Diuretics in Acute Kidney Injury

  • Sagar U. NigwekarEmail author
  • Sushrut S. Waikar


Outcomes associated with acute kidney injury (AKI) remain poor despite recent clinical advances. Because of limited clinical trial data, the use of diuretics for either prevention or enhancing recovery from AKI remains to be established. Still, diuretic use especially as a “stress test” in patients with AKI remains a common practice. In this chapter, the authors review the literature for diuretic and natriuretic agents in AKI management and discuss related mechanisms, experimental evidence, epidemiology, and randomized controlled trials. Implications for clinical practice regarding when to use these agents in AKI management are addressed.


Loop diuretics Mannitol Natriuretic peptides Renal replacement therapy Thiazide diuretics 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medicine/NephrologyMassachusetts General HospitalBostonUSA
  2. 2.Division of Renal MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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