A Review of Available Software and Capabilities for Adaptive Designs
This chapter provides a brief review of methodologies and software solutions for several types of adaptive designs: the traditional and adaptive group sequential designs including sample size reestimation, multistage adaptive designs with arm and subpopulation selection at interim analyses, and adaptive designs for dose-finding studies.
KeywordsAdaptive design software Simulations Group sequential Many-to-one comparison Arm selection Population enrichment Dose-ranging
The author would like to thank Steve Ascher for his help with writing this chapter.
- Bauer P (1989) Multistage testing with adaptive designs. Biom Inform Med Biol 20:130–148Google Scholar
- Bauer P, Brannath W, Posch M (2001) Flexible two stage designs: an overview. Methods Inf Med 40:117–121Google Scholar
- Bornkamp B, Bretz F, Dmitrienko A, Enas G, Gaydos B, Hsu CH, Koenig F, Krams M, Liu Q, Neuenschwander B, Parke T, Pinheiro J, Roy A, Sax R, Shen F (2007) Innovative approaches for designing and analyzing adaptive dose-ranging trials (with discussion). J Biopharm Stat 17:965–995CrossRefGoogle Scholar
- Bornkamp B, Pinheiro JC, Bretz F (2009) MCPMod: an R package for the design and analysis of dose-finding studies. J Stat Software 29(7):1–23Google Scholar