Benign Fibrous, Fibrohistiocytic, and Myofibroblastic Lesions

  • Rajiv M. PatelEmail author
  • Reena Singh
  • Aaron M. Udager
  • Steven D. Billings


This chapter covers a large number of benign entities grouped together for convenience under the broad categories of fibrous, fibrohistiocytic, and myofibroblastic lesions. Fibrous lesions generally demonstrate a conspicuous increase in collagen production and varying numbers of fibroblastic spindle cells. “Fibrohistiocytic,” a somewhat enigmatic term, is a general descriptor for tumors containing a combination of spindle cells of putative fibroblastic, myofibroblastic, and/or primitive mesenchymal cell origin and histiocytes (bone marrow-derived tissue macrophages and dendritic cells). Myofibroblastic lesions are composed of spindle cells with combined features of smooth muscle cells and fibroblasts.


Fibroma Fibrous histiocytoma Dermatomyofibroma Fibromatosis Fibroblastic connective tissue nevus Fibrous hamartoma of infancy Xanthogranuloma Tenosynovial giant cell tumor Superficial acral fibromyxoma 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Rajiv M. Patel
    • 1
    Email author
  • Reena Singh
    • 2
  • Aaron M. Udager
    • 1
  • Steven D. Billings
    • 3
  1. 1.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Department of PathologyOregon Health and Science University School of MedicinePortlandUSA
  3. 3.Department of PathologyCleveland ClinicClevelandUSA

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