Radiation-Induced Lumbosacral Plexopathy
Radiation for pelvic malignancies can adversely affect nearby structures in the nervous system including the lumbosacral plexus. Radiation-induced lumbosacral plexopathy (RILSP) is the most commonly reported neurologic complication of pelvic radiation. There are no established predictive models for the development of RILSP, which often presents with distal lower extremity weakness followed by lower extremity sensory loss. Direct tumor involvement of plexus is more common than RILSP and is the most important differential consideration. Besides the history and neurologic examination, magnetic resonance imaging (MRI) and electromyography (EMG) are the most important diagnostic tools. RILSP causes significant neurologic morbidity. In most cases, there is very slow recovery of neurologic function over years. There is no effective treatment to date.
KeywordsRadiation Fibrosis Lumbosacral Plexopathy Pelvic Gynecologic Malignancy
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