Mathematical Models for Topical and Transdermal Drug Products

  • Yuri G. Anissimov
  • Michael S. Roberts


Mathematical models of epidermal and dermal transport, which includes transport of a solute through vehicle and various layers of the skin, metabolism in the skin and its subsequent distribution and clearance into systemic circulation from underlying tissues, play an essential role in development of topical and transdermal drug products and are reviewed in this chapter.


Percutaneous drug delivery Mathematical modelling 



We thank the NH&MRC of Australia PAH Research Foundation and the NSW and Qld Lions Medical Research Foundation for the support of this work.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Queensland Micro- and Nanotechnology CentreGriffith UniversityBrisbaneAustralia
  2. 2.School of Biomolecular and Physical SciencesGriffith UniversityGold CoastAustralia
  3. 3.Therapeutics Research Unit, School of MedicineThe University of Queensland, Princess Alexandra HospitalWoolloongabbaAustralia
  4. 4.School of Pharmacy & Medical SciencesUniversity of South AustraliaAdelaideAustralia

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