Multicentric Castleman Disease

  • Mark N. Polizzotto
  • Thomas S. Uldrick
  • Robert Yarchoan


Multicentric Castleman disease is a systemic disorder of lymph nodes characterized by inflammatory symptoms including fever, night sweats, cachexia, malaise, and lymphadenopathy together with laboratory abnormalities including anemia and hypoalbuminemia. These symptoms may be life-threatening. The diagnosis is based on specific pathological findings in affected lymph nodes. In individuals infected with HIV, multicentric Castleman disease is almost exclusively caused by infection with a cancer-causing herpesvirus, Kaposi sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8). This may be considered a separate entity from the non-KSHV related or idiopathic form of multicentric Castleman disease and from unicentric forms of Castleman disease. While these disorders have pathological and clinical similarities, the KSHV-related form is distinguished by its pathological characteristics and unique viral etiology.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Mark N. Polizzotto
    • 1
  • Thomas S. Uldrick
    • 1
  • Robert Yarchoan
    • 2
  1. 1.HIV and AIDS Malignancy BranchNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.HIV and AIDS Malignancy Branch and office of HIV and AIDS Malignancy, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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