His Upper GI Tract

Abstract

Upper gastrointestinal complaints such as heartburn, difficulty swallowing, and abdominal pain are common among men. These complaints may be due to uncomplicated disease or harbingers of more serious illness. Careful questioning and physical examination can help guide the diagnostic workup and initial treatment options. Upper endoscopy is often diagnostic and therapeutic for many disorders, but other tests may include radiography, ultrasound, pH monitoring, esophageal manometry, and gastric emptying studies. Most common upper gastrointestinal disorders can be medically managed. However, advanced endoscopic and laparoscopic procedures with low complication rates, short hospital stays, and durable results are now available for the management of refractory and complicated disease.

In this chapter, we discuss five of the common complaints and their associated diseases: heartburn and reflux, upper abdominal pain and discomfort, esophageal dysphagia, chronic nausea and vomiting, and bleeding. Using current guidelines and literature, we recommend initial diagnostic studies and therapies and review when it is appropriate to refer patients to a specialist.

Keywords

Gastroesophageal reflux disease (GERD) Dyspepsia Dysphagia Obesity Peptic ulcer disease Gallbladder disease Nausea Vomiting GI bleeding Esophageal dysmotility Cancer 

References

  1. 1.
    Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005;3(6):543–52.CrossRefPubMedGoogle Scholar
  2. 2.
    Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci. 1993;38(9):1569–80.CrossRefPubMedGoogle Scholar
  3. 3.
    Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, The Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20.CrossRefPubMedGoogle Scholar
  4. 4.
    Dent J, El-Serag HB, Wallander M-A, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2005;54(5):710–7.PubMedCentralCrossRefPubMedGoogle Scholar
  5. 5.
    Bytzer P, Jones R, Vakil N, Junghard O, Lind T, Wernersson B, et al. Limited ability of the proton-pump inhibitor test to identify patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2012;10(12):1360–6.CrossRefPubMedGoogle Scholar
  6. 6.
    Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108(3):308–29.CrossRefPubMedGoogle Scholar
  7. 7.
    Stefanidis D, Hope WW, Kohn GP, Reardon PR, Richardson WS, Fanelli RD, et al. Guidelines for surgical treatment of gastroesophageal reflux disease. Surg Endosc. 2010;24(11):2647–69.CrossRefPubMedGoogle Scholar
  8. 8.
    Scott-Conner CE. Laparoscopic Nissen Fundoplication. In: Scott-Conner CE, editor. Chassin’s operative strategy in general surgery. 4th ed. New York: Springer; 2014.CrossRefGoogle Scholar
  9. 9.
    Robinson B, Dunst CM, Cassera MA, Reavis KM, Sharata A, Swanstrom LL. 20 years later: laparoscopic fundoplication durability. Surg Endosc. 2014.Google Scholar
  10. 10.
    Frezza EE, Ikramuddin S, Gourash W, Rakitt T, Kingston A, Luketich J, et al. Symptomatic improvement in gastroesophageal reflux disease (GERD) following laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2002;16(7):1027–31.CrossRefPubMedGoogle Scholar
  11. 11.
    Perry Y, Courcoulas AP, Fernando HC, Buenaventura PO, McCaughan JS, Luketich JD. Laparoscopic Roux-en-Y gastric bypass for recalcitrant gastroesophageal reflux disease in morbidly obese patients. JSLS. 2004;8(1):19–23.PubMedCentralPubMedGoogle Scholar
  12. 12.
    Varela JE, Hinojosa MW, Nguyen NT. Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disease. Surg Obes Relat Dis. 2009;5(2):139–43.CrossRefPubMedGoogle Scholar
  13. 13.
    Talley NJ, Vakil N. The Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005;100(10):2324–37.CrossRefPubMedGoogle Scholar
  14. 14.
    Delaney BC, Qume M, Moayyedi P, Logan RFA, Ford AC, Elliott C, et al. Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial). BMJ. 2008;336(7645):651–4.PubMedCentralCrossRefPubMedGoogle Scholar
  15. 15.
    Kim KO. Normal upper GI findings and normal variants. In: Chun HJ, Yang S-K, Choi M-G, editors. Clinical gastrointestinal endoscopy. Berlin: Springer; 2014.Google Scholar
  16. 16.
    Kim SG. Early gastric cancers. In: Chun HJ, Yang S-K, Choi M-G, editors. Clinical gastrointestinal endoscopy. Berlin: Springer; 2014.Google Scholar
  17. 17.
    Gielisse EAR, Kuyvenhoven JP. Follow-up endoscopy for benign-appearing gastric ulcers has no additive value in detecting malignancy. Gastric Cancer. 2014:1–7.Google Scholar
  18. 18.
    Laine L, Hopkins R, Girardi L. Has the impact of Helicobacter pylori therapy on ulcer recurrence in the United States been overstated? A meta-analysis of rigorously designed trials. Am J Gastroenterol. 1998;93(9):1409–15.PubMedGoogle Scholar
  19. 19.
    Chey WD, Wong BCY. Practice parameters committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808–25.CrossRefPubMedGoogle Scholar
  20. 20.
    Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon ATR, Bazzoli F, et al. Management of helicobacter pylori infection--the Maastricht IV/Florence consensus report. Gut. 2012;61(5):646–64.CrossRefPubMedGoogle Scholar
  21. 21.
    Yuan Y, Padol IT, Hunt RH. Peptic ulcer disease today. Nat Clin Pract Gastroenterol Hepatol. 2006;3(2):80–9.CrossRefPubMedGoogle Scholar
  22. 22.
    Thomopoulos KC, Melachrinou MP, Mimidis KP, Katsakoulis EC, Margaritis VG, Vagianos CE, et al. Gastric ulcers and risk for cancer. Is follow-up necessary for all gastric ulcers? Int J Clin Pract. 2004;58(7):675–7.CrossRefPubMedGoogle Scholar
  23. 23.
    Hopper AN, Stephens MR, Lewis WG, Blackshaw GRJC, Morgan MA, Thompson I, et al. Relative value of repeat gastric ulcer surveillance gastroscopy in diagnosing gastric cancer. Gastric Cancer. 2006;9(3):217–22.CrossRefPubMedGoogle Scholar
  24. 24.
    Yeh JM, Ho W, Hur C. Cost-effectiveness of endoscopic surveillance of gastric ulcers to improve survival. Gastrointest Endosc. 2010;72(1):33–43.PubMedCentralCrossRefPubMedGoogle Scholar
  25. 25.
    Saini SD, Eisen G, Mattek N, Schoenfeld P. Utilization of upper endoscopy for surveillance of gastric ulcers in the united states. Am J Gastroenterol. 2008;103(8):1920–5.CrossRefPubMedGoogle Scholar
  26. 26.
    Wang YR, Richter JE, Dempsey DT. Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006. Ann Surg. 2010;251(1):51–8.CrossRefPubMedGoogle Scholar
  27. 27.
    Shaffer EA. Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006;20(6):981–96.CrossRefPubMedGoogle Scholar
  28. 28.
    Diehl AK, Sugarek NJ, Todd KH. Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis. Am J Med. 1990;89(1):29–33.CrossRefPubMedGoogle Scholar
  29. 29.
    Ransohoff DF, Gracie WA. Treatment of gallstones. Ann Intern Med. 1993;119(7 Pt 1):606–19.CrossRefPubMedGoogle Scholar
  30. 30.
    Internal Clinical Guidelines Team (UK). Gallstone Disease: Diagnosis and management of cholelithiasis, cholecystitis and choledocholithiasis. London: National Institute for Health and Care Excellence (UK); 2014.Google Scholar
  31. 31.
    Rubin RA, Kowalski TE, Khandelwal M, Malet PF. Ursodiol for hepatobiliary disorders. Ann Intern Med. 1994;121(3):207–18.CrossRefPubMedGoogle Scholar
  32. 32.
    Jazrawi RP, Pigozzi MG, Galatola G, Lanzini A, Northfield TC. Optimum bile acid treatment for rapid gall stone dissolution. Gut. 1992;33(3):381–6.PubMedCentralCrossRefPubMedGoogle Scholar
  33. 33.
    Villanova N, Bazzoli F, Taroni F, Frabboni R, Mazzella G, Festi D, et al. Gallstone recurrence after successful oral bile acid treatment. A 12-year follow-up study and evaluation of long-term postdissolution treatment. Gastroenterology. 1989;97(3):726–31.PubMedGoogle Scholar
  34. 34.
    Ros E, Navarro S, Bru C, Garcia-Puges A, Valderrama R. Occult microlithiasis in “idiopathic” acute pancreatitis: prevention of relapses by cholecystectomy or ursodeoxycholic acid therapy. Gastroenterology. 1991;101(6):1701–9.PubMedGoogle Scholar
  35. 35.
    Petroni ML, Jazrawi RP, Pazzi P, Zuin M, Lanzini A, Fracchia M, et al. Risk factors for the development of gallstone recurrence following medical dissolution. The British-Italian Gallstone Study Group. Eur J Gastroenterol Hepatol. 2000;12(6):695–700.CrossRefPubMedGoogle Scholar
  36. 36.
    Spechler SJ. AGA technical review on treatment of patients with dysphagia caused by benign disorders of the distal esophagus. Gastroenterology. 1999;117(1):233–54.CrossRefPubMedGoogle Scholar
  37. 37.
    Mahesh VN, Holloway RH, Nguyen NQ. Changing epidemiology of food bolus impaction: Is eosinophilic esophagitis to blame? J Gastroenterol Hepatol. 2013;28(6):963–6.CrossRefPubMedGoogle Scholar
  38. 38.
    Dellon ES, Liacouras CA. Advances in clinical management of eosinophilic esophagitis. Gastroenterology. 2014;147(6):1238–54.CrossRefPubMedGoogle Scholar
  39. 39.
    Smith PM, Kerr GD, Cockel R, Ross BA, Bate CM, Brown P, et al. A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture. Restore Investigator Group. Gastroenterology. 1994;107(5):1312–8.CrossRefPubMedGoogle Scholar
  40. 40.
    Rustgi AK, El-Serag HB. Esophageal carcinoma. N Engl J Med. 2014;371(26):2499–509.CrossRefPubMedGoogle Scholar
  41. 41.
    Talukdar R, Inoue H, Reddy DN. Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: a systematic review and meta-analysis. Surg Endosc. 2014:1–17.Google Scholar
  42. 42.
    Richter JE. Oesophageal motility disorders. Lancet. 2001;358(9284):823–8.CrossRefPubMedGoogle Scholar
  43. 43.
    Galmiche JP, Clouse RE, Bálint A, Cook IJ, Kahrilas PJ, Paterson WG, et al. Functional esophageal disorders. Gastroenterology. 2006;130(5):1459–65.CrossRefPubMedGoogle Scholar
  44. 44.
    American Gastroenterological Association medical position statement. Nausea and vomiting. Gastroenterology. 2001;120(1):261–2.CrossRefGoogle Scholar
  45. 45.
    Scorza K, Williams A, Phillips JD, Shaw J. Evaluation of nausea and vomiting. Am Fam Physician. 2007;76(1):76–84.PubMedGoogle Scholar
  46. 46.
    Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L. American College of Gastroenterology. Clinical guideline: management of gastroparesis. Am J Gastroenterol. 2013;108(1):18–37.PubMedCentralCrossRefPubMedGoogle Scholar
  47. 47.
    Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, et al. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011;140(1):101–15.CrossRefPubMedGoogle Scholar
  48. 48.
    Quigley EM. Other forms of gastroparesis: postsurgical, Parkinson, other neurologic diseases, connective tissue disorders. Gastroenterol Clin North Am. 2015;44(1):69–81.CrossRefPubMedGoogle Scholar
  49. 49.
    Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Melton LJ, Talley NJ. Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. Am J Gastroenterol. 2012;107(1):82–8.PubMedCentralCrossRefPubMedGoogle Scholar
  50. 50.
    Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am J Gastroenterol. 2008;103(3):753–63.CrossRefPubMedGoogle Scholar
  51. 51.
    Chu H, Lin Z, Zhong L, McCallum RW, Hou X. Treatment of high-frequency gastric electrical stimulation for gastroparesis. J Gastroenterol Hepatol. 2012;27(6):1017–26.CrossRefPubMedGoogle Scholar
  52. 52.
    Enestvedt BK, Gralnek IM, Mattek N, Lieberman DA, Eisen G. An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium. Gastrointest Endosc. 2008;67(3):422–9.CrossRefPubMedGoogle Scholar
  53. 53.
    Richards RJ, Donica MB, Grayer D. Can the blood urea nitrogen/creatinine ratio distinguish upper from lower gastrointestinal bleeding? J Clin Gastroenterol. 1990;12(5):500–4.CrossRefPubMedGoogle Scholar
  54. 54.
    Huang ES, Karsan S, Kanwal F, Singh I, Makhani M, Spiegel BM. Impact of nasogastric lavage on outcomes in acute GI bleeding. Gastrointest Endosc. 2011;74(5):971–80.CrossRefPubMedGoogle Scholar
  55. 55.
    Raju GS, Gerson L, Das A, Lewis B. American Gastroenterological Association (AGA) Institute technical review on obscure gastrointestinal bleeding. Gastroenterology. 2007;133(5):1697–717.CrossRefPubMedGoogle Scholar
  56. 56.
    Lewis BS, Eisen GM, Friedman S. A pooled analysis to evaluate results of capsule endoscopy trials. Endoscopy. 2005;37(10):960–5.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of SurgeryStanford University School of MedicineStanfordUSA
  2. 2.Stanford University School of MedicineStanfordUSA

Personalised recommendations