Thyroid Cancer pp 419-425 | Cite as

Follow-Up Strategy in Papillary Thyroid Cancer

Chapter

Abstract

Effective surveillance for recurrent papillary thyroid cancer begins with an assessment of the risk of recurrence or death from disease. This information is used to determine an appropriate level of follow-up, which may vary from as little as an annual neck examination on replacement thyroid hormone therapy for very low-risk lesions to annual or semiannual thyrotropin (TSH)-stimulated whole-body scan (WBS) and thyroglobulin (Tg) measurement for high-risk patients. Additionally, the patients’ response to initial therapy further modulates the surveillance strategy. Effective follow-up is also contingent upon a current understanding of the strengths and limitations of the tools available for thyroid cancer surveillance. This chapter focuses on the rationale used to determine the method and frequency of follow-up for patients with papillary thyroid cancer (PTC) and reviews current guidelines regarding surveillance for persistent or recurrent disease.

Keywords

Papillary thyroid cancer Follow-up Risk level Recurrent disease Persistent disease Surveillance Imaging Serum thyroglobulin Clinical practice guidelines PTC 

References

  1. 1.
    Mazzaferri EL, Kloos RT. Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab. 2001;86:1447–63.CrossRefPubMedGoogle Scholar
  2. 2.
    Scuito R, Romano L, Rea S, et al. Natural history and clinical outcome of differentiated thyroid carcinoma: a retrospective analysis of 1503 patients treated at a single institution. Ann Oncol. 2009;20:1728–35.CrossRefGoogle Scholar
  3. 3.
    Solomon BL, Wartofsky L, Burman KD. Current trends in the management of well differentiated papillary thyroid carcinoma. J Clin Endocrinol Metab. 1996;81:333–9.PubMedGoogle Scholar
  4. 4.
    Kim S, Wei JP, Braveman JM, et al. Predicting outcome and directing therapy for papillary thyroid carcinoma. Arch Surg. 2004;139:390–4.CrossRefPubMedGoogle Scholar
  5. 5.
    Hay ID, Hutchinson ME, Gonzalez-Losada T, et al. Papillary thyroid microcarcinoma: a study of 900 cases observed in a 60-year period. Surgery. 2008;144:980–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Lin J-D, Chao T-C, Hsueh C, et al. High recurrent rate of multicentric papillary thyroid carcinoma. Ann Surg Oncol. 2009;16:2609–16.CrossRefPubMedGoogle Scholar
  7. 7.
    Ross DS, Litofsky D, Ain KB, et al. Recurrence after treatment of micropapillary thyroid cancer. Thyroid. 2009;19:1043–8.CrossRefPubMedGoogle Scholar
  8. 8.
    American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016; 26:1–133.Google Scholar
  9. 9.
    Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual. 7th ed. New York: Springer; 2009.Google Scholar
  10. 10.
    Tuttle RM, Tala H, Shah J, et al. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid. 2010;20:1341–9.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Cailleux AF, Baudin E, Travagli JP, et al. Is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer? J Clin Endocrinol Metab. 2000;85:175–8.CrossRefPubMedGoogle Scholar
  12. 12.
    Mazzaferri EL, Kloos RT. Is diagnostic iodine-131 scanning with recombinant human TSH useful in the follow-up of differentiated thyroid cancer after thyroid ablation? J Clin Endocrinol Metab. 2002;87:1490–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Robbins RJ, Chon JT, Fleisher M, et al. Is the serum thyroglobulin response to recombinant human thyrotropin sufficient, by itself, to monitor for residual thyroid carcinoma? J Clin Endocrinol Metab. 2002;87:3242–7.CrossRefPubMedGoogle Scholar
  14. 14.
    Torrens JI, Burch HB. Serum thyroglobulin measurement. Utility in clinical practice. Endocrinol Metab Clin N Am. 2001;30:429–67.CrossRefGoogle Scholar
  15. 15.
    Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 2003;88:1433–41.CrossRefPubMedGoogle Scholar
  16. 16.
    Tuttle RM, Ball DW, Byrd D, et al. Thyroid carcinoma. J Natl Compr Cancer Netw. 2010;8:1228–74.Google Scholar
  17. 17.
    Frasoldati A, Pesenti M, Gallo A, et al. Diagnosis of neck recurrences in patients with differentiated thyroid carcinoma. Cancer. 2003;97:90–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Torlontano M, Attard M, Crocetti U, et al. Follow-up of low risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting lymph node metastases. J Clin Endocrinol Metab. 2004;89:3402–7.CrossRefPubMedGoogle Scholar
  19. 19.
    Schlumberger M, Berg G, Cohen O, et al. Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Eur J Endocrinol. 2004;150:105–12.CrossRefPubMedGoogle Scholar
  20. 20.
    Torlontano M, Crocetti U, Augello G, et al. Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy. J Clin Endocrinol Metab. 2006;91:60–3.CrossRefPubMedGoogle Scholar
  21. 21.
    Durante C, Attard M, Torlontano M, et al. Identification and optimal postsurgical follow-up of patients with very low-risk papillary thyroid microcarcinomas. J Clin Endocrinol Metab. 2010;95:4882–8.CrossRefPubMedGoogle Scholar
  22. 22.
    Rondeau G, Fish S, Hann LE, et al. Ultrasonographically detected small thyroid bed nodules identified after total thyroidectomy for differentiated thyroid cancer seldom show clinically significant structural progression. Thyroid. 2011;21:845–53.CrossRefPubMedGoogle Scholar
  23. 23.
    Borget I, Corone C, Nocaudie M, et al. Sick leave for follow-up control in thyroid cancer patients: comparison between stimulation with Thyrogen and thyroid hormone withdrawal. Eur J Endocrinol. 2007;156:531–8.CrossRefPubMedGoogle Scholar
  24. 24.
    Wartofsky L. Management of low-risk well-differentiated thyroid cancer based only on thyroglobulin measurement after recombinant human thyrotropin. Thyroid. 2002;12:583–90.CrossRefPubMedGoogle Scholar
  25. 25.
    Kloos RT, Mazzaferri EL. A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90:5047–57.CrossRefPubMedGoogle Scholar
  26. 26.
    Kloos RT. Thyroid cancer recurrence in patients clinically free of disease with undetectable or very low serum thyroglobulin values. J Clin Endocrinol Metab. 2010;95:5241–8.CrossRefPubMedGoogle Scholar
  27. 27.
    Castagna MG, Brilli L, Pilli T, et al. Limited value of repeat recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSH-stimulated thyroglobulin and undetectable basal serum thyroglobulin levels. J Clin Endocrinol Metab. 2008;93:76–81.CrossRefPubMedGoogle Scholar
  28. 28.
    Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, Wartofsky L. Does an undetectable rhTSH-stimulated Tg level 12 months after initial treatment of thyroid cancer indicate remission? Clin Endocrinol (Oxf). 2011;74(1):111–7.CrossRefGoogle Scholar
  29. 29.
    Miyauchi A, Kudo T, Miya A, et al. Prognostic impact of serum thyroglobulin doubling-time under thyrotropin suppression in patients with papillary thyroid carcinoma who underwent total thyroidectomy. Thyroid. 2011;21:707–16.CrossRefPubMedGoogle Scholar
  30. 30.
    Kendall-Taylor P. Guidelines for the management of thyroid cancer. Clin Endocrinol. 2003;58:400–2.CrossRefGoogle Scholar
  31. 31.
    David A, Blotta A, Rossi R, et al. Clinical value of different responses of serum thyroglobulin to recombinant human thyrotropin in the follow-up of patients with differentiated thyroid carcinoma. Thyroid. 2005;15:267–73.CrossRefPubMedGoogle Scholar
  32. 32.
    Ain KB. Papillary thyroid carcinoma. Etiology, assessment, and therapy. Endocrinol Metab Clin N Am. 1995;24:711–60.Google Scholar
  33. 33.
    Mazzaferri EL. Long-term outcome of patients with differentiated thyroid carcinoma: effect of therapy. Endocr Pract. 2000;6:469–76.CrossRefPubMedGoogle Scholar
  34. 34.
    Hay ID. Papillary thyroid carcinoma. Endocrinol Metab Clin N Am. 1990;19:545–76.Google Scholar
  35. 35.
    Grunwald F, Schomburg A, Bender H, et al. Fluorine-18 fluorodeoxyglucose positron emission tomography in the follow-up of differentiated thyroid cancer. Eur J Nucl Med. 1996;23:312–9.CrossRefPubMedGoogle Scholar
  36. 36.
    Sisson JC, Ackermann RJ, Meyer MA, Wahl RL. Uptake of 18-fluoro2-deoxy-D-glucose by thyroid cancer: implications for diagnosis and therapy. J Clin Endocrinol Metab. 1993;77:1090–4.PubMedGoogle Scholar
  37. 37.
    Chung JK, So Y, Lee JS, et al. Value of FDG PET in papillary thyroid carcinoma with negative 131I whole-body scan. J Nucl Med. 1999;40:986–92.PubMedGoogle Scholar
  38. 38.
    Chin BB, Patel P, Cohade C, et al. Recombinant human thyrotropin stimulation of fluoro-D-glucose positron emission tomography uptake in well-differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2004;89:91–5.CrossRefPubMedGoogle Scholar
  39. 39.
    Yeo JS, Chung JK, So Y, et al. F-18-fluorodeoxyglucose positron emission tomography as a presurgical evaluation modality for I-131 scan-negative thyroid carcinoma patients with local recurrence in cervical lymph nodes. Head Neck. 2001;23:94–103.CrossRefPubMedGoogle Scholar
  40. 40.
    Wang W, Larson SM, Fazzari M, et al. Prognostic value of [18F] fluorodeoxyglucose positron emission tomographic scanning in patients with thyroid cancer. J Clin Endocrinol Metab. 2000;85:1107–13.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Endocrinology ServiceDwight David Eisenhower Army Medical CenterFt. GordonUSA
  2. 2.Endocrinology DivisionUniformed Services University of the Health Sciences, Walter Reed National Military Medical CenterBethesdaUSA

Personalised recommendations