Neuroscience Year pp 149-150 | Cite as
T
Chapter
Abstract
T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins, and the T-cell receptor complex, as well as exchanges of peptide signals between immature lymphocytes and thymic environmental cellular populations. There is now ample evidence that neuropeptide-lymphocyte interactions occur at multiple levels in the thymus, and that the sources of neuropeptides are encountered in different sites such as innervating fibers, stromal cells, and developing thymocytes themselves.
Keywords
Vasoactive Intestinal Peptide Atrial Natriuretic Factor Thymic Epithelial Cell Thymus Gland Vasoactive Intestinal Peptide Receptor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Further reading
- Bellinger DL, Lorton D, Romano TD, Olschowka JA, Feiten SY, Feiten DL (1990): Neuropeptide innervation of lymphoid organs. In: Neuropeptides and Immunopeptides: Messengers in a Neuro-Immune Axis, O’Dorisio MS, Panerai A, eds. Ann NY Acad Sci 594:17–33Google Scholar
- Blalock JE (1989): A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev 69:1–32Google Scholar
- Ericsson A, Geenen V, Robert F, Legros JJ, Vrindts-Gevaert Y, Franchimont P, Brene S, Persson H (1990): Expression of preprotachykinin-A and Neuropeptide-Y messenger RNA in the thymus. Mol Endo 4:1211–1218CrossRefGoogle Scholar
- Geenen V, Robert F, Martens H, et al. (1990): Cellular and molecular aspects of the neuroendocrine-immune dialogue in T-cell differentiation. In: Neuroendocrine Perspectives, vol. 9, MacLeod RM, Müller EE, eds. New York: ElsevierGoogle Scholar
Copyright information
© Springer Science+Business Media New York 1992