–599.Google Scholar
  105. 105.
    Banati, R., Gehrmann, J., Wiessner, C., Hossmann, K.-A., and Kreutzberg, G. W., Glial expression of the ß-amyloid precursor protein (APP) in global ischemia, J. Cereb. Blood Flow Metab., 15 (1995) 647–654.PubMedGoogle Scholar
  106. 106.
    Unsicker, K., Prehn, J. H. M., Backhaub, C., Krieglstein K., Otto D., and Krieglstein J., Growth factors and their implications for the injured brain: regulation and neuroprotective effects of FGFs and TGF-13s in ischemic and other lesion paradigms. In J. Krieglstein and H. Oberpichler-Schwenk (eds.) Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1992, pp. 229–238.Google Scholar
  107. 107.
    Bergstedt, K. and Wieloch T., Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat. Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1, J. Cereb. Blood Flow Metab., 13 (1993) 895–898.PubMedGoogle Scholar
  108. 108.
    Endoh, M., Maiese, K., and Wagner, J. A., Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia, Brain Res., 651 (1994) 92–100.PubMedGoogle Scholar
  109. 109.
    Banati, R. B., Gehrmann, J., Schubert, P., and Kreutzberg, G. W., Cytotoxicity of microglia, Glia, 7 (1993) 111–118.PubMedGoogle Scholar
  110. 110.
    Tsirka, S. E., Gualandris, A., Amaral, D. G., and Strickland, S., Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen factor, Nature, 377 (1995) 340–344.PubMedGoogle Scholar
  111. 111.
    Morioka, T., Kalehua, A. N., and Streit, W. J., Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia, Acta Neuropathol., 83 (1992) 149–157.PubMedGoogle Scholar
  112. 112.
    Morioka, T., Kalehua, A. N., and Streit, W. J., The microglial reaction in the rat dorsal hippocampus following trasnient forebrain ischemia, J. Cereb. Blood Flow Metab., 11 (1991) 966–973.PubMedGoogle Scholar
  113. 113.
    Gehrmann, J., Bonnekoh, P., Miyazawa, T., Oschlies, U., Dux, E., Hossmann, K.-A., and Kreutzberg, G. W., The microglial reaction in the rat hippocmapus following global ischemia: immuno-electron microscopy, Acta Neuropathol., 84 (1992) 588–595.PubMedGoogle Scholar
  114. 114.
    Jorgensen, M. B., Finsen, B. R., Jensen, M. B., Castellano, B., Diemer, N. H., and Zimmer, J., Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus, Exp. Neurol., 120 (1993) 70–88.PubMedGoogle Scholar
  115. 115.
    Finsen, B. R., Jorgensen, M. B., Diemer, N. H., and Zimmer, J., Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus, Glia, 7 (1993) 41–49.PubMedGoogle Scholar
  116. 116.
    Sherr, C. J., G1 phase progression: cycling on cue, Cell, 79 (1994) 551–555.PubMedGoogle Scholar
  117. 117.
    Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J., and Weinberg, R. A., Cyclin D1 provides a link between development and oncogenesis in the retina and breast, Cell, 82 (1995) 621–630.PubMedGoogle Scholar
  118. 118.
    Lau, L. F. and Nathans, D., Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells, EMBO J., 4 (1985) 3145–3151.PubMedGoogle Scholar
  119. 119.
    Lehrmann, E., Kiefer, R., Finsen, B., Diemer, N. H., Zimmer, J., and Hartung, H. P., Cytokines in cerebral ischemia: expression of transforming growth factor beta-1 (TGF-beta 1) mRNA in the postischemic adult rat hippocampus, Exp. Neurol., 131 (1995) 114–123.PubMedGoogle Scholar
  120. 120.
    Klempt, N. D., Sirimanne, E., Gunn, A. J., Klempt, M., Singh, K., Williams, C., and Gluckman, P. D., Hypoxia-ischemia induces transforming growth factor beta 1 mRNA in the infant rat brain, Mol. Brain Res., 13 (1992) 93–101.PubMedGoogle Scholar
  121. 121.
    Morgan, T. E., Laping N. J., Rozovsky I., Oda T., Hogan T. H., Finch C. E., and Pasinetti G. M., Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions, JNeuroimmunol., 58 (1995) 101–110.Google Scholar
  122. 122.
    Barnard, J. A., Bascom, C. C., Lyons, M. M., Sipes, N. J., and Moses, H. L., Transforming growth factor ß in control of epidermal proliferation, Am. J. Med. Sci., 296 (1988) 159–163.PubMedGoogle Scholar
  123. 123.
    Bainton, D. F., Miller, L. J., Kishimoto, T. K., and Springer, T. A., Leucocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophiles, J. Exp. Med., 166 (1987) 1641–1653.PubMedGoogle Scholar
  124. 124.
    O’Shea, J. J., Brown, E. J., Seligmann, B. E., Metcalf, J. A., Frank, M. M., and Gallin, J. I., Evidence for distinct intracellular pools of receptors for Cab and C3bi in human neutrophils, J. Immunol., 134 (1985) 2580–2586.PubMedGoogle Scholar
  125. 125.
    Beyreuther, K. and Masters, C. L., Amyloid precursor protein (APP) and ßA4 amyloid in the etiology of Alzheimer’s disease: precursor-product relationships in the derangement of neuronal function, Brain Pathol., 1 (1991) 241–251.Google Scholar
  126. 126.
    Abe, K., Tanzi, R. E., St. George-Hyslop, P. H., and Kogure, K., Induction of amyloid precursor protein (APP) gene after middle artery occlusion of rats, J.Cereb. Blood Flow Metab., 11 (Suppl. 2) (1991) S351.Google Scholar
  127. 127.
    Kalaria, R. N., Bhatti, S. U., Palatinsky, E. A., Pennington, D. H., Shelton, E. R., Chan, H. W., Perry, G., and Lust, W. D., Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain, Neuroreport, 4 (1993) 211–214.PubMedGoogle Scholar
  128. 128.
    Stephenson, D. T., Rash, K., and Clemens, J. A., Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat, Brain Res., 593 (1992) 128–135.PubMedGoogle Scholar
  129. 129.
    Wakita, H., Tomimoto, H., Akiguchi, I., Ohnishi, K., Nakamura, S., and Kimura, J., Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia, Neurosci. Lett., 146 (1992) 135–138.PubMedGoogle Scholar
  130. 130.
    Abe, K., Tanzi, R. E., and Kogure, K., Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex, Neurosci. Lett., 125 (1991) 172–174.PubMedGoogle Scholar
  131. 131.
    Xie, Y. X., Herget T., Hallmayer J., Starzinski-Powitz A., and Hossmann K.-A., Determination of RNA content in postischemic gerbil brain by in situ hybridization, Metab. Brain Dis., 4 (1989) 239–251.PubMedGoogle Scholar
  132. 132.
    Hall, E. D., Ostveen, J. A., Dunn, E., and Carter, D. B., Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia, Exp. Neurol., 135 (1995) 17–27.Google Scholar
  133. 133.
    Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families, Science, 261 (1993) 921–923.PubMedGoogle Scholar
  134. 134.
    Hossmann, K.-A., Animal models of cerebral ischemia. 1. Review of literature, Cereborvasc. Dis., 1 (Suppl. 1) (1991) 2–15.Google Scholar
  135. 135.
    Dereski, M. O., Chopp, M., Knight, R. A., Rodolosi, L. C., and Garcia, J. H., The heteroenous temporal evolution of focal ischemic neuronal damage in the rat, Acta Neuropathol., 85 (1993) 327–333.PubMedGoogle Scholar
  136. 136.
    Bartus, R. T., Dean, R. L., Cavanaugh, K., Eveleth, D., Carriero, D. L., and Lynch, G., Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain, J. Cereb. Blood Flow Metab., 15 (1995) 969–979.PubMedGoogle Scholar
  137. 137.
    Gonzalez, M. F., Shiraishi, K., Hisanaga, K., Sagar, S. M., Mandabach, M., and Sharp, F. R., Heat shock proteins as markers of neuronal injury, Mol. Brain Res., 6 (1989) 93–100.PubMedGoogle Scholar
  138. 138.
    Welsh, F. A., Moyer, D. J., and Harris, V. A., Regional expression of heat shock protein-70 mRNA and c-fos mRNA following focal ischemia in rat brain, J. Cereb. Blood Flow Metab., 12 (1992) 204–212.PubMedGoogle Scholar
  139. 139.
    Abe, K., Kawagoe, J., Araki, T., Aoki, M., and Kogure, K., Differential expression of heat shock protein 70 gene between the cortex and caudate after transient focal cerebral ischaemia in rats, Neurol. Res., 14 (1992) 381–385.PubMedGoogle Scholar
  140. 140.
    Li, Y., Chopp, M., Zhang, Z. G., Zhang, R. L., and Garcia, J. H., Neuronal survival is associated with 72 kDa heat shock protein expression after transient middle artery oclusion, J. Neurol. Sci., 120 (1993) 187–194.PubMedGoogle Scholar
  141. 141.
    Kokaia, Z., Zhao, Q., Kokaia, M., Elmer, E., Metsis, M., Smith, M. L., Siesjo, B. K., and Lindvall, O., Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage, Exp. Neurol., 136 (1995) 73–88.PubMedGoogle Scholar
  142. 142.
    Hsu, C. Y., An, G., Liu, J. S., Xue, J. J., He, Y. Y., and Lin, T. N., Expression of immediate early gene and growth factor mRNAs in a focal cerebral ischemia model in the rat, Stroke,24 (1993)178–188.Google Scholar
  143. 143.
    An, G., Lin, T. N., Liu, J. S., Xue, J. J., He, Y. Y., and Hsu, C. Y., Expression of c-fos and c-jun family genes after focal cerebral ischemia, Ann. Neurol., 33 (1993) 457–464.PubMedGoogle Scholar
  144. 144.
    An, G., Lin, T. N., Liu, J. S., and Hsu, C. Y., Induction of Krox-20 expression after focal cerebral ischemia, Biochem. Biophys. Res. Commun., 188 (1992) 1104–1110.PubMedGoogle Scholar
  145. 145.
    Abe, K., Kawagoe, J., Sato, S., Sahara, M., and Kogure, K., Induction of the `zinc finger’ gene after transient focal ischemia in rat cerebral cortex, Neurosci. Lett., 123 (1991) 248–250.PubMedGoogle Scholar
  146. 146.
    Li, Y., Chopp, M., Zhang, Z. G., Zalog, C., Niewenhuis, L., and Gautam, S., p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats, Stroke, 25 (1994) 849–855.PubMedGoogle Scholar
  147. 147.
    Crumrine, R. C., Thomas, A. L., and Morgan, P. F., Attenuation of p53 expression protects against focal ischemic damage in transgenic mice, J. Cereb. Blood Flow Metab., 14 (1994) 887–891.PubMedGoogle Scholar
  148. 148.
    Chen, J., Graham, S. H., Chan, P. H., Lan, J. Q., Zhou, R. L., and Simon, R. P., Bc1–2 is expressed in neurons that survive focal ischemia in the rat, Neuroreport, 6 (1995) 394–398.PubMedGoogle Scholar
  149. 149.
    Martinou, J. C., Dubois-Dauphin, M., Staple, J. K., Rodriguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., Pietra, C., and Huarte, J., Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia, Neuron, 13 (1994) 1017–1030.PubMedGoogle Scholar
  150. 150.
    Hockenberry, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L., and Korsmeyer, S. J., Bc1–2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75 (1993) 241–251.Google Scholar
  151. 151.
    Wang, X., Yue, T.-L., Barone, F. C., White, R. F., Gagnon, R. C., and Feuerstein, G. Z., Concomitant cortical expression of TNFalpha and IL-1[3 mRNAs follows early response gene expression in transient fical ischemia, Mol. Chem. Neuropathol., 23 (1994) 103–114.PubMedGoogle Scholar
  152. 152.
    Merril, J. E. and Miller Jonakait, G., Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease, FASEB J., 9 (1995) 611–618.Google Scholar
  153. 153.
    Wang, X., Siren, A.-L., Liu, Y., Yue T.-L., Barone, F. C., and Feuerstein, G. Z., Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvasvular endothelial cells in rat ischemic cortex, Mol. Brain Res., 26 (1994) 61–68.PubMedGoogle Scholar
  154. 154.
    Okada, Y., Copeland, B. R., Mori E., Tung, M. M., Thomas, W. S., and del Zoppo, G. J., P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion, Stroke, 25 (1994) 202–211.PubMedGoogle Scholar
  155. 155.
    Zhang, R. L., Chopp, M., Jiang, N., Tang, W. X., Prostak, J., Manning, A. M., and Anderson, D. C., Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat, Stroke, 26 (1995) 1438–1443.PubMedGoogle Scholar
  156. 156.
    Matsuo, Y., Onodera, H., Shiga, Y., Shozuhara, H., Ninomya, M., Kihara, T., Tamatami, T., Miyasaka M., and Kogure K., Role of adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat, Brain Res., 656 (1994) 344–352.PubMedGoogle Scholar
  157. 157.
    Chen, H., Chopp, M., Zhang, R. L., Bodzin, G., Chen, Q., Rusche, J. R., and Todd, R. F., III, Anti-CD1lb monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia, Ann. Neurol., 35 (1994) 458–463.PubMedGoogle Scholar
  158. 158.
    Betz, A. L., Yang, G. Y., and Davidson, B. L., Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain, J. Cereb. Blood Flow Metab., 15 (1995) 547–551.PubMedGoogle Scholar
  159. 159.
    Wang, X., Yue, T. L., Barone, F. C., and Feuerstein, G. Z., Mònocyte chemoattractant protein-1 messenger RNA expression in rat ischemic cortex, Stroke, 26 (1995) 661–665.PubMedGoogle Scholar
  160. 160.
    Clark, R. K., Lee, E. V., Fish, C. J., White, R. F., Price, W. J., Jonak, Z. L., Feuerstein, G. Z., and Barone, F. C., Development of tissue damage, inflammation and resolution following stroke: an immunohistochemical and quantitative study, Brain Res. Bull., 31 (1993) 565–572.PubMedGoogle Scholar
  161. 161.
    Kinouchi, H., Sharp, F. R., Chan, P. H., Koistinaho, J., Sagar, S. M., and Yoshimoto, T., Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion, J. Cereb. Blood Flow Metab., 14 (1994) 808–817.PubMedGoogle Scholar
  162. 162.
    Kinouchi, H., Sharp, F. R., Koistinaho, J., Hicks, K., Kamii, H., and Chan, P. H., Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the `penumbra’ following focal cerebral ischemia in the rat, Brain Res., 619 (1993) 334–338.PubMedGoogle Scholar
  163. 163.
    Sharp, F. R., Lowenstein, D., Simon, R., and Hisanaga, K., Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction, J. Cereb. Blood Flow Metab., 11 (1991) 621–627.PubMedGoogle Scholar
  164. 164.
    Iizuka, H., Sakatani, K., and Young, W., Selective cortical neuronal damage after middle cerebral artery occlusion in rats, Stroke, 20 (1989) 1516–1523.PubMedGoogle Scholar
  165. 165.
    Higashi, T., Takechi, H., Uemura, Y., Kikuchi, H., Nagata, K., Differential induction of mRNA species encoding several cases of stress proteins following focal cerebral ischemia in rats, Brain Res., 650 (1994) 239–248.PubMedGoogle Scholar
  166. 166.
    Wang, S., Longo, F. M., Chen, J., Butman, M., Graham, S., Haglid, K. G., and Sharp, F. R., Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia, Neurochem. Int., 23 (1993) 575–582.PubMedGoogle Scholar
  167. 167.
    Uemura, Y., Kowall, N. W., and Moskowitz, M. A., Focal ischemia in rats causes time-dependent expression of c-fos protein immunoreactivity in widespread regions of ipsilateral cortex, Brain Res., 552 (1991) 99–105.PubMedGoogle Scholar
  168. 168.
    Gass, P., Spranger, M., Herdegen, T., Bravo, R., Kock, P., Hacke, W., and Kiessling, M., Induction of FOS and JUN proteins after focal ischemia in the rat: differential effect of the N-methyl-D-aspartate receptor antagonist MK-801, Acta Neuropathol., 84 (1992) 545–553.PubMedGoogle Scholar
  169. 169.
    Zhang, Z. G., Chopp, M., Gautam, S., Zaloga, C., Zhang, R. L., Schmidt, H. H., Pollock, J. S., and Forstermann, U., Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat, Brain Res., 654 (1994) 85–95.PubMedGoogle Scholar
  170. 170.
    Back, T., Kohno, K., and Hossmann, K.-A., Cortical negative DC deflections following middle cerebral artery occlusion and KCL-induced spreading depression: effect on blood flow, tissue oxigenation and electroencephalogram, J. Cereb. Blood Flow Metab., 14 (1993) 12–19.Google Scholar
  171. 171.
    Mies, G., Iijima, T., and Hossmann, K.-A., Correlation between periinfarct shifts and ischaemic neuronal damge in rat, Neuroreport, 4 (1993) 709–711.PubMedGoogle Scholar
  172. 172.
    Liu, T., McDonnell, P. C., Young, P. R., White, R. F., Siren, A. L., Hallenbeck, J. M., Barone, F. C., and Feurestein, G. Z., Interleukin-1 beta mRNA expression in ischemic rat cortex, Stroke, 24 (1993) 1746–1750.PubMedGoogle Scholar
  173. 173.
    Liu, T., Clark, R. K., McDonnell, P. C., Young, P. R., White, R. F., Barone, F. C., and Feuerstein, G. Z., Tumor necrosis factor-alpha expression in ischemic neurons, Stroke, 25 (1994) 1481–1488.PubMedGoogle Scholar
  174. 174.
    Wang, X., Yue, T. L., Young, P. R., Barone, F. C., and Feuerstein, G. Z., Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex, J. Cereb. Blood Flow Metab., 15 (1995) 166–171.PubMedGoogle Scholar
  175. 175.
    Buttini, M., Sauter, A., and Boddeke, H. W. G. M., Induction of interleukin-1ß mRNA after focal cerebral ischemia in the rat, Mol. Brain Res., 23 (1994) 126–134.PubMedGoogle Scholar
  176. 176.
    Wang, X., Yue, T.-L., White, R. F., Barone, F. C., and Feuerstein, G. Z., Transforming growth factor-pl exhibits delayed gene expression folowing focal cerebral ischemia, Brain Res. Bull., 36 (1995) 607–609.PubMedGoogle Scholar
  177. 177.
    Kim, J. S., Gautam, S. C., Chopp, M., Zaloga, C., Jones, M. L., Ward, P. A., and Welch, K. M., Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat, J. Neuroimmunol., 56 (1995) 127–134.PubMedGoogle Scholar
  178. 178.
    Wang, X., Yue, T. L., Barone, F. C., and Feuerstein, G. Z., Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex, Stroke, 26 (1995) 1665–1668.PubMedGoogle Scholar
  179. 179.
    Liu, T., Young, P. R., McDonnell, P. C., White, R. F., Barone, F. C., and Feuerstein, G. Z., Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia, Neurosci. Lett., 164 (1993) 125–128.PubMedGoogle Scholar
  180. 180.
    Iihara, K., Sasahara, M., Hashimoto, N., Uemura, Y., Kikuchi, H., and Hazama, F., Ischemia induces the expression of the platelet-derived growth factor-B chain in neurons and brain macrophages in vivo, J. Cereb. Blood Flow Metab., 14 (1994) 818–824.PubMedGoogle Scholar
  181. 181.
    Iadecola, C., Zhang, F., Xu, S., Casey, R., and Ross, M. E., Inducible nitric oxide synthase gene expression in brain following cerebral ischemia, J. Cereb. Blood Flow Metab., 15 (1995) 378–384.PubMedGoogle Scholar
  182. 182.
    Li, Y., Chopp, M., Jiang, N., Zhang, Z. G., and Zaloga, C., Induction of Dna fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats, Stroke, 26 (1995) 1252–1257.PubMedGoogle Scholar
  183. 183.
    Li, Y., Chopp, M., Jiang, N., and Zaloga, C., In situ detection of DNA fragmetnation after focal cerebral ischemia in mice, Mol. Brain Res., 28 (1995) 164–168.PubMedGoogle Scholar
  184. 184.
    Li, Y., Chopp, M., Jiang, N., Yao, F., and Zaloga, C., Temporal profile of in situ DNA fragmentation after trasnient middle cerebral artery occlusion in the rat, J. Cereb. Blood Flow Metab., 15 (1995) 389–397.PubMedGoogle Scholar
  185. 185.
    MacManus, J. P., Hill, I. E., Huang, Z. G., Rasquinha, I., Xue, D., and Buchan, A. M., DNA damage consistent with apoptosis in transient focal ischaemic neocortex, Neuroreport, 5 (1994) 493–496.PubMedGoogle Scholar
  186. 186.
    Tominaga, T., Kure, S., Narisawa, K., and Yoshimoto, T., Endonuclease activation following focal ischmic injury in the rat brain, Brain Res., 608 (1993) 21–26.PubMedGoogle Scholar
  187. 187.
    Charriaut-Marlangue, C., Margaill, I., Plotkine, M., and Ben-Ari, Y., Early endonuclease activation following reversible focal ischemia in the rat brain, J. Cereb. Blood Flow Metab., 15 (1995) 385–388.PubMedGoogle Scholar
  188. 188.
    Linnik, M. D., Miller, J. A., Sprinklecavallo, J., Mason, P. J., Thompson, F. Y., Montgomery, L. R., and Schroeder, K. K., Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion, Mol. Brain Res., 32 (1995) 116–124.PubMedGoogle Scholar
  189. 189.
    Linnik, M. D., Zobrist, R. H., and Hatfield, M. D., Evidence supporting a role for pro- grammed cell death in focal cerebral ischemia in rats, Stroke, 24 (1993) 2002–2009.PubMedGoogle Scholar
  190. 190.
    Iizuka, H., Sakatani, K., and Young, W., Neural damage in the rat thalamus after cortical infarcts, Stroke, 21 (1990) 790–794.PubMedGoogle Scholar
  191. 191.
    Yamada, K., Kinoshita, A., Kohmura, E., Sakaguchi, T., Taguchi, J., Kataoka, K., and Hayakawa, T., Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction, J. Cereb. Blood Flow Metab., 11 (1991) 472–478.PubMedGoogle Scholar
  192. 192.
    Schroeter, M., Schiene, K., Kraemer, M., Hagemann, G., Weigel, H., Eysel, U. T., Witte, O. W., and Stoll, G., Astroglial responses in photochemically induced focal ischemia of the rat cortex, Exp. Brain Res., 106 (1995) 1–6.PubMedGoogle Scholar
  193. 193.
    Li, Y., Chopp, M., Zhang, Z. G., and Zhang, R. L., Expression of glial fibrillary acidic protein in areas of focal cerebral ischemia accompanies neuronal expression of 72-kDa heat shock protein, J. Neurol. Sci., 128 (1995) 134–412.PubMedGoogle Scholar
  194. 194.
    Chen, H., Chopp, M., Schultz, L., Bodzin, G., and Garcia, J. H., Sequential neuronal and astrocytic changes after transient middle cerebral artery occlusion in the rat, J. Neurol. Sci., 118 (1993) 109–116.PubMedGoogle Scholar
  195. 195.
    Korematsu, K., Goto, S., Nagahiro, S., and Ushio, Y., Microglial response to transient focal cerebral ischemia: an immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody, J. Cereb. Blood Flow Metab., 14 (1994) 825–830.PubMedGoogle Scholar
  196. 196.
    Gehrmann, J., Yamashita, K., Back, T., Kreutzberg, G. W., and Wiessner, C., The microglial reaction in focal ischemia: an early generalized response not attenuable by post-ischaemic pharmacological intervention, J. Cereb. Blood Flow Metab., 15 (Suppl. 1) (1995) S353.Google Scholar
  197. 197.
    Gehrmann, J., Mies, G., Bonnekoh, P., Banati, R., lijima, T., Kreutzberg, G. W., and Hossmann, K.-A., Microglial reaction in the rat cerebral cortex induced by cortical spreading depression, Brain Pathol., 3 (1993) 11–17.PubMedGoogle Scholar
  198. 198.
    Morioka, T., Kalehua, A. N., and Streit, W. J., Characterization of microglial reaction after middle cerebral artery occlusion in rat brain, J. Comp. Neurol., 327 (1993) 123–132.PubMedGoogle Scholar
  199. 199.
    Cohen, J. S., Oligonucleotides as therapeutic agents, Pharmac. Ther., 52 (1991) 211–225.Google Scholar
  200. 200.
    Aguzzi, A., Brandner, S., Sure, U., Ruedi, D., and Isenmann, S., Transgenic and knockout mice: models of neurological disease, Brain Pathol., 4 (1994) 3–20.PubMedGoogle Scholar
  201. 201.
    Liu, P. K., Salminen, A., He, Y. Y., Jiang, M. H., Xue, J. J., Liu, J. S., and Hsu, C. Y., Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA, Ann. Neurol., 36 (1994) 566–576.PubMedGoogle Scholar
  202. 202.
    Wahlestedt, C., Golanov, E., Yamamoto, S., Yee, F., Ericson, H., Yoo, H., Inturrisi, C. E., and Reis, D. E., Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischemic infarction, Nature, 363 (1993) 260–263.PubMedGoogle Scholar
  203. 203.
    Barone, F. C., Knudsen, D. J., Nelson, A. H., Feuerstein, G. Z., and Willette, R. N., Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy, J. Cereb. Blood Flow Metab., 13 (1993) 683–692.PubMedGoogle Scholar
  204. 204.
    Garcia, I., Martinou, I., Tsujimoto, Y., and Martinou, J.-C., Prevention of programmed cell death of sympathetic neurons by the bc1–2 proto-oncogene, Science, 258 (1992) 302–304.PubMedGoogle Scholar
  205. 205.
    Chan, P. H., Epstein, C. J., Kinouchi, H., Kamii, H., Imaizumi, S., Yang, G., Chen, S. F., Gafni, J., and Carlson, E., SOD-1 transgenic mice as a model for studies of neuroprotection in stroke and brain trauma, Ann. New York Acad. Sci., 738 (1994) 93–103.Google Scholar
  206. 206.
    Huang, Z., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C., and Moskowitz, M. A., Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase, Science, 265 (1994) 1883–1885.PubMedGoogle Scholar
  207. 207.
    MacMillan, V., Judge, D., Wiseman, A., Settles, D., Swain, J., and Davis, J., Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage, Stroke, 24 (1993) 1735–1739.PubMedGoogle Scholar
  208. 208.
    Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., and Rajewsky, K., Deletion of a DNA polymerase 13 gene segment in T cells using cell type specific gene targeting, Science, 265 (1994) 103–106.PubMedGoogle Scholar
  209. 209.
    Gossen, M., Freundlieb, S., G. B., Müller, G., Hillen, W., and Bujard, H., Transcriptional activation by tetracyclines in mammalian cells, Science, 268 (1995) 1766–1769.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Christoph Wiessner
  • Konstantin-Alexander Hossmann

There are no affiliations available

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