African Histoplasmosis

Part of the Infectious Disease book series (ID)


The dimorphic fungus Histoplasma capsulatum var. duboisii is the etiologic agent of African histoplasmosis. The disease has been limited largely to Central and Western Africa (especially Nigeria), and some other localized areas (the province of Natal in South Africa) (1–5). Abrucio Neto et al. (6) described a case of African histoplasmosis diagnosed in Brasil. The patient, an immigrant from Angola, had cutaneous lesions. Earlier, Oddo et al. (7) reported the first case of Histoplasma duboisii in South America. Again, the patient lived in Africa before moving to Chile. Manfredi et al. (8) examined the epidemiologic and clinical features of African histoplasmosis in Europe and the role played by the emergence of the HIV pandemic and the progressively increasing rate of travel and immigration as risk factors for this infection in other part of the world (9).


Cutaneous Lesion Cutaneous Manifestation Molluscum Contagiosum Oral Itraconazole Irreversible Renal Damage 
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  1. 1.
    Bayles, M. A. H. Tropical mycoses. Chemotherapy, 38 (Suppl. 1), 27, 1992.PubMedCrossRefGoogle Scholar
  2. 2.
    Gross, M. L. and Millikan, L. E. Deep fungal infections in the tropics. Dermatol. Clin., 12, 695, 1994.PubMedGoogle Scholar
  3. 3.
    Vanbreuseghem, R. Reflexions sur l’histoplasmose africaine at l’histoplasmose americaine. Mykosen, 25, 171, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Williams, A. O., Lawson, E. A., and Lucas, A. O. African histoplasmosis due to Histoplasma duboisii. Arch. Pathol., 92, 306, 1971.Google Scholar
  5. 5.
    Muotoe-Okafor, F. A., Gugnani, H. C., Gugnani, A., and Okafor, G. Antibodies to antigens of Histoplasma, Blastomyces and Candida in HIV patients and carriers in Nigeria. Mycoses, 43, 173–175, 2000.PubMedCrossRefGoogle Scholar
  6. 6.
    Abrucio Neto, L., Takahashi, M. D. F., Salebian, A., and Cuce, L. C. African histoplasmosis: report of the first case in Brasil and treatment with itraconazole. Rev. Inst. Med. Trop. Sao Paolo, 35, 295, 1993.Google Scholar
  7. 7.
    Oddo, D., Etchart, M., and Thompson, L. Histoplasma duboisii (African histoplasmosis). An African case reported from Chile with ultrastructural study. Pathol. Res. Pract., 186, 514, 1990.PubMedCrossRefGoogle Scholar
  8. 8.
    Manfredi, R., Mazzoni, A., Nanetti, A., and Chido, F. Histoplasmosis capsulati and duboisii in Europe: the impact of the HIV pandemic, travel and immigration. Eur. J. Epidemiol., 10, 675–681, 1994.PubMedCrossRefGoogle Scholar
  9. 9.
    Nethercott, J. R., Schachter, R. K., Givan, K. F., and Ryder, D. E. Histoplasmosis due to Histoplasma capsulatum var. duboisii in a Canadian immigrant. Arch. Dermatol., 114, 595–598, 1978.PubMedCrossRefGoogle Scholar
  10. 10.
    Gugnani, H. C., Muotoe-Okafor, F. A., Kaufman, L., and Dupont, B. A natural focus of Histoplasma capsulatum var. duboisii is a bat cave. Mycopathologia 127, 151–157, 1994.PubMedCrossRefGoogle Scholar
  11. 11.
    Butler, T. M. and Hubbard, G. B. An epizootic of histoplasmosis duboisii (African histoplasmosis) in an American baboon colony. Lab. Anim. Sci., 41, 407–410, 1991.PubMedGoogle Scholar
  12. 12.
    Butler, T. M., Gleiser, C. A., Bernal, J. C., and Ajello, L. Case of disseminated African histoplasmosis in a baboon. J. Med. Primatol., 17, 153–161, 1988.PubMedGoogle Scholar
  13. 13.
    Kwon-Chung, K. J. and Bennett, J. E. Medical Mycology. Lea and Febiger, Philadelphia, 487, 1992.Google Scholar
  14. 14.
    Aubry, P. and Lecamus, J. L. Les histoplasmoses. Med. Trop. (Mars.), 46, 229–237, 1986.Google Scholar
  15. 15.
    Dupont, B., Drouhet, E., and Lapresle, C. Histoplasmosis généralisée a Histoplasma duboisii. Nouv. Presse Med., 3, 1005, 1974.Google Scholar
  16. 16.
    Seeliger, H. P. R., Kracht, J., and Bikfalvi, A. Grosszellige (afrikanische) histoplasmamykose der lunge. Dtsch. Med. Wochenschr., 105, 609, 1980.PubMedCrossRefGoogle Scholar
  17. 17.
    Cockshott, W. P. and Lucas, A. O. Histoplasma duboisii. Q. J. Med., 33, 223, 1964.PubMedGoogle Scholar
  18. 18.
    Williams, A. O., Lawson, E. A., and Lucas, A.O. African histoplasmosis due to Histoplasma duboisii. Arch. Pathol., 92, 306, 1971.Google Scholar
  19. 19.
    Jones, R. C. and Goodwin, R. A. Jr. Histoplasmosis of bone. Am. J. Med., 70, 864–866, 1981.CrossRefGoogle Scholar
  20. 20.
    Bankole Sanni, R., Denoulet, C., Coulibaly, B., et al. A propos d’un cas ivoirien d’histoplasmose osseuse et cutanee a Histoplasma capsulatum var. duboisii. Bull. Soc. Pathol. Exot., 91, 151–153, 1998.Google Scholar
  21. 21.
    Onwuasoigwe, O. and Gugnani, H. C. African histoplasmosis: osteomyelitis of the radius. Mycoses, 41, 105–107, 1998.PubMedCrossRefGoogle Scholar
  22. 22.
    Lucas, A. O. Cutaneous manifestations of African histoplasmosis. Br. J. Dermatol., 82, 435, 1970.PubMedCrossRefGoogle Scholar
  23. 23.
    Khalil, M., Iwatt, A. R., and Gugnani, H. C. African histoplasmosis masquerading as carcinoma of the colon. Report of a case and review of literature. Dis. Colon Rectum, 32, 518–520, 1989.PubMedCrossRefGoogle Scholar
  24. 24.
    Olasoji, H. O., Pindiga, U. H., and Adeosun, O. O. African histoplasmosis lip carcinoma: case report. East Afr. Med. J., 76, 475–476, 1999.PubMedGoogle Scholar
  25. 25.
    Dietrich, P. Y., Billie, J., Fontolliet, C., and Regamey, C. Histoplasmose disseminee a Histoplasma capsulatum chez un patient presentantun syndrome d’immunodeficience acquise (SIDA). Schweiz. Med. Wochenschr., 117, 1289–1296, 1987.PubMedGoogle Scholar
  26. 26.
    Lucas, A. O. Cutaneous manifestations of African histoplasmosis. Br. J. Dermatol., 82, 435, 1970.PubMedCrossRefGoogle Scholar
  27. 27.
    Drouhet, E. and Dupont, B. Laboratory and clinical assessment of ketoconazole in deep-seated mycoses. Am. J. Med., 74 (1B), 30–47, 1983.PubMedCrossRefGoogle Scholar
  28. 28.
    Drouhet, E. and Dupont, B. Chronic mucocutaneous candidosis and other superficial and systemic mycoses successfully treated with ketoconazole. Rev. Infect. Dis., 2, 606–619, 1980.PubMedCrossRefGoogle Scholar
  29. 29.
    Mabey, D. C. W. and Hay, R. J. Further studies on the treatment of African histoplasmosis with ketoconazole. Trans. R. Soc. Trop. Med. Hyg., 83, 560, 1989.PubMedCrossRefGoogle Scholar
  30. 30.
    N’dri Oka, D., Varlet, G., Kakou, M., Zunon-Kipre, Y., Broalet, E., Ba Zeze, V. Spondylodiscitis due to Histoplasma duboisii. Report of two cases and review of the literature. Neurochirurgie, 47, 431–434, 2011.Google Scholar
  31. 31.
    De Rosso, J. Q. and Gupta, A. K. Oral itraconazole therapy for superficial, subcutaneous, and systemic infections. A panoramic view. Postgrad. Med., Spec. No: 46–52, 1999.Google Scholar
  32. 32.
    Lortholary, O., Denning, D. W., Dupont, B. Endemic mycoses: a treatment update. J. Antimicrob. Chemother., 43, 321–331, 1999.PubMedCrossRefGoogle Scholar
  33. 33.
    Chandenier, J., Goma, D., Moyen, G., et al. Histoplasmose africaine a Histoplasma capsulatum var. duboisii: liens avec le SIDA a propos de cas congolais recents. Sante, 5, 227–234, 1995.PubMedGoogle Scholar
  34. 34.
    Dupont, B. and Drouhet, E. Early experience with itraconazole in vitro and in patients: pharmacokinetic studies and clinical results. Rev. Infect. Dis., 9 (Suppl. 1), S71 — S76, 1987.PubMedCrossRefGoogle Scholar
  35. 35.
    Drouhet, E. African histoplasmosis. Baillieres Clin. Trop. Med. Commun. Dis., 4, 89, 1989.Google Scholar
  36. 36.
    Eichmann, A. and Schar, G. Afrikanische histoplasmose bei patient mit HIV-2 infektion. Schweiz. Med. Wochenschr., 126, 765–769, 1996.PubMedGoogle Scholar
  37. 37.
    Onwuasoigwe, O. Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis. Int. Orthop., 23, 8284, 1999.CrossRefGoogle Scholar
  38. 38.
    Ajayi, B. G. K., Osuntokun, B., Olurin, O., Kale, O. O., and Junaid, T. A. Orbital histoplasmosis due to Histoplasma capsulatum var. duboisii: successful treatment with septrin. J. Trop. Med. Hyg., 89, 179–187, 1986.PubMedGoogle Scholar
  39. 39.
    MacLeod, W. M. Treatment of histoplasmosis. Lancet, 2, 363, 1970.PubMedCrossRefGoogle Scholar
  40. 40.
    Brown, K. G. E., Molesworth, B. D., Boerrigter, F. G. G., and Tozer, R. A. Disseminated histoplasmosis duboisii in Malawi partial response to sulphonamide/trimethoprim combination. East Afr. Med. J., 51, 584, 1974.PubMedGoogle Scholar
  41. 41.
    Egere, J. U., Gugnani, H. C., Okoro, A. N., and Suseelan, A. V. African histoplasmosis in Eastern Nigeria: report of two culturally proven cases treated with septrin and amphotericin B. J. Trop. Med. Hyg., 81, 225, 1978.PubMedGoogle Scholar
  42. 42.
    Salkind, A. R. Acute delirium induced by intravenous trimethoprim-sulfamethoxazole therapy in a patient with the acquired immunodeficiency syndrome. Hum. Exp. Toxicol., 19, 149–151, 2000.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2003

Authors and Affiliations

  1. 1.National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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