From Detection to Rupture: A Serial Computational Fluid Dynamics Case Study of a Rapidly Expanding, Patient-Specific, Ruptured Abdominal Aortic Aneurysm

  • Barry J. Doyle
  • Timothy M. McGloughlin
  • Eamon G. Kavanagh
  • Peter R. Hoskins
Conference paper


Computational hemodynamic studies of abdominal aortic aneurysm (AAA) can help elucidate the mechanisms responsible for growth and development. The aim of this work is to determine if AAAs expand and develop intraluminal thrombus (ILT) in regions of low wall shear stress (WSS) predicted with computational fluid dynamics (CFD). Computed tomography (CT) data of an AAA was acquired at four time-points over 2.5 years, from the time of detection to immediately prior to rupture. We used 3D unsteady, laminar, CFD models to investigate the hemodynamics at each time-point. Our three-dimensional reconstructions showed that the primary region of expansion was in the proximal lobe, which not only coincided with the main region of low time-averaged WSS (TAWSS) in our CFD simulations, but also with the development of ILT in vivo. Interestingly, this region was also the rupture location. This is the first serial computational study of an AAA and the work has shown the potential of CFD to model the changing hemodynamics and the relation with ILT development and AAA growth.


Computational Fluid Dynamic Wall Shear Stress Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm Particle Residence Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We would like to thank: Stephen Broderick, Gráinne Carroll, and Adrian Lynch, University of Limerick, Ireland, for their very useful insights into CFD; David Molony, Georgia Institute of Technology, USA, for his assistance with the TAWSS post-processing; Pierce Grace, University Hospital Limerick, Ireland; and Pankaj Pankaj, The University of Edinburgh, UK.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Barry J. Doyle
    • 1
    • 2
  • Timothy M. McGloughlin
    • 3
    • 4
  • Eamon G. Kavanagh
    • 5
  • Peter R. Hoskins
    • 2
    • 6
  1. 1.Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical EngineeringThe University of Western AustraliaCrawley, PerthAustralia
  2. 2.Centre for Cardiovascular ScienceThe University of EdinburghEdinburghUK
  3. 3.Centre for Applied Biomedical Engineering Research (CABER), Department of Mechanical, Aeronautical and Biomedical Engineering, and Materials and Surface Science InstituteUniversity of LimerickLimerickIreland
  4. 4.Department of Biomedical EngineeringKhalifa University of Science, Technology & Research (KUSTAR)Abu DhabiUAE
  5. 5.Department of Vascular SurgeryUniversity Hospital LimerickLimerickIreland
  6. 6.Department of Mechanical, Aeronautical and Biomedical EngineeringUniversity of LimerickLimerickIreland

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