Microbiota-Gut-Brain Axis and Cognitive Function

  • Mélanie G. GareauEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 817)


Recent studies have demonstrated a clear association between changes in the microbiota and cognitive behavior. Intestinal dysbiosis, as modeled using GF mice (containing no microbiota), bacterial infection with an enteric pathogen, and administration of probiotics, can modulate cognitive behavior including learning and memory. This chapter will highlight recent findings in both human and animal studies indicating how changes in the composition and diversity of the microbiota can impact behavior and brain physiology in both disease states and in health. Cognitive behavior can not only be affected in cases of intestinal disease, but also manifests changes in extra-intestinal disease conditions.


Inflammatory Bowel Disease Irritable Bowel Syndrome Hepatic Encephalopathy Intestinal Microbiota Maternal Separation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





Autonomic nervous system


Brain derived neurotropic factor


Crohn’s disease


cAMP response element binding protein


Corticotrophin-releasing factor




Dorsolateral pre-frontal cortex


Excitatory postsynaptic potential






Hepatic encephalopathy




Inflammatory bowel disease


Irritable bowel syndrome




Maternal separation


Nerve growth factor


pathogen associated molecular patterns




Specific pathogen free


Ulcerative colitis


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Copyright information

© Springer New York 2014

Authors and Affiliations

  1. 1.Department of MedicineUniversity of California, San DiegoLa JollaUSA

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