The Possible Role of Iron in Neurodegeneration
Iron may play deleterious role in neurodegeneration by triggering oxidative stress via Fenton reaction. Iron was studied in Parkinson’s disease (PD) with controversial results. In other neurodegenerations, e.g., Alzheimer disease (AD) and progressive supranuclear palsy (PSP), it still needs evaluation. We present the results of our long lasting studies aimed to assess the concentrations of total and labile iron and ferritin in PD, AD, and PSP. Samples of substantia nigra (SN), globus pallidus (GP), and hippocampal cortex (Hip) from PD, AD, and PSP brains were assessed with ELISA, Mössbauer spectroscopy, and atomic absorption.
Results: No increase in the concentration of total iron in PD SN vs. control was detected; however, there was an increase of labile iron, which constitutes only 1 ‰ of total iron in SN. A significant decrease of the concentration of L chains of ferritin in PD SN compared to control was found. In AD, a significant increase of the concentration of H and L ferritin was noticed, without significant increase of the iron concentration. In PSP, an increase of total iron was observed.
Conclusion: The mechanisms leading to nervous cells death in these three diseases may be different, although all may be related to iron-mediated oxidative stress
KeywordsSubstantia Nigra Progressive Supranuclear Palsy Globus Pallidus Progressive Supranuclear Palsy Iron Core
Enzyme-linked immunosorbent assay
Reactive oxygen species
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