Alzheimer Disease

  • Jill S. GoldmanEmail author


Alzheimer disease (AD) is the most common form of dementia and neurodegenerative disease. Less than 1 % of AD is due to autosomal dominant genes: PSEN 1, PSEN 2, and APP. Susceptibility genes such as APOE contribute to risk in a far larger number of cases. Predictive testing is available for the autosomal dominant genes, but is not recommended for risk genes as they are neither necessary nor sufficient to cause AD. Genetic testing is complicated by capacity to consent, lack of treatment, the need to test an affected family member before predictive testing, and family disagreements about testing.


Genetic Counselor Alzheimer Disease Amyloid Precursor Protein Cerebral Amyloid Angiopathy Mini Mental Status Exam 
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Supplementary material

Early onset familial Alzheimer disease (MOV 324698 kb)


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Taub Institute, Columbia University Medical CenterNew YorkUSA

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