Relationship of Cingulate Cortex to Schizophrenia and Other Psychiatric Disorders
Abstract
Mental disorders present a unique challenge for neuroscience because they typically alter the way that individuals think, feel, and perceive the external world, while generally sparing motor, sensory, and intellectual functioning. Historically, mental illness has been arbitrarily separated from the mainstream of medicine and research and has been typically referred to as “behavioral” entities. The latter terminology has traditionally carried a pejorative connotation because behavior in humans has been tacitly understood as “willful” in nature and, therefore, of “one’s own doing.” An unfortunate result of this historical trend has been for the psychiatric disorders to be largely ignored by the basic sciences where interests have been directed toward problems with a “sound biological basis.”
Keywords
Anterior Cingulate Cortex GABAergic Interneuron Basket Cell Early Brain Injury Cingulate RegionPreview
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- Altschuler LL, Conrad A, Kovelman J, Scheibel A (1987): Hippocampal pyramidal cell orientation in schizophrenia. A controlled neurohistology study of the Yakovlev collection. Arch Gen Psychiatry 44: 1094–1098Google Scholar
- American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. Washington, D.C., pp 309–313Google Scholar
- Anand BK, Dua S (1956): Circulatory and respiratory changes induced by electrical stimulation of the limbic system (visceral brain). J Neurophysiol 19: 393–400Google Scholar
- Baleydier C, Mauguière F (1980): The duality of the cingulate gyrus in monkey. Neuroanatomical study and functional hypothesis. Brain 130: 525–554Google Scholar
- Ballantine HT, Cassidy WL, Flanagan NW, Marino R (1967): Stereotaxic anterior cingulotomy for neuropsychiatric illness and intractable pain. J Neurosurg 26: 488–495Google Scholar
- Barrelet L, Ferrero F, Szogethy L, Giddey C, Pellizzer G (1990): Expressed emotion and first-admission schizophrenia nine-month follow-up in a French cultural environment. Br J Psychiatry 156: 357–362Google Scholar
- Barris RW, Schumann HR (1953): Bilateral anterior cingulate gyrus lesions. Syndrome of the anterior cingulate gyri. J Neurol 3: 44–52Google Scholar
- Benes FM (1988): Post-mortem structural analyses of schizophrenic brain. Study designs and the interpretation of data. Psychiatr Dev 6: 213–226Google Scholar
- Benes FM (1989): Myelination of cortical-hippocampal relays during late adolescence: Anatomical correlates to the onset of schizophrenia. Schizophr Bull 15: 585–594Google Scholar
- Benes FM (1991): Toward a neurodevelopmental understanding of schizophrenia and other psychiatric disorders. In: Developmental Psychopathology, Cicchetti D, ed. Hillsdale, NJ: ErlbaumGoogle Scholar
- Benes FM, Bird ED (1987): An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. Arch Gen Psychiatry 44: 608–616Google Scholar
- Benes FM, Davidson J, Bird ED (1986): Quantitative cytoarchitectural studies of schizophrenic cortex. Arch Gen Psychiatry 43: 31–35Google Scholar
- Benes FM, Majocha R, Bird ED, Marrotta CA (1987): Increased vertical axon numbers in cingulate cortex of schizophrenics. Arch Gen Psychiatry 44: 1017–1021Google Scholar
- Benes FM, McSparren, Bird ED, SanGiovanni JP, Vincent SL (1991): Deficits in small inter-neurons in prefrontal and cingulate cortex of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 48: 996–100Google Scholar
- Benes FM, Sorensen I, Vincent SL, Bird ED, Sathi M. (1992a): Increased density of glutamate-immunoreactive vertical processes in superficial laminae of cingulate cortex of schizophrenic brain. Cereb Cortex, 2: 503–512Google Scholar
- Benes FM, Vincent SL, Alsterberg G, Bird ED, SanGiovanni JP (1992b): Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics. J Neurosci 12: 924–929Google Scholar
- Benes FM, Vincent SL, SanGiovanni JP (1989): High resolution imaging of receptor binding in analyzing neuropsychiatric disease. BioTechniques 7: 970–979Google Scholar
- Berman KF, Zec RF, Weinberger DR (1986): Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: II. Role of neuroleptic treatment, attention, and mental effort. Arch Gen Psychiatry 43: 126–135Google Scholar
- Berman KF, Zec RF, Weinberger DR (1988): Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. Arch Gen Psychiatry 45: 612–622Google Scholar
- Bird ED, Spokes EGS, Iversen LL (1979): Increased dopamine concentration in limbic areas of brains from patients dying from schizophrenia. Brain 102: 347–360Google Scholar
- Bleuler E (1950): Dementia Praecox or the Group of Schizophrenias. New York: Int PressGoogle Scholar
- Bogerts B, Falkai P, Tutsch J (1986): Cell numbers in the pallidum and hippocampus of schizophrenics. In: Biological Psychiatry, Shagass C, et al., eds. Amsterdam: Elsevier, Vol 27, pp 1178–1180Google Scholar
- Bogerts B, Meertz E, Schonfieldt-Bausch R (1985): Basal ganglia and limbic system pathology in schizophrenia: A morphometric study of brain volume and shrinkage. Arch Gen Psychiatry 42: 784–791Google Scholar
- Brown MH, Lighthill JA (1968): Selective anterior cingulotomy: A psychosurgical evaluation. J Neurosurg 29: 513–519Google Scholar
- Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L (1986): Post-mortem evidence for structural brain changes in schizophrenia. Differences in brain weight, temporal horn area and parahippocampal gyrus width as compared with affective disorder. Arch Gen Psychiatry 43: 36–42Google Scholar
- Callaway E, Naghdi S (1982): An information processing model for schizophrenia. Arch Gen Psychiatry 39: 339–347Google Scholar
- Cameron N (1938): Reasoning, regression and communication in schizophrenics. Psychol Monogr 50: 1–33Google Scholar
- Carlsson A (1978): Mechanism of action of neuroleptic drugs. In: Psychopharmacology: A Generation of Progress, Lipton MA, et al., eds. New York: Raven Press, pp 1057–1070Google Scholar
- Christison GW, Casanova M, Weinberger DR, Rawlings R, Kleinman JE (1989): A quantitative investigation of hippocampal pyramidal cell size, shape, and variability of orientation in schizophrenia. Arch Gen Psychiatry 46: 1027–1032Google Scholar
- Conti F, Fabri M, Manzoni T (1988): Glutamate-positive corticortical neurons in the somatic sensory areas I and II of cats. J Neurosci 8: 294–296Google Scholar
- Corsellis JAN (1976): Psychoses of obscure pathology. In: Greenfield’s Neuropathology, Blackwood W, Corsellis JAN, eds. Chicago: Edward Arnold Publishers, pp 903–915Google Scholar
- Coyle JT (1983): Neurotoxic action of kainic acid. J Neurochem 4: 1–11Google Scholar
- Cross AJ, Crow TJ, Owen F (1979): 7-Amino-butyric acid in the brain in schizophrenia. Lancet 1: 560–561Google Scholar
- Damasio AR, Van Hoesen GW (1983): Emotional disturbances associated with focal lesions of the limbic frontal lobe. In: Neuropsychology of Human Emotion, Heilman KM, Satz P, eds. New York: Guilford Press, pp 85–110Google Scholar
- Deakin JF, Slater P, Simpson MD, Gilchrist AC, Skan WI, Royston MC, Reynolds GP, Cross AJ (1989): Frontal cortical and left temporal glutamaterigic dysfunction in schizophrenia. J Neurochem 52: 1781–1786Google Scholar
- Delay J, Deniker P (1952): Trente-huit cas de psychoses traitées par la cure prolongée et continue de 4500 R.P. In: Neurol, Le Congres Des et al., eds. Masson, ParisGoogle Scholar
- Detre TP, Jarecki HG (1971): Modem Psychiatrie Treatment. Philadelphia: Lippincott, p 108Google Scholar
- Dunsmore RH, Lennox MA (1950): Stimulation and strychnization of supracallosal anterior cingulate gyrus. J Neurophysiol 13: 207–213Google Scholar
- Fairen A, DeFelipe J, Regidor J (1984): Nonpyramidal neurons. Cerebral Cortex 1: 201–253Google Scholar
- Falkai P, Bogerts B (1986): Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatr Neurol Sci 236: 154–161Google Scholar
- Falkai P, Bogerts B, Rozumek M (1988): Cell loss and volume reduction in the entorhinal cortex of schizophrenics. Biol Psychiatry 24: 515–521Google Scholar
- Glees P, Cole J, Whitty WM, Cairns H (1950): The effects of lesions in the cingular gyrus and adjacent areas in monkeys. J Neurol Neurosurg Psychiatry 13: 178–190Google Scholar
- Goldman-Rakic PS (1981): Development and plasticity of primate frontal association cortex. In: The Organization of the Cerebral Cortex, Schmitt FO, ed. Cambridge, MA: MIT Press pp 69–100Google Scholar
- Goldman-Rakic PS, Leranth C, Williams SM, Mons N, Geffard M (1990): Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex. Proc Natl Acad Sci USA 86: 9015–9019Google Scholar
- Hanada S, Mita T, Nishinok N, Tanaka C (1987): 3H-muscinol binding sites is increased in autopsied brains of chronic schizophrenics. Life Sci 40: 259–266Google Scholar
- Heckers S, Heinsen H, Heinsen Y, Beckmann H (1990): Limbic structures and lateral ventricle in schizophrenia. Arch Gen Psychiatry 47: 1016–1022Google Scholar
- Herkenham M (1988): Receptor autoradiography: Optimizing anatomical resolution. In: Receptor Localization Ligand Autoradiography, Leslie FM, Altar CA, eds. New York: Liss, pp 37–38Google Scholar
- Holzman PS, Kringlem E, Matthysse S, Flanagan S, Lipton R, Cramer G, Levin S, Lange K, Levy DL (1988): A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Arch Gen Psychiatry 45: 641–647Google Scholar
- Jacobsen B, Kinney DK (1975): Perinatal complications in adopted and non-adopted schizophrenics and their controls: Preliminary results. Acta Psychiatr Scand 238: 103–123Google Scholar
- Jacoby A, Winkler H (1927): Encephalographischen Studien an Schizophrenen. Arch Psychiatr Nervenkr 84: 208–226Google Scholar
- Jakob H, Beckmann H (1986): Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transmi 65: 303–326Google Scholar
- Jeste D, Lohr JB (1989): Hippocampal pathologic findings in schizophrenia. Arch Gen Psychiatry 46: 1019–1024Google Scholar
- Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L (1976): Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 2: 924–926Google Scholar
- Jones EG (1984): Laminar distribution of cortical efferent cells. In: Cellular Components of the Cerebral Cortex. New York: Plenum, pp 521–554Google Scholar
- Jones EG, Hendry SHC (1984): Basket cells. In: Cerebral Cortex, Peters A, Jones EG, eds. New York: Plenum, Vol 1, pp 309–336Google Scholar
- Jones EG, Powell TPS (1970): An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain 93: 793–820Google Scholar
- Kaada BR, Pribram KH, Epstein JA (1940): Respiratory and vascular responses in monkeys from temporal pole, insula, orbital surface and cingulate gyrus. J Neurophysiol 12: 347–356Google Scholar
- Kennard MA (1955): The cingulate gyrus in relation to consciousness. J Nerv Ment Dis 121: 34–39Google Scholar
- Kety SS (1985): Schizotypal personality disorder. An operational definition of Bleuler’s latent schizophrenia. Schizophr Bull 11: 590–594Google Scholar
- Kety SS, Matthysse S (1972): Prospects for research on schizophrenia. An overview. Neurosci Res Bull 10: 456–467Google Scholar
- Kety SS, Rosenthal D, Wender PH, Schulsinger S (1968): The type and prevalence of mental illness in the biological and adoptive families, of adopted schizophrenics. In: The Transmission of Schizophrenia, Rosenthal D, Kety SS, eds. Oxford: PergamonGoogle Scholar
- Klein DF, Zitrin CM, Woerner M (1978): Antidepressants, anxiety, panic and phobia. In: Psychopharmacology: A Generation of Progress, Lipton MA, Dimascio A, Killam KF, eds. New York: Raven Press, pp 1401–1410Google Scholar
- Kornetsky C, Orzack MH (1978): Physiological and behavioral correlates of attention dysfunction in schizophrenia patients. J Psychiatr Res 14: 69–79Google Scholar
- Kovelman JA, Scheibel AB (1984): A neurohistological correlate of schizophrenia. Biol Psychiatry 19: 1601–1621Google Scholar
- Kraeplin E (1919): Dementia Praecox and Paraphrenia. Edinburg: LivingstoneGoogle Scholar
- Laplane D, Degos JD, Baulac M, Gray F (1981): Bilateral infarction of the anterior cingulate gyri and of the fornices. J Neurol Sci 51: 289–300Google Scholar
- Lindvall O, Björklund A (1984): General organization of cortical monoamine systems. In: Monoamine Innervation of Cerebral Cortex, Descarries L, Reader JR, Jasper HH, eds. New York: Liss, pp 9–40Google Scholar
- Long CJ, Pueschel K, Hunter SE (1978): Assessment of the effects of cingulate gyrus lesions by neuropsychological techniques. J Neurosurg 49: 264–271Google Scholar
- Luria AR (1973): The Working Brain. New York: Basic Books, pp 147–160Google Scholar
- Maas JW (1975): Biogenic amines and depression: Biochemical and pharmacological separation of two types of depression. Arch Gen Psychiatry 32: 1357–1361Google Scholar
- MacLean PD (1954): Studies on limbic system (“visceral brain”) and their bearing on psychosomatic problems. In: Recent Developments in Psychosomatic Medicine, Wittkower ER, Cleghorn RA, eds. Philadelphia: Lippincott, pp 101–125Google Scholar
- MacLean PD (1985): Brain evolution relating to family, play and the separation cell. Arch Gen Psychiatry 42: 405–417Google Scholar
- MacLean PD (1990): The Triune Brain in Evolution. New York: Plenum, pp 242–243Google Scholar
- Majocha R, Marotta C, Benes F (1985): Immunostaining of neurofilament protein in human post-mortem cortex. A sensitive and specific approach to the pattern analysis of human cortical cytoarchitecture. Can J Biochem 63: 577–584Google Scholar
- Malenka RC, Hamblin MW, Barchas JD (1989): Biochemical hypothesis of affective disorders and anxiety. In: Basic Neurochemistry, Molecular, Cellular, and Medical Aspects, Siegel GL, ed. New York: Raven PressGoogle Scholar
- Marco E, Mao CC, Revuelta A, Peralta E, Costa E (1978): Turnover rates of γ-laminobutryric acid in substantia nigra, n. caudatus, globus pallidus and n. accumbens of rats injected with cataleptogenic and non-cataleptogenic antipsychotics. Neuropharmacology 17: 589–596Google Scholar
- Marin-Padilla M (1970a): Prenatal and early postnatal ontogenesis of the human motor cortex: A Golgi study. I. The sequential development of the cortical layers. Brain Res 23: 167–183Google Scholar
- Marin-Padilla M (1970b): Prenatal and early postnatal ontogenesis of the human motor cortex. A Golgi study. II. The basket-pyramidal system. Brain Res 23: 185–191Google Scholar
- Marin-Padilla M (1984): Neurons of layer I. A Developmental analysis. In: Cerebral Cortex, Peters A, Jones EG, eds New York: Plenum Vol 1, pp 447–478Google Scholar
- Matussek P (1951): Untersuchunger über die Wahnwahrnemung. I. Mitteilung: Verangerunger der Wahrenhmungswelt bei beginnenden, primaren Wahn. Arch Psychiatr Nervenkr 189: 279–319Google Scholar
- McGhie A, Chapman J (1961): Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34: 103–116Google Scholar
- Mesulam M-M (1983): The functional anatomy and hemispheric specialization of directed attention. The role of the parietal lobe and its commentary. Trends Neurosci 6: 384–387Google Scholar
- Mesulam M-M, Geschwind N (1978): On the possible role of neocortex and its limbic connections in the process of attention and schizophrenia: Clinical cases of inattention in man and experimental anatomy in monkey. J Psychiatr Res 249–259Google Scholar
- Monaghan DT, Cotman CW (1985): Distribution of N-methyl-D-aspartate-sensitive L-3H-glutamate-binding sites in rat brain. J Neurosci 5: 2909–2919Google Scholar
- Mountcastle VB (1979): An organizing principle for cerebral function: The unit module and the distributed system. In: The Neurosciences: Fourth Study Program, Schmitt FO, Worden FG, eds. Cambridge, MA: MIT Press, pp 21–42Google Scholar
- Mountcastle VB, Lynch JC, Georgopoulos A, Sakata H, Acuna C (1975): Posterior parietal association cortex of the monkey: Command functions for operations within extrapersonal space. J Neurophysiol 38: 871–908Google Scholar
- Nielsen JM, Jacobs LL (1951): Bilateral lesions of the anterior cingulate gyri—report of a case. Bull Los Angeles Neurol Soc 18: 231–238Google Scholar
- Onteniente B, Simon H, Taghzouti K, Geffard M, Moal ML, Calas A (1987): Dopamine-GABA interactions in the nucleus accumbens and lateral septum of the rat. Brain Res 421: 391–396Google Scholar
- Palacios JM, Probst A, Cortes R (1986): Mapping receptors in human brain. Trends Neurosci 9: 284–289Google Scholar
- Pandya DN, Kuypers HG (1969): Cortico-cortical connections in the rhesus monkey. Brain Res 13: 13–36Google Scholar
- Papez JW (1937): A proposed mechanism of emotion. Arch Neurol Psychiatry 38: 725–743Google Scholar
- Pardo JV, Pardo PJ, Janer KW, Raichle ME (1990): The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci USA 87: 256–259Google Scholar
- Parnas J, Schulsinger F, Teasdale W, Schulsinger H, Feldman PM, Mednick SA (1982): Perinatal complications and clinical outcome. Br J Psychiatry 140: 416–420Google Scholar
- Payne RW, Matussek P, George El (1961): Experimental study of schizophrenic thought disorder. Br J Psychiatry 108: 362–367Google Scholar
- Perry TL, Buchanan J, Kish SJ, Hansen S (1979): γ-Aminobutyric acid deficiency in brains of schizophrenic patients. Lancet 1: 237Google Scholar
- Peters A (1984): Chandelier cells. In: Cerebral Cortex, Peter A, Jones EG, eds. New York: Plenum, Vol 1, pp 361–380Google Scholar
- Petras JM (1971): Connections of the parietal lobe. J Psychiatr Res 8: 189–201Google Scholar
- Ploog DW (1979): Phonation, emotion, cognition with reference to the brain mechanisms involved. In: Brain and Mind, Amsterdam: Excerpta Medica, Ciba Found Ser 69, pp 79–98Google Scholar
- Posner MK, Early TS, Reisman E, Pardo PJ, Dhawan M (1988): Asymmetries in hemispheric control of attention in schizophrenia. Arch Gen Psychiatry 45: 814–821Google Scholar
- Rakic P (1975): Timing of major ontogenetic events in the visual cortex of the rhesus monkey. In: Brain Mechanisms of Mental Retardation, Buchwald NA, Brazier M, eds. New York: Academic Press, pp 3–40Google Scholar
- Rakic P (1981): Developmental events leading to laminar and area organization of the neocortex. In: The Organization of the Cerebral Cortex, Schmitt FO, ed. Cambridge, MA: MIT Press, pp 7–28Google Scholar
- Roberts E (1972): An hypothesis suggesting that there is a defect in the GABA system in schizophrenia. Neurosci Res Bull 10: 469–482Google Scholar
- Roberts GW, Colter N, Lofthouse R, Bogerts B, Zec M, Crow TJ (1986): Gliosis in schizophrenia. A survey. Biol Psychiatry 21: 1043–1050Google Scholar
- Rothman SM, Olney JW (1986): Glutamate and the pathology of ischaemic/hypoxic brain damage. Ann Neurol 19: 105–111Google Scholar
- Saccuzzo DP, Braff DL (1986): Information-processing abnormalities: Trait- and state-dependent component. Schizophr Bull 12: 447–456Google Scholar
- Sapolsky RM (1986): Glucocorticoid toxicity in the hippocampus: Reversal by supplementation with brain fuels. J Neurosci 6: 2240–2244Google Scholar
- Schildkraut J, Kety S (1967): Biogenic amines and emotion. Science 156: 21–30Google Scholar
- Seltzer B, Pandya DN (1978): Afferent cortical connections and architectonics of the superior temporal sulcus and surrounding cortex in the rhesus monkey. Brain Res 192: 1–24Google Scholar
- Seltzer B, Pandya DN (1984): Further observations on parieto-temporal connections in the rhesus monkey. Exp Brain Res 55: 301–312Google Scholar
- Seltzer B, Van Hoesen GW (1979): A direct inferior parietal lobule projection to the presubiculum in the rhesus monkey. Brain Res 179: 157–161Google Scholar
- Sidman R, Rakic P (1973): Neuronal migration with special reference to developing human brain. Brain Res 62: 1–35Google Scholar
- Sillito AM (1984): Functional considerations of the operation of GABAergic inhibitory processes in the visual cortex. In: Cerebral Cortex, Jones EG, Peters A, eds. New York: Plenum, pp 91–118Google Scholar
- Simpson MD, Slater P, Deakin JF, Royston MC, Skan WJ (1989): Reduced GABA uptake sites in the temporal lobe in schizophrenia. Neurosci Lett 107: 211–215Google Scholar
- Slotnick BM (1967): Disturbances of maternal behavior in the rat following lesions of the cingulate cortex. Behaviour 24: 204–236Google Scholar
- Smith WD (1945): The functional significance of the rostral cingular cortex as revealed by its responses to electrical excitation. J Neurophysiol 8: 241–255Google Scholar
- Somogyi P, Cowey A (1984): Double bouquet cells. In: Cerebral Cortex, Peter A, Jones EG, eds. New York: Plenum, Vol I, pp 337–360Google Scholar
- Stamm JS (1955): The function of the median cerebral cortex in maternal behavior of rats. J Comp Physiol Psychol 48: 347–356Google Scholar
- Steiner HX, McBean GJ, Kohler C, Roberts PJ, Schwarcz R (1984): Ibotenate-induced neuronal degeneration in immature rat brain. Brain Res 307: 117–124Google Scholar
- Stevens JR (1973): An anatomy of schizophrenia? Arch Gen Psychiatry 29: 177–189Google Scholar
- Suddath RL, Christison GW, Torrey EF (1990): Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New Engl J. Med 322: 789–794Google Scholar
- Tow PW, Whitty CWM (1953): Personality changes after operations on the cingulate gyrus in man. J Neurol Neurosurg Psychiatry 16: 186–193Google Scholar
- Ulinski PS (1990): The cerebral cortex of reptiles. In: Cerebral Cortex, Comparative Structure and Evolution of Cerebral Cortex, Part 1, Jones EG, Peters A, eds. New York: Plenum, Vol 8A, pp 139–215Google Scholar
- Van Hoesen GW (1982): The parahippocampal gyrus. Trends Neurosci 5: 345–350Google Scholar
- van Praag HM (1978): Amine hypotheses of affective disorders. In: Handbook of Psychopharmacology, Iversen SD, Snyder SH, eds. New York: Plenum, Vol 13, pp 187–297Google Scholar
- Vincent S, Sorensen I, Benes FM (1991): Localization and high resolution imaging of cortical neurotransmitter compartments using confocal laser scanning microscopy. GABA and glutamate interactions in rat cortex. J Biotech 11: 628–635Google Scholar
- Vogt BA, Townes-Anderson E, Bums DL (1987): Dissociated cingulate neurons morphology and muscarinic receptors. J Neurosci 7: 959–971Google Scholar
- Vogt O (1952): Proposition de fonder une organisation internationale pour l’étude de l’anatomic pathologiuqe de la schizophrénie et d’autres psychoses dites fonctionelles. Proc Int Cong Neuropathol, 1st, Torino, pp 674–677Google Scholar
- Vonsattel JP, Myers R, Stevens T, Ferrante R, Bird ED, Richardson EP (1985): Neuropathological classification of Huntington’s disease. J Neuropathol Exp Neurol 44: 559–577Google Scholar
- Ward AA (1948a): The anterior cingulate gyrus and personality. In: The Frontal Lobes Baltimore, MD: Williams & Wilkins pp 438–445Google Scholar
- Ward AA (1948b): The cingular gyrus: Area 24. J Neurophysiol 11: 13–23Google Scholar
- Weinberger DR (1987): Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660–669Google Scholar
- Weinberger DR, Berman KF, Zec RF (1986): Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43: 114–124Google Scholar
- Whitehouse PJ, Wamsley JK, Zarbin MA, Price DL, Tourtelotte WW, Kuhar MJ (1983): Amyotrophic lateral sclerosis — alterations in neurotransmitter receptors. Ann Neurol 14: 8–16Google Scholar
- Windle WF, Becker RF (1944): Alterations in brain structure after asphyxiation at birth. J Neuropathol Exp Neurol 3: 224–238Google Scholar
- Yakovlev P, Lecours A (1967): The myelinogenetic cycles of regional maturation of the brain. In: Regional Development of the Brain Early in Life, Minkowski A, ed. Blackwell: Oxford, pp 3–70Google Scholar
- Young WS, Kuhar MJ (1979): A new method for receptor autoradiography: [3H]opioid receptors in rat brain. Brain Res 179: 225–270Google Scholar
- Zhang WQ, Rogers BC, Tandon P, Hudson PM, Sobotka TJ, Hong JS, Tilson HA (1990): Systemic administration of kainic acid increases GABA levels in perfusate from the hippocampus of rats in vivo. Neurotoxicology 11: 593–600Google Scholar