Molecular Basis of Breast Cancer Imaging

  • Gopal R. Vijayaraghavan
  • Srinivasan Vedantham
  • Ashraf Khan
  • Andrew Karellas
Chapter
First Online:
Part of the Molecular Pathology Library book series (MPLB, volume 10)

Abstract

Over the past decade, annually for women 50 years of age or older, the breast cancer incidence rate in the United States has ranged from 400 to 500 per 100 000 women and the breast cancer mortality rate has ranged from 60 to 80 per 100 000 women. Though there has been a decline in the breast cancer mortality in the past decade it continues to be the second leading cause of death after lung cancer in women over 40 years of age. Breast cancer continues to be a major health issue among women in the United States. Screening mammogram has significantly contributed to the reduction in mortality. However, screening mammogram has its own limitations. Its sensitivity is 80 % in fatty breasts but is substantially lower in dense breasts. On average nearly 30 % of women reporting for mammograms have dense breasts and 1 in 2 cancers in dense breasts are missed on mammograms due to the masking effect caused by overlapping tissues.

Keywords

Molecular basis Breast cancer Imaging Screening techniques 
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References

  1. 1.
    DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clinic. 2014;64(1):52–62.CrossRefGoogle Scholar
  2. 2.
    Mandelson MT, Oestreicher N, Porter PL, White D, Finder CA, Taplin SH, White E. Breast density as a predictor of mammographic detection: comparison of interval and screen detected cancers. J Natl Cancer Inst. 2000;92(13):1081–7.CrossRefPubMedGoogle Scholar
  3. 3.
    Drukteinis JS, Mooney BP, Floers CI, Gatenby RA. Beyond mammography: new frontiers in breast cancer screening. American J Med. 2013;126(6):472–9.CrossRefGoogle Scholar
  4. 4.
    Niklason LT, Christian BT, Niklason LE, Kopans DB, Castleberry DE, OpsahlOng BH, Landberg CE, Slanetz PJ, Giardino AA, Moore R, Albagli D, DeJule MC, Fitzgerald PF, Fobare DF, Giambattista BW, Kwasnick RF, Liu JQ, Lubowski SJ, Possin GE, Richotte JF, Wei CY, Wirth RF. Digital tomosynthesis in breast imaging. Radiology. 1997;205(2):399–406.CrossRefPubMedGoogle Scholar
  5. 5.
    Herranz M, Ruibal A. Optical imaging in breast cancer diagnosis: the next evolution. J Oncol. 2012;2012:863747.PubMedCentralCrossRefPubMedGoogle Scholar
  6. 6.
    Hruska CB, O’Connor MK. Nuclear imaging of the breast: translating achievements in instrumentation into clinical use. Med Phys. 2013;40(5):050901–23.PubMedCentralCrossRefPubMedGoogle Scholar
  7. 7.
    Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O’Connor MK. Dedicated dual-head gamma imaging for breast cancer screening in women with mammographically dense breasts. Radiology. 2011;258(1):106–18.CrossRefPubMedGoogle Scholar
  8. 8.
    Weigert JM, Bertrand ML, Lanzkowsky L, Stern LH, Kieper DA. Results of a multicenter patient registry to determine the clinic impact of breast specific gamma imaging, a molecular breast imaging technique. AJR. 2012;198:W69–75.CrossRefPubMedGoogle Scholar
  9. 9.
    O’Connor MK, Philips SW, Hruska CB, Rhodes DJ, Collins DA. Molecular breast imaging: advantages and limitations of a scintimammographic technique in patients with small breast tumors. Breast J. 2007;13(1):3–11.CrossRefPubMedGoogle Scholar
  10. 10.
    Hendrick RE. Radiation doses and cancer risks from breast imaging studies. Radiology. 2010;257(1):246–53.CrossRefPubMedGoogle Scholar
  11. 11.
    Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA. Twenty five year follow up for breast cancer incidence and mortality of the Canadian national breast screening study: randomized screening trail. BMJ. 2014;348:g366.PubMedCentralCrossRefPubMedGoogle Scholar
  12. 12.
    Checka CM, Chun JE, Schnabel FR, Lee J, Toth H. The relationship of mammographic density and age: implications for breast cancer screening. AJR. 2012;198:W292–5.CrossRefPubMedGoogle Scholar
  13. 13.
    Buist DS, Porter PL, Lehman C, Taplin SH, White E. Factors contributing to mammography failure in women aged 40–49 years. J Natl Cancer Inst. 2004;96(19):1432–40.CrossRefPubMedGoogle Scholar
  14. 14.
    Ciatto S, Houssami N, Bernardi D, Caumo F, Pellegrini M, Brunelli S, Tuttobene P, Bricolo P, Fanto C, Valentini M, Montemezzi S, Macaskill P. Integration of 3D digital mammography with tomosynthesis for population breast-cancer screening (STORM): a prospective comparison study. Lancet Oncol. 2013;14(7):583–9.CrossRefPubMedGoogle Scholar
  15. 15.
    Giuliano V, Giuliano C. Improved breast cancer detection in asymptomatic women using 3D-automated breast ultrasound in mammographically dense breasts. Clin Imaging. 2013;37(3):480–6.CrossRefPubMedGoogle Scholar
  16. 16.
    Hruska CB, Phillips SW, Whaley DH, Rhodes DJ, O’Connor MK. Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors. AJR. 2008;191:1805–15.CrossRefPubMedGoogle Scholar
  17. 17.
    Brem RF, Rapelyea JA, Zisman G, Mohtashemi K, Raub J, Teal CB, Majewski S, Welch BL. Occult breast cancer: scintimammography with high-resolution breast-specific gamma camera in women at high risk for breast cancer. Radiology. 2005;237:274–80.CrossRefPubMedGoogle Scholar
  18. 18.
    Brem RF, Floerke AC, Rapelyea JA, Teal C, Kelly T, Mathur V. Breast specific gamma imaging as an adjunct imaging modality for the diagnosis of breast cancer. Radiology. 2008;247:651–7.CrossRefPubMedGoogle Scholar
  19. 19.
    Kalles V, Zografos GC, Provatopoulou X, Koulocheri D, Gounaris A. The current status of positron emission mammography in breast cancer diagnosis. Breast Cancer. 2013;20:123–30.CrossRefPubMedGoogle Scholar
  20. 20.
    Narayanan D, Madsen KS, Kalinyak JE, Berg WA. Interpretation of positron emission mammograpghy and MRI by experienced breast imaging radiologists: performance and observer reproducibility. AJR. 2011;196:971–81.PubMedCentralCrossRefPubMedGoogle Scholar
  21. 21.
    Kalinyak JE, Schilling K, Berg WA, Narayanan D, Mayberry JP, Rai R, Dupree EB, Shusterman DK, Gittleman MA, Luo W, Matthews CG. PET guided breast biopsy. Breast J. 2011;17(2):143–51.CrossRefPubMedGoogle Scholar
  22. 22.
    Berg WA, Madsen KS, Schilling K, Tartar M, Pisano EA, Larsen LH, Narayanan D, Ozonoff A, Miller JP, Kalinyak JE. Breast cancer: comparative effectiveness of positron emission mammography and MR imaging in presurgical planning for the ipsilateral breast. Radiology. 2011;258:59–72.PubMedCentralCrossRefPubMedGoogle Scholar
  23. 23.
    Berg WA, Madsen KS, Schilling K, Tartar M, Pisano ED, Larsen LH, Narayanan D, Kalinyak JE. Comparative effectiveness of positron emission mammography and MRI in the contralateral breast of women with newly diagnosed breast cancer. AJR. 2012;198:219–32.CrossRefPubMedGoogle Scholar
  24. 24.
    Centers for Disease. C. Inappropriate use of transillumination for breast cancer screening–Wisconsin, 1990. MMWR. Morb Mortal Wkly Rep. 1991;40(18):293–6.Google Scholar
  25. 25.
    Shah N, Cerussi A, Eker C, Espinoza J, Butler J, Fishkin J, Hornung R, Tromberg BJ. Noninvasive functional optical spectroscopy of human breast tissue. Proc Nat Acad Sci. 2001;98(8):4420–5.PubMedCentralCrossRefPubMedGoogle Scholar
  26. 26.
    Gonzalez J, Decerce J, Erickson SJ, Martinez SL, Nunez A, Roman M, Traub B, Flores CA, Roberts SM, Hernandez E, Aguirre W, Kiszonas R, Godavarty A. Hand-held optical imager (Gen-2): improved instrumentation and target detectability. J Biomed Opt. 2012;17(8):081402–1.PubMedCentralCrossRefPubMedGoogle Scholar
  27. 27.
    McBride TO, Pogue BW, Jiang S, Osterberg UL, Paulsen KD. A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the breast in vivo. Rev Sci Instrum. 2001;72(3):1817–24.CrossRefGoogle Scholar
  28. 28.
    Culver JP, Choe R, Holboke MJ, Zubkov L, Durduran T, Slemp A, Ntziachristos V, Chance B, Yodh AG. Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. Med Phys. 2003;30(2):235–47.CrossRefPubMedGoogle Scholar
  29. 29.
    Poplack SP, Tosteson TD, Wells WA, Pogue BW, Meaney PM, Hartov A, Kogel CA, Soho SK, Gibson JJ, Paulsen KD. Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms. Radiology. 2007;243(2):350–9.CrossRefPubMedGoogle Scholar
  30. 30.
    Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol. 2007;52(12):3619–41.CrossRefPubMedGoogle Scholar
  31. 31.
    Krishnaswamy V, Michaelsen KE, Pogue BW, Poplack SP, Shaw I, Defrietas K, Brooks K, Paulsen KD. A digital x-ray tomosynthesis coupled near infrared spectral tomography system for dual-modality breast imaging. Opt Express. 2012;20(17):19125–36.PubMedCentralCrossRefPubMedGoogle Scholar
  32. 32.
    Vedantham S, Shi L, Karellas A, Michaelsen KE, Krishnaswamy V, Pogue BW, Paulsen KD. Semi-automated segmentation and classification of digital breast tomosynthesis reconstructed images. In: Conference Proceeding of IEEE Engineering in Medicine and Biology Society, EMBC, 2011. p. 6188–6191.Google Scholar
  33. 33.
    Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology. 2011;258(1):89–97.PubMedCentralCrossRefPubMedGoogle Scholar
  34. 34.
    Zhu Q, Cronin EB, Currier AA, Vine HS, Huang M, Chen N, Xu C. Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction. Radiology. 2005;237(1):57–66.PubMedCentralCrossRefPubMedGoogle Scholar
  35. 35.
    Ntziachristos V, Yodh AG, Schnall MD, Chance B. MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. Neoplasia. 2002;4(4):347–54.PubMedCentralCrossRefPubMedGoogle Scholar
  36. 36.
    Brooksby B, Jiang S, Dehghani H, Pogue BW, Paulsen KD, Kogel C, Doyley M, Weaver JB, Poplack SP. Magnetic resonance-guided near-infrared tomography of the breast. Rev Sci Instrum. 2004;75(12):5262–70.CrossRefGoogle Scholar
  37. 37.
    O’Sullivan TD, Leproux A, Chen JH, Bahri S, Matlock A, Roblyer D, McLaren CE, Chen WP, Cerussi AE, Su MY, Tromberg BJ. Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy. Breast Cancer Res. 2013;15(1):R14.PubMedCentralCrossRefPubMedGoogle Scholar
  38. 38.
    Laughney AM, Krishnaswamy V, Rice TB, Cuccia DJ, Barth RJ, Tromberg BJ, Paulsen KD, Pogue BW, Wells WA. System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues. J Biomed Opt. 2013;18(3):036012.PubMedCentralCrossRefPubMedGoogle Scholar
  39. 39.
    Dhar S, Lo JY, Palmer GM, Brooke MA, Nichols BS, Yu B, Ramanujam N, Jokerst NM. A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays. Biomedical optics express. 2012;3(12):3211–22.PubMedCentralCrossRefPubMedGoogle Scholar
  40. 40.
    Jacobs L. Positive margins: the challenge continues for breast surgeons. Ann Surg Oncol. 2008;15(5):1271–2.PubMedCentralCrossRefPubMedGoogle Scholar
  41. 41.
    Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Multimodal optical imaging for detecting breast cancer. J Biomed Optics. 2012;17(6):066008.CrossRefGoogle Scholar
  42. 42.
    Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography. Biophoton. 2013;6(9):679–86.CrossRefGoogle Scholar
  43. 43.
    Patel R, Khan A, Quinlan R, Yaroslavsky AN. Polarization sensitive multimodal imaging for detecting breast cancer. Cancer Res. 2014;74(17):4685–93.CrossRefPubMedGoogle Scholar
  44. 44.
    Azu M, Abrahamse P, Katz SJ, Jagsi R, Morrow M. What is an adequate margin for breast-conserving surgery? Surgeon attitudes and correlates. Ann Surg Oncol. 2010;17:558–63.PubMedCentralCrossRefPubMedGoogle Scholar
  45. 45.
    Backman V, Wallace MB, Perelman LT, Arendt JT, Gurjar R, Müller MG, Zhang Q, Zonios G, Kline E, McGilligan JA, Shapshay S, Valdez T, Badizadegan K, Crawford JM, Fitzmaurice M, Kabani S, Levin HS, Seiler M, Dasari RR, Itzkan I, Van Dam J, Feld MS. Nature. 2000;406(6791):35–6.CrossRefPubMedGoogle Scholar
  46. 46.
    Brown JQ, Vishwanath K, Palmer GM, Ramanujam N. Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer. Curr Opin Biotechnol. 2009;20(1):119–31.PubMedCentralCrossRefPubMedGoogle Scholar
  47. 47.
    Brown JQ, Bydlon TM, Kennedy SA, Caldwell ML, Gallagher JE, Junker M, Wilke LG, Barry WT, Geradts J, Ramanujam N. Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins. PLoS ONE. 2013;8(7):e69906.PubMedCentralCrossRefPubMedGoogle Scholar
  48. 48.
    Fitzgerald AJ, Wallace VP, Jimenez-Linan M, Bobrow L, Pye RJ, Purushotham AD, Arnone DD. Terahertz pulsed imaging of human breast tumors. Radiology. 2006;239(2):533–40.CrossRefPubMedGoogle Scholar
  49. 49.
    Fitzgerald AJ, Pinder S, Purushotham AD, O’Kelly P, Ashworth PC, Wallace VP. Classification of terahertz-pulsed imaging data from excised breast tissue. J Biomed Opt. 2012;17(1):016005.CrossRefPubMedGoogle Scholar
  50. 50.
    Fitzgerald AJ, Pickwell-MacPherson E, Wallace VP. Use of finite difference time domain simulations and debye theory for modelling the terahertz reflection response of normal and tumour breast tissue. PLoS ONE. 2014;9(7):e99291.PubMedCentralCrossRefPubMedGoogle Scholar
  51. 51.
    Yngvesson SK, St Peter B, Siqueira P, Kelly P, Glick S, Karellas A, Khan A. Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination. In: Proceedings of society of photo-optical instrumentation engineers 2012. Optical interactions with tissue and cells XXIII; vol. 8221, 82210N.Google Scholar
  52. 52.
    St Peter B, Yngvesson S, Siqueira P, Kelly P, Khan A, Glick S, Karellas A. Development and testing of a single frequency terahertz imaging system for breast cancer detection. IEEE J Biomed Health Inform. 2013;17(4):785–797.Google Scholar
  53. 53.
    Ajito K, Ueno Y. Thz chemical imaging for biological applications. IEEE Trans Thz Sci Techn. 2011;1(1):293–300.CrossRefGoogle Scholar
  54. 54.
    Ashworth PC, Pickwell-MacPherson E, Provenzano E, Pinder SE, Purushotham AD, Pepper M, Wallace VP. Terahertz pulsed spectroscopy of freshly excised human breast cancer. Opt Express. 2009;17(15):12444–54.CrossRefPubMedGoogle Scholar
  55. 55.
    Savastru D, Chang EW, Miclos S, Pitman MB, Patel A, Iftimia N. Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study. J Biomed Opt. 2014;19(5):056001.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Gopal R. Vijayaraghavan
    • 2
  • Srinivasan Vedantham
    • 2
  • Ashraf Khan
    • 1
  • Andrew Karellas
    • 2
  1. 1.Department of PathologyUniversity of Massachusetts Medical School, UMassMemorial Medical CenterWorcesterUSA
  2. 2.Department of RadiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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