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Regulation of Excitatory Synapses by Stress Hormones

  • Marian Joëls
  • Harm Krugers
  • Henk Karst
Chapter

Abstract

Shortly after stress, brain levels of many transmitters and hormones such as corticosterone are elevated. In the brain, corticosterone affects those cells that express high-affinity mineralocorticoid receptors (MRs) and/or lower-affinity glucocorticoid receptors (GRs). Principal neurons in the hippocampal cornus ammoni 1 (CA1) area and dentate gyrus abundantly express both MR and GR, while principal cells in the basolateral amygdala have high GR but relatively low MR levels. Neurons in all three areas quickly respond to corticosterone with an enhancement in spontaneous glutamatergic transmission, an effect that is nongenomic and involves MR. This rapid effect is transient in hippocampal cells but sustained in amygdala neurons. The areas differ in their slow gene-mediated response to corticosterone. Hippocampal CA1 cells show an increased current amplitude in response to spontaneously released glutamate-containing vesicles; synaptically evoked responses are generally unaffected. The number of action potentials during a period of depolarization is attenuated, via a slow GR-dependent pathway. By contrast, basolateral amygdala neurons show higher excitability and more efficient transfer of action potentials several hours after corticosteroid exposure. The dichotomy between the two areas could explain why emotional aspects of stressful events are generally better retained than neutral aspects.

Keywords

Corticosterone Hippocampus Basolateral amygdala Stress Glucocorticoid receptor Mineralocorticoid receptor Nongenomic Glutamate Electrophysiology Hippocampus Basolateral amygdala 

Abbreviations

AHP

Afterhyperpolarization

AMPA

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

BLA

Basolateral amygdala

BSA

Bovine serum albumin

CA1

Cornus ammoni 1

(m)EPSC/EPSP

(Miniature) Excitatory postsynaptic current/potential

ERK

Extracellular signal-regulated kinase

GR

Glucocorticoid receptor

LTD

Long-term depression

LTP

Long-term potentiation

MEK

Mitogen-activated protein kinase kinase

MR

Mineralocorticoid receptor

NMDA

N-methyl-D-aspartate

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Translational Neuroscience, Brain Center Rudolf MagnusUniversity Medical CenterUtrechtThe Netherlands
  2. 2.Swammerdam Institute for Life Sciences—Center for NeuroscienceUniversity of AmsterdamAmsterdamThe Netherlands

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