Neurovascular Interactions in the Neurologically Compromised Neonatal Brain
Neurological brain injuries such as hypoxic ischaemic encephalopathy (HIE) and associated conditions such as seizures have been associated with poor developmental outcome in neonates. Our limited knowledge of the neurological and cerebrovascular processes underlying seizures limits their diagnosis and timely treatment. Diffuse optical tomography (DOT) provides haemodynamic information in the form of changes in concentration of de/oxygenated haemoglobin, which can improve our understanding of seizures and the relationship between neural and vascular processes. Using simultaneous EEG-DOT, we observed distinct haemodynamic changes which are temporally correlated with electrographic seizures. Here, we present DOT-EEG data from two neonates clinically diagnosed as HIE. Our results highlight the wealth of mutually-informative data that can be obtained using DOT-EEG techniques to understand neurovascular coupling in HIE neonates.
KeywordsNeurovascular coupling Diffuse optical tomography Neonatal seizures Burst suppression Hypoxic–ischaemic encephalopathy
The authors are thankful to the parents and staff on the Neonatal Intensive Care Unit at the Rosie Hospital, Cambridge, UK; funders Action Medical Research (AMR-1945) and EPSRC (EP/J021318/1).
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