Genital Mesenchymal Tumors

  • Karen J. FritchieEmail author


A variety of mesenchymal tumors can arise in the cervix, vulvovaginal, and inguinoscrotal regions including lipomatous neoplasms, peripheral nerve sheath tumors, and sarcomas such as rhabdomyosarcoma. Consequently, this chapter will focus on lesions that solely or predominantly affect the soft tissues of the distal genital tract, beginning with the genital stromal tumors. This group includes fibroepithelial stromal polyp, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma, and aggressive angiomyxoma. As genital stromal tumors are notorious for significant morphologic and immunophenotypic overlap, key histologic features of each entity will be emphasized. Two rare lesions involving the vulva, prepubertal vulval fibroma and massive vulval edema, will also be reviewed. Finally, the chapter ends with a discussion of smooth muscle tumors of the external genitalia. Even though the morphology of smooth muscle tumors of the vulva, vagina, and scrotum is similar to those at other sites, each of these locations has unique criteria for distinguishing leiomyomas from leiomyosarcomas.


Cellular angiofibroma Fibroepithelial stromal polyp Aggressive angiomyxoma Myofibroblastoma Angiomyofibroblastoma Smooth muscle tumors 

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Mayo Clinic, Department of Laboratory Medicine and Pathology, Division of Anatomic PathologyRochesterUSA

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