Abstract
Hydrochlorothiazide is a diuretic and antihypertensive. Its diuretic action is due to its effect on the renal tubular mechanism of electrolyte reabsorption. The excretion of sodium and chloride occurs in approximately equal amounts and is often accompanied by a loss of potassium and bicarbonate. The mechanism of the antihypertensive action of the thiazides is unknown. Initially cardiac output falls and blood volume is diminished. With chronic therapy the cardiac output returns to normal and the peripheral vascular resistance falls.
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Literature
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© 1982 Springer-Verlag Berlin Heidelberg
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Tallarida, R.J. (1982). Hydrodiuril® (Merck Sharp & Dohme). In: TOP 200. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6746-6_79
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DOI: https://doi.org/10.1007/978-1-4899-6746-6_79
Publisher Name: Springer, New York, NY
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