Arthritis That Develops After Joint Injury: Is It Post-Traumatic Arthritis or Post-Traumatic Osteoarthritis?

Chapter

Abstract

Arthritis that develops after joint injury, or post-traumatic arthritis (PTA), is increasingly recognized as an important contributor to the overall burden of arthritis. PTA is in many ways ideal for the study of development of arthritis. PTA has known joint involvement and time of onset; the onset of significant arthritis is often much more rapid than nontraumatic forms of osteoarthritis. However, PTA as a disease is relatively understudied compared to rheumatoid arthritis and nontraumatic osteoarthritis. Arthritis that develops following joint injury encompasses a variety of clinical conditions, some that are similar to osteoarthritis and others that have a more distinct inflammatory phase. We believe that the terms PTA and post-traumatic osteoarthritis (PTOA) are both valid in describing the clinical condition of arthritis that develops following joint injury.

Keywords

Post-traumatic arthritis Post-traumatic osteoarthritis Joint injury Inflammation Articular injury Articular fracture 
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Notes

Acknowledgments

Supported in part by the Arthritis Foundation, Department of Defense, and NIH grant AR50245.

References

  1. 1.
    CDC. Arthritis: the nation’s most common cause of disability. Chronic disease at a glance reports: arthritis 2011 February 18, 2011 [cited 2011 October 29]; Description of demographics of the burden of disease for arthritis in the United States. Available from: http://www.cdc.gov/chronicdisease/resources/publications/aag/arthritis.htm#chart1.
  2. 2.
    Brown TD, et al. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006;20(10):739–44.PubMedCrossRefGoogle Scholar
  3. 3.
    Key JA. Experimental arthritis: the changes in joints produced by creating defects in the articular cartilage. J Bone Joint Surg Am. 1931;13(4):725–39.Google Scholar
  4. 4.
    Campbell CJ. The healing of cartilage defects. Clin Orthop Relat Res. 1969;64:45–63.PubMedGoogle Scholar
  5. 5.
    Moskowitz RW, et al. Cartilage proteoglycan alterations in an experimentally induced model of rabbit osteoarthritis. Arthritis Rheum. 1979;22(2):155–63.PubMedCrossRefGoogle Scholar
  6. 6.
    Pond MJ, Nuki G. Experimentally-induced osteoarthritis in the dog. Ann Rheum Dis. 1973;32(4):387–8.PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Repo RU, Finlay JB. Survival of articular cartilage after controlled impact. J Bone Joint Surg Am. 1977;59(8):1068–76.PubMedGoogle Scholar
  8. 8.
    Donohue JM, et al. The effects of indirect blunt trauma on adult canine articular cartilage. J Bone Joint Surg Am. 1983;65(7):948–57.PubMedGoogle Scholar
  9. 9.
    Olson SA, Guilak F. From articular fracture to posttraumatic arthritis: a black box that needs to be opened. J Orthop Trauma. 2006;20(10):661–2.PubMedCrossRefGoogle Scholar
  10. 10.
    Imboden JB, Hellman DB, Stone JH, editors. Current diagnosis and treatment of rheumatology. 3rd ed. New York, NY: McGraw-Hill; 2013. p. 578.Google Scholar
  11. 11.
    Guilak F, et al. The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res. 2004;423:17–26.PubMedCrossRefGoogle Scholar
  12. 12.
    Furman BD, et al. Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. J Orthop Res. 2007;25(5):578–92.PubMedCrossRefGoogle Scholar
  13. 13.
    Ward BD, et al. Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. Arthritis Rheum. 2008;58(3):744–53.PubMedCrossRefGoogle Scholar
  14. 14.
    Furman BD, Mangiapani DS, Zeiter E, Bailey KN, Horne PH, Huebner JL, Kraus VB, Guilak F, Olson SA. Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. Arthritis Res Ther. 2014;16:R134.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Jang KW, Buckwalter JA, Martin JA. Inhibition of cell-matrix adhesions prevents cartilage chondrocyte death following impact injury. J Orthop Res. 2014;32(3):448–54.PubMedCentralPubMedCrossRefGoogle Scholar
  16. 16.
    Wright R, et al. Acetabular fractures: long-term follow-up of open reduction and internal fixation. J Orthop Trauma. 1994;8(5):397–403.PubMedCrossRefGoogle Scholar
  17. 17.
    Marsh JL, et al. Articular fractures: does an anatomic reduction really change the result? J Bone Joint Surg Am. 2002;84-A(7):1259–71.PubMedGoogle Scholar
  18. 18.
    Dirschl DR, et al. Articular fractures. J Am Acad Orthop Surg. 2004;12(6):416–23.PubMedGoogle Scholar
  19. 19.
    Furman BD, Olson SA, Guilak F. The development of posttraumatic arthritis after articular fracture. J Orthop Trauma. 2006;20(10):719–25.PubMedCrossRefGoogle Scholar
  20. 20.
    Rivera JC, et al. Posttraumatic osteoarthritis caused by battlefield injuries: the primary source of disability in warriors. J Am Acad Orthop Surg. 2012;20 Suppl 1:S64–9.PubMedCentralPubMedCrossRefGoogle Scholar
  21. 21.
    Lane NE, et al. OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthritis Cartilage. 2011;19(5):478–82.PubMedCrossRefGoogle Scholar
  22. 22.
    Matta JM. Fractures of the acetabulum: accuracy of reduction and clinical results in patients managed operatively within three weeks after the injury. J Bone Joint Surg Am. 1996;78(11):1632–45.PubMedGoogle Scholar
  23. 23.
    Lewis Jr JS, et al. Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. Arthritis Rheum. 2013;65(3):660–70.PubMedCentralPubMedCrossRefGoogle Scholar
  24. 24.
    Loeser RF, et al. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697–707.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Orthopedic SurgeryDuke University Medical CenterDurhamUSA
  2. 2.Department of Orthopedic SurgeryDuke University Medical CenterDurhamUSA

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