The Muscular Dystrophies

  • Joline DaltonEmail author
  • Jill S. Goldman
  • Jacinda B. Sampson


The muscular dystrophies are heterogeneous group of conditions causing progressive muscle weakness. The dystrophinopathies are caused by mutations in the dystrophin gene, DMD, and include Duchenne muscular dystrophy, Becker muscular dystrophy, and isolated dilated cardiomyopathy. Limb-girdle muscular dystrophies (LGMD) result in progressive proximal muscle weakness and wasting of shoulder and pelvic girdle muscles. The LDMDs are caused by both autosomal dominant and recessive genes. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant condition with scapular winging and slowly progressive muscle weakness. These and several other muscular dystrophies are discussed in this chapter.


Muscular Dystrophy Dystrophin Gene Genetic Counseling Session Becker Muscular Dystrophy Congenital Muscular Dystrophy 
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Supplementary material

Duchenne Muscular Dystrophy Part 1 (MOV 371491 kb)

Duchenne Muscular Dystrophy Part 2 (MOV 314255 kb)


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Joline Dalton
    • 1
    Email author
  • Jill S. Goldman
    • 2
  • Jacinda B. Sampson
    • 3
  1. 1.Paul and Sheila Wellstone Muscular Dystrophy CenterUniversity of MinnesotaMinneapolisUSA
  2. 2.Taub InstituteColumbia University Medical CenterNew YorkUSA
  3. 3.Department of NeurologyColumbia University Medical CenterNew YorkUSA

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