Infectious Disease in the Aging pp 225-242 | Cite as
Viral Infections
Abstract
Of the viral infections that cause disease in older adults, influenza is recognized as one of the greatest causes of morbidity and mortality. Pneumonia and influenza together comprise the fifth leading causes of death in persons aged 65 yr and older. Influenza viruses are enveloped ribonucleic acid (RNA) viruses that are classified as A, B, or C, based on stable internal proteins (1). The virus contains two major surface proteins, hemagglutinin (H) and neuraminidase (N), which can undergo minor antigenic changes leading to yearly epidemics or major changes resulting in influenza pandemics. Currently, there are two circulating influenza A viruses, H1N1 and H3N2, in addition to influenza B, present in the United States. H1N1 viruses do not appear to cause serious problems in older persons, possibly due to previous immunity (2).
Keywords
Nursing Home Respiratory Syncytial Virus Herpes Zoster Attack Rate Respiratory Syncytial Virus InfectionPreview
Unable to display preview. Download preview PDF.
References
- 1.Betts, R. (1995) Influenza, in Principles and Practices of Infectious Diseases ( Mandell, G. L., Bennett, J. F., and Dolin, R., eds.), Churchill Livingston, New York, pp. 1546–1567.Google Scholar
- 2.Cate, T. R. (1987) Clinical manifestations and consequences of influenza. Am. J. Med. 82, 15–19.PubMedCrossRefGoogle Scholar
- 3.Glezen, W. P. and Couch, R. B. (1978) Interpandemic influenza in the Houston area, 1974–1976. N. Engl. J. Med. 298, 587–592.PubMedCrossRefGoogle Scholar
- 4.Perrotta, D. M., Decker, M., and Glezen, W. P. (1985) Acute respiratory disease hospitalizations as a measure of impact of epidemic influenza. Am. J. Epidemiol. 122, 468–476.PubMedGoogle Scholar
- 5.Barker, W. H. and Mullooly, J. P. (1980) Impact of epidemic A influenza in a defined adult population. Am. J. Epidemiol. 112, 798–811.PubMedGoogle Scholar
- 6.Goodman, R. A., Orenstein, W. A., Munro, T. F., et al. (1982) Impact of influenza A in a nursing home. JAMA 247, 1451–1453.PubMedCrossRefGoogle Scholar
- 7.McBean, A. M., Babish, J. D., and Warren, J. L. (1993) The impact and cost of influenza in the elderly. Arch. Intern. Med. 153, 2105–2111.PubMedCrossRefGoogle Scholar
- 8.Barker, W. H., Borisute, H., and Cox, C. (1998) A study of the impact of influenza on the functional status of frail older people. Arch. Intern. Med. 158, 645–650.PubMedCrossRefGoogle Scholar
- 9.Schirm, J., Luijt, D. S., Pastoor, G. W., et al. (1992) Rapid detection of respiratory viruses using mixtures of monoclonal antibodies on shell viral cultures. J. Med. Virol. 38, 147–151.PubMedCrossRefGoogle Scholar
- 10.Waner, J. L., Todd, S. J., Shalaby, H., et al. (1991) Comparison of Directigen FLU-A with viral isolation and direct immunofluorescence for the rapid detection and identification of influenza A virus. J. Clin. Microbiol. 29, 479–482.PubMedGoogle Scholar
- 11.Leonardi, G. P., Leib, H., Birkhead, G. S., et al. (1994) Comparison of rapid detection methods for influenza A virus and their value in health care management of institutionalized geriatric patients. J. Clin. Microbiol. 32, 70–74.PubMedGoogle Scholar
- 12.Douglas, R. G. (1990) Prophylaxis and treatment of influenza. N. Engl. J. Med. 322, 443–450.PubMedCrossRefGoogle Scholar
- 13.Hayden, F. G., Sperber, S. J., Belshe, R. B., et al. (1991) Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob. Agent Chemother. 35, 1741–1747.CrossRefGoogle Scholar
- 14.Center for Disease Control and Prevention (1999) Neuraminadase inhibitors for the treatment of influenza A and B infection. M.M.W.R. 48 (No. RR-14), 1–9.Google Scholar
- 15.Schilling, M., Povinelli, L., Krause, P., et al. (1998) Efficacy of zanamivir for chemoprophylaxis of nursing home influenza outbreaks. Vaccine 16, 1771–1774.PubMedCrossRefGoogle Scholar
- 16.Hayden, F. G., Osterhaus, A. D., Treanor, J. J., et al. (1997) Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. J. Med. 337, 874–880.Google Scholar
- 17.Anonymous (1996) Prevention and control of influenza - recommendations of the Advisory Committee on Immunization Practices. M.M.W.R. 45 RR-5, 1–24.Google Scholar
- 18.Gravenstein, S., Miller, B. A., and Drinka, P. (1992) Prevention and control of influenza A outbreaks in long term care facilities. Infect. Control Hosp. Epidemiol. 13, 49–54.PubMedCrossRefGoogle Scholar
- 19.Nichol, K. L., Margolis, K. L., Wuorenma, J., et al. (1994) The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N. Eng. J. Med. 331, 778–784.CrossRefGoogle Scholar
- 20.Nicholson, K. G. (1996) Impact of influenza and respiratory syncytial virus on mortality in England and Wales from January 1975 to December 1990. Epidemiol. Infect. 116, 51–63.PubMedCrossRefGoogle Scholar
- 21.Falsey, A. R., Cunningham, C. K., Barker, W. H., et al. (1995) Respiratory syncytial virus and influenza A infections in the hospitalized elderly. J. Infect. Dis. 172, 389–394.PubMedCrossRefGoogle Scholar
- 22.Fleming, D. M. and Cross, K. W. (1993) Respiratory syncytial virus or influenza? Lancet 342, 1507–1510.PubMedCrossRefGoogle Scholar
- 23.Mathur, U., Bentley, D. W., and Hall, C. B. (1980) Concurrent respiratory syncytial virus and Influenza A infections in the institutionalized elderly and chronically ill. Ann. Intern. Med. 93, 49–52.PubMedCrossRefGoogle Scholar
- 24.Centers for Disease Control (1977) Epidemiologic notes and reports: respiratory syncytial virus -Missouri. M.M.W.R. 26, 351.Google Scholar
- 25.Falsey, A. R. (1991) Noninfluenza respiratory virus infection in long-term care facilities. Infect. Control Hosp. Epidemiol. 12, 602–608.PubMedCrossRefGoogle Scholar
- 26.Agius, G., Dindinaud, G., Biggar, R. J., et al. (1990) An epidemic of respiratory syncytial virus in elderly people: clinical and serological findings. J. Med. Virol. 30, 117–127.PubMedCrossRefGoogle Scholar
- 27.Wald, T. G., Miller, B. A., Shult, P., et al (1995) Can respiratory syncytial virus and influenza A be distinguished clinically in institutionalized older persons? J. Am. Geriatr. Soc. 43, 170–174.PubMedGoogle Scholar
- 28.Osterweil, D. and Norman, D. (1990) An outbreak of an influenza-like illness in a nursing home. J. Am. Geriatr. Soc. 38, 659–662.PubMedGoogle Scholar
- 29.Public Health Laboratory Service Communicable Diseases Surveillance Centre. (1983) Respiratory syncytial virus infection in the elderly 1976–1982. Br. Med. J. 287, 1618–1619.Google Scholar
- 30.Falsey, A. R., Treanor, J. J., Betts, R. F., et al. (1992) Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings. J. Am. Geriatr. Soc. 40, 115–119.PubMedGoogle Scholar
- 31.Sorvillo, F. J., Huie, S. F., Strassburg, M. A., et al. (1984) An outbreak of respiratory syncytial virus pneumonia in a nursing home for the elderly. J. Infect. 9, 252–256.PubMedCrossRefGoogle Scholar
- 32.Garvie, D. G. and Gray, J. (1980) Outbreak of respiratory syncytial virus infection in the elderly. Br. Med. J. 281, 1253–1254.PubMedCrossRefGoogle Scholar
- 33.Falsey, A. R., McCann, R. M., Hall, W. J., et al. (1995) Acute respiratory tract infection in daycare centers for older persons. J. Am. Geriatr. Soc. 43, 30–36.PubMedGoogle Scholar
- 34.Dowell, S. F., Anderson, L. J., Gary, H. E. J., et al. (1996) Respiratory syncytial virus is an important cause of community acquired pneumonia among hospitalized adults. J. Infect. Dis. 174, 456–462.PubMedCrossRefGoogle Scholar
- 35.Han, L. L., Alexander, J. P., and Anderson, L. J. (1999) Respiratory syncytial virus pneu- monia among the elderly: an assessment of disease burden. J. Infect. Dis. 179, 25–30.PubMedCrossRefGoogle Scholar
- 36.Falsey, A. R., McCann, R. M., Hall, W. J., et al. (1996) Evaluation of four methods for the diagnosis of respiratory syncytial virus infection in older adults. J. Am. Geriatr. Soc. 44, 71–73.PubMedGoogle Scholar
- 37.Vikerfors, T., Grandien, M., Johansson, M., et al. 1988 ) Detection of an immunoglobulin M response in the elderly for early diagnosis of respiratory syncytial virus infection. J. Clin. Microbiol. 26, 808–811.PubMedGoogle Scholar
- 38.Falsey, A. R. (1996) Viral respiratory infections, tract infections in elderly persons. Infect. Dis. Clin. Pract. 5, 53–58.CrossRefGoogle Scholar
- 39.Aylward, B. R. and Burdge, D. R. (1991) Ribavirin therapy of adult respiratory syncytial virus pneumonitis. Arch. Intern. Med. 2303, 2304.Google Scholar
- 40.Graman, P. S. and Hall, C. B. (1989) Epidemiology and control of nosocomial viral infections. Infect. Dis. Clin. North Am. 3, 815–841.PubMedGoogle Scholar
- 41.Wenzel, R. P., McCormick, D. P., and Beam, W. E. J. (1972) Parainfluenza pneumonia in adults. DAMA 221, 294, 295.Google Scholar
- 42.Fransen, H., Heigl, Z., Wolontis, S., et al. (1969) Infections with viruses in patients hospitalized with acute respiratory illness, Stockholm 1963–1967. Scand J. Infect. Dis. 1, 127–136.PubMedGoogle Scholar
- 43.Monto, A. S. and Sullivan, K. M. (1993) Acute respiratory illnesses in the community: frequency of illness and the agents involved. Epidemiol. Infect. 110, 145–160.PubMedCrossRefGoogle Scholar
- 44.Public Health Laboratory Service Communicable Disease Surveillance Centre (1983) Parainfluenza infections in the elderly 1976–82. Br. Med. J. 287, 1619.Google Scholar
- 45.Epidemiologic Notes and Reports. (1978) Parainfluenza outbreaks in extended care facilities-United States. M.M.W.R. 27, 475–476.Google Scholar
- 46.Glasgow, K. W., Tamblyn, S. E., and Blair, G. (1995) A respiratory outbreak due to parainfluenza virus type 3 in a home for the aged. Ontario Can. Comm. Dis. Rep. 21, 57–61.Google Scholar
- 47.Gwaltney, J. M., Hendley, J. O., Simon, G., et al. (1966) Rhinovirus infections in an industrial population-I. the occurrence of illness. N. Engl. J. Med. 275, 1261–1268.PubMedCrossRefGoogle Scholar
- 48.Monto, A., Bryan, E. R., and Ohmit, S. (1987) Rhinovirus infections in Tecumseh, Michigan: frequency of illness and number of serotypes. J. Infect. Dis. 156, 43–49.PubMedCrossRefGoogle Scholar
- 49.Gwaltney, J. M. (1995) Rhinoviruses, in Principles and Practices of Infectious Diseases ( Mandell, G. L., Bennett, J. E., and Dolin, R., eds.), Churchill Livingstone, New York, pp. 1656–1662.Google Scholar
- 50.Nicholson, K. G., Kent, J., Hammersley, V., et al. (1996) Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study. Br. Med. J. 313, 1119–1123.CrossRefGoogle Scholar
- 51.Wald, T. G., Shutt, P., Krause, P., Miller, et al. (1995) A rhinovirus outbreak among residents of a long-term care facility. Ann. Intern. Med. 123, 588–593.PubMedCrossRefGoogle Scholar
- 52.Falsey, A. R., McCann, R. M., Hall, W. J., et al. (1997) The common cold in frail older persons: impact of rhinovirus and coronavirus in a senior daycare center. J. Am. Geriatr. Soc. 45, 706–711.PubMedGoogle Scholar
- 53.Turner, R. B., Wecker, M. T., Pohl, G., et al. (1999) Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection. JAMA 281, 1797–1804.PubMedCrossRefGoogle Scholar
- 54.Larson, H. E., Reed, S. E.,and Tyrrell, D. A. J. (1980) Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J. Med. Virol. 5, 221–229.Google Scholar
- 55.McIntosh, K., Kapikian, A. Z., Turner, H. C., et al. (1970) Seroepidemiologic studies of coronavirus infection in adults and children. Am. J. Epidemiol. 91, 585–592.PubMedGoogle Scholar
- 56.Wiselka, M. J., Kent, J., Cookson, J. B., et al. (1993) Impact of respiratory virus infection in patients with chronic chest disease. Epidemiol. Infect. 111, 337–346.PubMedCrossRefGoogle Scholar
- 57.Nicholson, K. G., Kent, J., Hammersley, V., et al. (1997) Acute viral infections of upper respiratory tract in elderly people living in the community; comparative, prospective, population based study of disease burden. Br. Med. J. 315, 1060–1064.CrossRefGoogle Scholar
- 58.Nicholson, K. G., Baker, D. J., Farquhar, A., et al. (1990) Acute upper respiratory tract viral illness and influenza immunization in homes for the elderly. Epidemiol. Infect. 105, 609–618.PubMedCrossRefGoogle Scholar
- 59.Melnick, J. L. (1995) History and epidemiology of hepatitis A virus. J. Infect. Dis. 171, S2 - S8.PubMedCrossRefGoogle Scholar
- 60.Marcus, E. and Tur-Kaspa, R. (1997) Viral hepatitis in older adults. J. Am. Geriatr. Soc. 45, 755–763.PubMedGoogle Scholar
- 61.Alter, M. J. and Mast, E. E. (1994) The epidemiology of viral hepatitis in the United States. Gastroenterol. Clin. North Am. 23, 437–455.PubMedGoogle Scholar
- 62.MacMahon, M. and James, O. F. W. (1994) Liver disease in the elderly. J. Clin. Gastroenterol. 18, 330–334.CrossRefGoogle Scholar
- 63.Bader, T. F. (1996) Hepatitis A vaccine. Am. J. Gastroenterol. 91, 217–222.PubMedGoogle Scholar
- 64.Clemens, R., Safary, A., Hepburn, A., et al. (1995) Clinical experience with an inactivated hepatitis A vaccine. J. Infect. Dis. 171, S44–549.PubMedCrossRefGoogle Scholar
- 65.Scheifele, D. W. and Bjornson, G. J. (1993) Evaluation of inactivated hepatitis A vaccine in Canadians 40 years of age or more. Can. Med. Assoc. J. 148, 551–555.Google Scholar
- 66.Goodson, J. D., Taylor, P. A., Campion, E. W., et al. (1982) The clinical course of acute hepatitis in the elderly patient. Arch. Intern. Med. 142, 1485–1488.PubMedCrossRefGoogle Scholar
- 67.Schreiber, G. B., Busch, M. P., Kleinman, S. H., et al. (1996) The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. N. Engl. J. Med. 334, 1685–1690.PubMedCrossRefGoogle Scholar
- 68.Simor, A. E., Gordon, M., and Bishai, F. R. (1992) Prevalence of hepatitis B surface antigen, hepatitis C antibody, and HIV-1 antibody among residents of a long-term-care facility. J. Am. Geriatr. Soc. 40, 218–220.PubMedGoogle Scholar
- 69.Sallie, R. and DiBisceglie, A. M. (1994) Viral hepatitis and hepatocellular carcinoma. Gastroenterol. Clin. North Am. 23, 567–579.PubMedGoogle Scholar
- 70.Floreani, A., Bertin, T., Soffiati, G., et al. (1992) Anti-hepatitis C virus in the elderly: a seroepidemiological study in a home for the aged. Gerontology 38, 214–216.PubMedCrossRefGoogle Scholar
- 71.Brind, A. M., Watson, J. P., James, O. F. W., et al. (1996) Hepatitis C virus infection in the elderly. Q. J. Med. 89, 291–296.CrossRefGoogle Scholar
- 72.Horiike, N., Masumoto, T., Nakanishi, K., et al. (1995) Interferon therapy for patients more than 60 years of age with chronic hepatitis C. J. Gastroenterol. Hepatol. 10, 246–249.PubMedCrossRefGoogle Scholar
- 73.Sampietro, M., Caputo, L., Corbetta, N., et al. (1998) Hepatitis G virus infection in the elderly. Ital. J. Gastroenterol. Hepatol. 30, 524–527.PubMedGoogle Scholar
- 74.Bennett, R. and Greenough, W.B. (1993) Approach to acute diarrhea in the elderly. Gastroenterol. Clin. North Am. 22, 517–533.PubMedGoogle Scholar
- 75.Humphrey, T. J., Cruickshank, J. G., and Cubitt, W. D. (1984) An outbreak of calicivirus associated gastroenteritis in an elderly persons home. A possible zoonosis? J. Hygiene 93, 293–299.CrossRefGoogle Scholar
- 76.Jiang, X., Turf, E., Hu, J., et al. (1996) Outbreaks of gastroenteritis in elderly nursing homes and retirement facilities associated with human calciviruses. J. Med. Virol. 50, 335–341.PubMedCrossRefGoogle Scholar
- 77.Marrie, T., Lee, S., Faulkner, R., et al. (1982) Rotavirus infection in a geriatric population. Arch. Intern. Med. 142, 313–316.PubMedGoogle Scholar
- 78.Cubitt, W. D. and Holzel, H. (1980) An outbreak of rotavirus infection in a long-stay ward of a geriatric hospital. J. Clin. Pathol. 33, 306–308.PubMedCrossRefGoogle Scholar
- 79.Halvorsrud, J. and Orstavik, I. (1980) An epidemic of rotavirus-associated gastroenteritis in a nursing home for the elderly. Scand. J. Infect. Dis. 12, 161–164.PubMedGoogle Scholar
- 80.Perez-Schael, I., Guntinas, M. J., Perez, et al. (1997) Efficacy of the rhesus rotavirus-based quadrivalent vaccine in infants and young children in Venezuela. N. Engl. J. Med. 337, 1181–1187.PubMedCrossRefGoogle Scholar
- 81.El-Sadr, W. and Gettler, J. (1995) Unrecognized human immunodeficiency virus infection in the elderly. Arch. Intern. Med. 155, 184–186.PubMedCrossRefGoogle Scholar
- 82.Gaeta, T. J., LaPolla, C., and Melendez, E. (1996) AIDS in the elderly: New York City vital statistics. J. Emerg. Med. 14, 19–23.PubMedCrossRefGoogle Scholar
- 83.Newcomer, V. D. (1997) Human immunodeficiency virus infection and acquired immunodeficiency syndrome in the elderly. Arch. Dermatol. 133, 1311, 1312.Google Scholar
- 84.Stall, R. and Catania, J. (1994) AIDS risk behaviors among late middle-aged and elderly Americans. Arch. Intern. Med. 154, 57–63.PubMedCrossRefGoogle Scholar
- 85.Sutin, D. G., Rose, D. N., Mulvihill, M., et al. (1993) Survival of elderly patients with transfusion-related acquired immunodeficiency syndrome. J. Am. Geriatr. Soc. 41, 214–216.PubMedGoogle Scholar
- 86.Kost, R. and Straus, S. (1996) Postherpetic neuralgia—pathogenesis, treatment, and prevention. N. Engl. Med. 335, 32–42.CrossRefGoogle Scholar
- 87.Donahue, J., Choo, P., Manson, J., et al. (1995) The incidence of herpes zoster. Arch. Intern. Med. 155, 1605–1609.PubMedCrossRefGoogle Scholar
- 88.Schmader, K. (1998) Postherpetic neuralgia in immunocompetent elderly people. Vaccine 16, 1768–1770.PubMedCrossRefGoogle Scholar
- 89.Whitley, R. J., Shukla, S., and Crooks, R. J. (1998) The identification of risk factors associated with persistent pain following herpes zoster. J. Infect. Dis. 178, S71–S75.PubMedCrossRefGoogle Scholar
- 90.Whitley, R., Weiss, H., Gnann, J., et al. (1996) Acyclovir with and without prednisone for the treatment of herpes zoster. Ann. Intern. Med. 125, 376–383.PubMedCrossRefGoogle Scholar
- 91.Dworkin, R. H., Boon, R. J., Griffin, D. R. G., et al. (1998) Postherpetic neuralgia: impact of famciclovir, age, rash severity, and acute pain in herpes zoster patients. J. Infect. Dis. 178, S76–S80.PubMedCrossRefGoogle Scholar
- 92.Schmader, K., van der Horst, C. M., and Klotman, M.E. (1989) Epstein-Barr virus and the elderly host. Rev. Infect. Dis. 11, 64–73.PubMedCrossRefGoogle Scholar
- 93.Horwitz, C. A., Henle, W., Henle, G., et al. (1976) Clinical and laboratory evaluation of elderly patients with heterophil-antibody positive infectious mononucleosis. Am. J. Med. 61, 333–339.PubMedCrossRefGoogle Scholar
- 94.Edelstein, H. and Knight, R. T. (1989) Epstein-Barr virus causing encephalitis in an elderly woman. South. Med. J. 82, 1192–1193F.PubMedCrossRefGoogle Scholar