Oxygen Transport to Tissue XXXVII pp 501-509 | Cite as
A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS
Abstract
We present a new framework for the assessment of cerebral hemodynamics regulation (CHR) in neonates using near-infrared spectroscopy (NIRS). In premature infants, NIRS measurements have been used as surrogate variables for cerebral blood flow (CBF) in the assessment of cerebral autoregulation (CA). However, NIRS measurements only reflect changes in CBF under constant changes in arterial oxygen saturation (SaO2). This condition is unlikely to be met at the bedside in the NICU. Additionally, CA is just one of the different highly coupled mechanisms that regulate brain hemodynamics. Traditional methods for the assessment of CA do not take into account the multivariate nature of CHR, producing inconclusive results. In this study we propose a newly developed multivariate methodology for the assessment of CHR. This method is able to effectively decouple the influences of SaO2 from the NIRS measurements, and at the same time, produces scores indicating the strength of the coupling between the systemic variables and NIRS recordings. We explore the use of this method, and its derived scores, for the monitoring of CHR using data from premature infants who developed a grade III-IV intra-ventricular hemorrhage during the first 3 days of life.
Keywords
Cerebral autoregulation NIRS Multivariable Premature infantsNotes
Acknowledgments
Research supported by the Research foundation Flanders (FWO); Research Council KUL: GOA MaNet, CoE PFV/10/002 (OPTEC). Flemish Government: FWO: travel grant. Belgian Federal Science Policy Office: IUAP P719/(DYSCO), ‘Dynamical systems, control and optimization’, 2012–2017. Belgian Federal Science Policy Office: IUAP P7/19 DYSCO. EU HIP Trial FP7-HEALTH/2007–2013 (n° 260777).
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