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Epithelial Injury and Repair

  • Elizabeth L. Aronsen
  • John M. Shannon
Chapter
  • 50 Downloads

Abstract

Since the mid-1970s, increasing attention has been paid to the biological responses of alveolar epithelial type II cells following acute lung injury and their contribution to the syndrome of acute respiratory distress in adults (ARDS) [1]. Research has been greatly aided by techniques developed to isolate and culture type II cells in an environment separated from the complex milieu of the whole lung. In addition, application of molecular biological techniques to the study of these cells has rapidly expanded our understanding of the type II cell’s role in the structure and function of the alveolus, which will improve our knowledge of the mechanism by which a diverse group of risk factors can lead to the common final endpoint which is called ARDS, and may result in the development of specific therapies and interventions by which it can be treated [2,3].

Keywords

Acute Lung Injury Alveolar Epithelial Cell Adult Respiratory Distress Syndrome Surfactant Protein Alveolar Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ashbaugh, D.G., Bigelow, C.B., Petty, T.L. and Levine, B.E. (1967) Acute respiratory distress in adults. Lancet, ii, 319–23.Google Scholar
  2. 2.
    Goldstein, G. and Luce, J.M. (1990) Pharmacologic treatment of the adult respiratory distress syndrome. Clin. Chest Med., 11, 773–87.PubMedGoogle Scholar
  3. 3.
    Jacobs, E.R. and Bone, R.C. (1986) Therapeutic implications of acute lung injury. Crit. Care Clin., 2, 615–28.PubMedGoogle Scholar
  4. 4.
    Tomashefski, J.F. Jr (1990) Pulmonary pathology of the adult respiratory distress syndrome. Clin. Chest Med., 11, 593–619.PubMedGoogle Scholar
  5. 5.
    Adamson, I.Y.R. and Bowden, D.H. (1974) The type 2 cell as progenitor of alveolar epithelial regeneration. Lab. Invest., 30, 35–42.PubMedGoogle Scholar
  6. 6.
    Weibel, E.R. (1983) How does the lung affect gas exchange? Chest, 83, 657–65.PubMedGoogle Scholar
  7. 7.
    Albertine, K.H. (1985) Ultrastructural abnormalities in increased-permeability pulmonary edema. Clin. Chest Med., 6, 345–69.PubMedGoogle Scholar
  8. 8.
    Blennerhassett, J.B. (1985) Shock lung and diffuse alveolar damage: pathological and pathogenetic considerations. Pathology, 17, 239–17.PubMedGoogle Scholar
  9. 9.
    Hasleton, P.S. (1983) Adult respiratory distrss syndrome — a review. Histopathology, 7, 307–32.PubMedGoogle Scholar
  10. 10.
    Joka, T., Obertacke, U., Atay, Z. et al. (1989) Cytological changes in alveolar cells with ARDS. Prog. Clin. Biol. Res., 308, 51–5.PubMedGoogle Scholar
  11. 11.
    Riede, U.N., Mittermayer, C., Friedburg, H. et al. (1979) Morphologie development of human shock lung. Pathol. Res. Pract., 165, 269–86.PubMedGoogle Scholar
  12. 12.
    Riede, U.N. and Shah, I. (1984) Diagnostic morphometry of the adult respiratory distress syndrome. Pathol. Res. Pract., 179, 204–6.PubMedGoogle Scholar
  13. 13.
    Barrios, R., Inoue, S. and Hogg, J.C. (1977) Intercellular junctions in ‘shock lung’. A freeze-fracrure study. Lab. Invest., 36, 628–35.PubMedGoogle Scholar
  14. 14.
    Kinnula, V.L., Chang, L., Everitt, J.I. and Crapo, J.D. (1992) Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells. Am. J. Physiol., 262, 69–77.Google Scholar
  15. 15.
    Clyde, B.L., Chang, L.Y., Auten, R.L. et al. (1993) Distribution of manganese superoxide dismutase mRNA in normal and hyperoxic rat lung. Am. J. Respir. Cell Mol Biol, 8, 530–7.PubMedGoogle Scholar
  16. 16.
    Smith, L.J. and Brody, J.S. (1981) Influence of methylprednisolone on mouse alveolar type 2 cell response to acute lung injury. Am. Rev. Respir. Dis., 123, 459–64.PubMedGoogle Scholar
  17. 17.
    Sugiyama, K.L. and Kawai, T. (1993) Diffuse alveolar damage and acute interstitial pneumonitis: histochemical evaluation with lectins and monoclonal antibodies against surfactant apoprotein and collagen type IV. Mod. Pathol, 6, 242–8.PubMedGoogle Scholar
  18. 18.
    Yazdy, A.M., Tomashefski, J.F. Jr, Yagan, R. and Kleinerman J. (1989) Regional alveolar damage (RAD): a localized counterpart of diffuse alveolar damage. Am. J. Clin. Pathol, 92, 10–15.PubMedGoogle Scholar
  19. 19.
    Aerts, C., Wallaert, B. and Voisin C. (1992) In vitro effects of hyperoxia on alveolar type II pneumocytes: inhibition of glutathione synthesis increases hyperoxic cell injury. Exp. Lung Res., 18, 845–61.PubMedGoogle Scholar
  20. 20.
    Gil, J. and McNiff, J.M. (1982) Early tissue damage in ethchlorvynol-induced alveolar edema in rabbit lung. Am. Rev. Respir. Dis., 126, 701–7.PubMedGoogle Scholar
  21. 21.
    Idell, S., James, K.K., Levin, E.G. et al. (1989) Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J. Clin. Invest., 84, 695–705.PubMedGoogle Scholar
  22. 22.
    Seeger, W., Hubel, J., Klapettek, K. et al. (1991) Procoagulant activity in bronchoalveolar lavage of severely traumatized patients — relation to the development of acute respiratory distress. Thromb. Res.61, 53–64.PubMedGoogle Scholar
  23. 23.
    Berggren, P., Lachmann, B., Curstedt, T. et al. (1986) Gas exchange and lung morphology after surfactant replacement in experimental adult respiratory distress syndrome induced by repeated lung lavage. Acta Anaesthesiol. Scand., 30, 321–8.PubMedGoogle Scholar
  24. White, C.W., Ghezzi, P. and Dinarello, CA. et al. Recombinant tumor necrosis factor/ cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia. J. Clin. Invest., 79, 1868–73.Google Scholar
  25. 25.
    Lamm, W.J. and Albert, R.K. (1990) Surfactant replacement improves lung recoil in rabbit lungs after acid aspiration. Am. Rev. Respir. Dis., 142 1279–83.PubMedGoogle Scholar
  26. 26.
    Schuster, D.P. (1994) ARDS: clinical lessons from the oleic acid model of acute lung injury. Am.]. Respir. Crit. Care Med., 149, 245–60.Google Scholar
  27. 27.
    Barrett, C.R. Jr, Bell, A.L. Jr and Ryan, S.F. (1979) Alveolar epithelial injury causing respiratory distress in dogs: physiologic and electron-microscopic correlations. Chest, 75, 705–11.PubMedGoogle Scholar
  28. 28.
    Lewis, J.F, Ikegami, M. and Jobe, A.H. (1990) Altered surfactant function and metabolism in rabbits with acute lung injury. J. Appl. Physiol., 69, 2303–10.PubMedGoogle Scholar
  29. 29.
    Gross, N.J. (1991) Surfactant subtypes in experimental lung damage: radiation pneumonitis. Am. J. Physiol., 260, L302–10.Google Scholar
  30. 30.
    van Daal, G.J., Eijking, E.P. and So, K.L. et al. (1992) Acute respiratory failure during pneumonia induced by Sendai virus. Adv. Exp. Med. Biol, 316, 319–26.PubMedGoogle Scholar
  31. 31.
    Jenkins, J., Carey, P., Byrne, K. et al. (1991) Sepsis-induced lung injury and the effects of ibuprofen pretreatment. Analysis of early alveolar events via repetitive bronchoalveolar lavage. Am. Rev. Respir. Dis., 143, 155–61.PubMedGoogle Scholar
  32. 32.
    Parsons, P.E., Fowler, A.A., Hyers, T.M. and Henson, P.M. (1985) Chemotactic activity in bronchoalveolar lavage fluid from patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis., 132, 490–3.PubMedGoogle Scholar
  33. 33.
    Jacobs, R.F., Tabor, D.R., Burks, A.W. and Campbell, G.D. (1989) Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory distress syndrome. Am. Rev. Respir. Dis., 140, 1686–92.PubMedGoogle Scholar
  34. 34.
    Hallgren, R., Samuelsson, T. and Modig, J. (1987) Complement activation and increased alveolar-capillary permeability after major surgery and in adult respiratory distress syndrome. Crit. Care Med., 15, 189–93.PubMedGoogle Scholar
  35. 35.
    Hallgren, R., Samuelsson, T., Venge, P. and Modig, J. (1987) Eosinophil activation in the lung is related to lung damage in adult respiratory distress syndrome. Am. Rev. Respir. Dis., 135, 639–42.PubMedGoogle Scholar
  36. 36.
    Robbins R.A., Russ, W.D., Rasmussen, J.K. and Clayton, M.M. (1987) Activation of the complement system in the adult respiratory distress syndrome. Am. Rev. Respir. Dis., 135, 651–8.PubMedGoogle Scholar
  37. 37.
    Idell, S., Kucich, U. and Fein, A. et al. (1985) Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis., 132, 1098–105.PubMedGoogle Scholar
  38. 38.
    McGuire, W.W., Spragg, R.G., Cohen, A.B. and Cochrane, C.G. (1982) Studies on the pathogenesis of the adult respiratory distress syndrome. J. Clin. Invest., 69, 543–53.PubMedGoogle Scholar
  39. 39.
    Braude, S., Apperley, J., Krausz, T. et al. (1985) Adult respiratory distress syndrome after allogeneic bone-marrow transplantation: evidence for a neutrophil-independent mechanism. Lancet i, 239–42.Google Scholar
  40. 40.
    Ognibene, F.P., Martin, S.E., Parker, M.M., et al. (1986) Adult respiratory distress syndrome in patients with severe neutropenia. N. Engl. J. Med., 315, 547–51.PubMedGoogle Scholar
  41. 41.
    Cochrane, C.G., Spragg, R.G. and Revak, S.D. et al. (1983) The presence of neutrophil elas-tase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis., 127, 525–7.Google Scholar
  42. 42.
    Haagsman, H.P. and van Golde, L.M. (1985) Lung surfactant and pulmonary toxicology. Lung, 163, 275–303.PubMedGoogle Scholar
  43. 43.
    Lachmann, B. (1989) Animal models and clinical pilot studies of surfactant replacement in adult respiratory distress syndrome. Eur. Respir. J. [Suppl.], 3 98s-103s.Google Scholar
  44. 44.
    Duane, P.G., Rubins, J.B., Weisel, H.R. and Janoff, E.N. (1993) Identification of hydrogen peroxidase as a Streptococcus pneumoniae toxin for rat alveolar epithelial cells. Infect. Immun., 61, 4392–7.PubMedGoogle Scholar
  45. 45.
    Pacht, E.R., Timerman, A.P., Lykens, M.G. and Merola, A.J. (1991) Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome. Chest, 100, 1397–403.PubMedGoogle Scholar
  46. 46.
    Katsura, K., Kawada, H. and Konno, K. (1993) Rat surfactant apoprotein A (SP-A) exhibits antioxidant effects on alveolar macrophages. Am. J. Respir. Cell Mol. Biol. , 9 520–5.PubMedGoogle Scholar
  47. 47.
    Horowitz, S., Watkins, R.H. and Auten, R.L. Jr et al. (1991) Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung. Am. J. Respir. Cell Mol. Biol, 5, 511–5.PubMedGoogle Scholar
  48. 48.
    Nash, J., McLaughlin, P., Hoyle, C. and Roberts, D. (1991) Immunolocalization of tumour necrosis factor alpha in lung tissue from patients dying with adult respiratory distress syndrome. Histopathology, 19, 395–402.PubMedGoogle Scholar
  49. 49.
    Lewis-Molock, Y., Suzuki, K., Taniguchi, N. et al. (1994) Lung manganese superoxide dis-mutase increases during cytokine-mediated protection against pulmonary oxygen toxicity in rats. Am. J. Respir. Cell Mol. Biol, 10, 133–44.PubMedGoogle Scholar
  50. 50.
    Braude, S., Nolop, K.B., Hughes, J.M. et al. (1986) Comparison of lung vascular and epithelial permeability indices in the adult respiratory distress syndrome. Am. Rev. Respir. Dis., 133, 1002–5.PubMedGoogle Scholar
  51. 51.
    Coates, G. and O’Brodovich, H. (1986) Measurement of pulmonary epithelial permability with 99mTc-DTPA aerosol. Semin. Nucl. Med., 16, 275–84.PubMedGoogle Scholar
  52. 52.
    Rinaldo, J.E., Borovetz, H.S., Mancini, M.C et al. (1986) Assessment of lung injury in the adult respiratory distrss syndrome using multiple dilution curves. Am. Rev. Respir. Dis., 133, 1006–10.PubMedGoogle Scholar
  53. 53.
    Tennenberg, S.D., Jacobs, M.P and Solomkin, J.S. (1987) Complement-mediated neutrophil activation in sepsis- and trauma-related adult respiratory distress syndrome. Clarification with radioaerosol lung scans. Arch. Surg., 122, 26–32.PubMedGoogle Scholar
  54. 54.
    Tennenberg, S.D., Jacobs, M.P. and Solomkin, J.S. et al. (1987) Increased pulmonary alveolar-capillary permeability in patients at risk for adult respiratory distress syndrome. Crit. Care Med., 15, 289–93.PubMedGoogle Scholar
  55. 55.
    Matthay, M.A. and Wiener-Kronish, J.P. (1990) Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am. Rev. Respir. Dis., 142, 1250–7.PubMedGoogle Scholar
  56. 56.
    Eiermann, G.J., Dickey, B.F. and Thrall, R.S. (1983) Polymorphonuclear leukocyte participation in acute oleic-acid-induced lung injury. Am. Rev. Respir. Dis., 128, 845–50.PubMedGoogle Scholar
  57. 57.
    Hall, S.B., Notter, R.H., Smith, R.J. and Hyde, R.W. (1990) Altered function of pulmonary surfactant in fatty acid lung injury. J. Appl. Physiol., 69, 1143–9.PubMedGoogle Scholar
  58. 58.
    Holter, J.F., Weiland, J.E. and Pacht, E.R. et al. (1986) Protein permeability in the adult respiratory distrss syndrome. Loss of size selectivity of the alveolar epithelium. J. Clin. Invest., 78, 1513–22.PubMedGoogle Scholar
  59. 59.
    Byrne, K., Carey, P.D., Sielaff, T.D. et al. (1991) Ibuprofen prevents deterioration in static transpulmonary compliance and transalveolar protein flux in septic porcine acute lung injury. J. Trauma, 31, 155–64.PubMedGoogle Scholar
  60. 60.
    Matthay, M.A., Eschenbacher, W.L. and Goetzl, E.J. (1984) Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. J. Clin. Immunol, 4, 479–83.PubMedGoogle Scholar
  61. 61.
    Taylor, L., Polgar, P., McAteer, J.A. and Douglas, W.H.J. (1979) Prostaglandin production by type II alveolar epithelial cells. Biochim. Biophys. Acta, 572, 502–8.PubMedGoogle Scholar
  62. 62.
    Suarez, M. and Krieger, B.P. (1986) Bronchoal-veolar lavage in recurrent aspirin-induced adult respiratory distress syndrome. Chest, 90, 452–3.PubMedGoogle Scholar
  63. 63.
    Hallman, M., Maasilta, P., Sipila, I. and Tahva-nainen, J. (1989) Composition and function of surfactant in adult respiratory distress syndrome. Eur. Respir.]. [Suppl.], 3, 104s-108s.Google Scholar
  64. 64.
    Weaver, T.E. (1988) Pulmonary surfactant-associated proteins. Gen. Pharmacol, 19, 361–8.PubMedGoogle Scholar
  65. 65.
    Kuan, S.F., Rust, K. and Crouch, E. (1992) Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage. J. Clin. Invest., 90 97–106.PubMedGoogle Scholar
  66. 66.
    Wright, J.R. and Dobbs, L.G. (1991) Regulation of pulmonary surfactant secretion and clearance. Annu. Rev. Physiol., 53, 395–414.PubMedGoogle Scholar
  67. 67.
    Brown, L.S. and Longmore, W.J. (1981) Adrenergic and cholinergic regulation of lung surfactant secretion in the isolated perfused rat lung and in the alveolar type II cell in culture. J. Biol. Chem., 256, 66–72.PubMedGoogle Scholar
  68. 68.
    Sano, K., Voelker, D.R. and Mason, R.J. (1987) Tetradecanoylphorbol acetate and terbutaline stimulate surfactant secretion in alveolar type II cells without changing the membrane potential. Biochim. Biophys. Acta, 902, 317–26.PubMedGoogle Scholar
  69. 69.
    Brown, L.S. and Wood, L.H. (1989) Stimulation of surfactant secretion by vasopressin in primary cultures of adult rat type II pneumo-cytes. Biochim. Biophys. Acta, 1001, 76–81.PubMedGoogle Scholar
  70. 70.
    Oyarzun, M.J. and Clements, J.A. (1978) Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit. Am. Rev. Respir. Dis., 117, 879–91.PubMedGoogle Scholar
  71. 71.
    Wirtz, H. and Schmidt, M. (1992) Ventilation and secretion of pulmonary surfactant. Clin. Invest. , 70, 3–13.Google Scholar
  72. 72.
    Chander, A. (1989) Regulation of lung surfactant secretion by intracellular pH. Am. J. Physiol., 257, L354–60.Google Scholar
  73. 73.
    Burkhardt, R., Von Wiehert. P, Batenburg, J.J. and Van Golde, L.M. (1988) Fatty acids stimulate phosphatidylcholine synthesis and CTP: choline-phosphate cy tidy lyltransf erase in type II pneumocytes isolated from adult rat lung. Biochem. J., 254, 495–500.PubMedGoogle Scholar
  74. 74.
    Gilfillan, A.M. and Rooney, S.A. (1985) Ara-chidonic acid metabolites stimulate phosphatidylcholine secretion in primary cultures of type II pneumocytes. Biochim. Biophys. Acta, 833, 336–41.PubMedGoogle Scholar
  75. 75.
    Wali, A., Beers, M.F. and Dodia, C. et al. ATP and adenosine 3′, 5′-cyclic monophosphate stimulate the synthesis of surfactant protein A in rat lung. Am. J. Physiol., 264, L431–7.Google Scholar
  76. 76.
    Rannels, D.E. and Ranneis, S.R. (1989) Influence of the extracellular matrix on type 2 cell differentiation. Chest, 96, 165–73.PubMedGoogle Scholar
  77. 77.
    Shannon, J.M., Jennings, S.D. and Nielsen, L.D. (1992) Modulation of alveolar type II cell differentiated function in vitro. Am. J. Physiol., 262, L427–36.Google Scholar
  78. 78.
    Shannon, J.M., Mason, R.J. and Jennings, S.D. (1987) Functional differentiation of alveolar type II epithelial cells in vitro: effects of cell shape, cell — matrix interactions, and cell-cell interactions. Biochim. Biophys. Acta, 931, 143–56.PubMedGoogle Scholar
  79. 79.
    Dobbs, L.G., Wright, J.R. and, Hawgood, S. et al. (1987) Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells. Proc. Natl Acad. Sei. USA, 84, 1010–4.Google Scholar
  80. 80.
    Chander, A. and Sen, N. Inhibition of phosphatidylcholine secretion by stilbene disulfo-nates in alveolar type II cells. Biochem. Pharmacol., 45, 1905–12.Google Scholar
  81. 81.
    Lewis, J.F. and Jobe, A.H. (1993) Surfactant and the adult respiratory distress syndrome. Am. Rev. Respir. Dis., 147, 18–33.Google Scholar
  82. 82.
    Seeger, W., Günther, A., Walmrath, H.D. et al. (1993) Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects. Clin. Invest., 71, 177–90.Google Scholar
  83. 83.
    Wichert, P. and Kohl, F.V. (1977) Decreased dipalmitoyllecithin content found in lung specimens from patients with so-called shock-lung. Intensive Care Med., 3, 27–30.PubMedGoogle Scholar
  84. 84.
    Hallman, M., Spragg, R. and Harrell, J.H. et al. (1982) Evidence of lung surfactant abnormality in respiratory failure. J. Clin. Invest., 70, 673–83.PubMedGoogle Scholar
  85. 85.
    Pison, U., Seeger, W., Buchhorn, R. et al. (1989) Surfactant abnormalities in patients with respiratory failure after multiple trauma. Am. Rev. Respir. Dis.140, 1033–9.PubMedGoogle Scholar
  86. 86.
    Gregory, T.J., Longmore, W.J., Moxley M.A., et al. (1991) Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J. Clin. Invest., 88, 1976–81.PubMedGoogle Scholar
  87. 87.
    von Wiehert, P., Weigers, U. and Stephan, W. et al. (1978) Altered metabolism of phospholp-ids in the lung of rats with peritonitis. Res. Exp. Med. , 172, 223–9.Google Scholar
  88. 88.
    Wilke, A., Muller, B. and von Wiehert, P. (1987) Ambroxol increases the choline but not the fatty acid incorporation into lung phospholipids in experimental lung disorders. Respiration, 52, 129–36.PubMedGoogle Scholar
  89. 89.
    Petty, T.L., Silvers, G.W., Paul, G.W. and Stanford, R.E. (1979) Abnormalities in lung elastic properties and surfactant function in adult respiratory distress syndrome. Chest, 75, 571–4.PubMedGoogle Scholar
  90. 90.
    Idell, S. and Cohen, A.B. (1985) Bronchoalvear lavage in patients with the adult respiratory distress syndrome. Clin. Chest Med., 6, 459–71.PubMedGoogle Scholar
  91. 91.
    Holm, B.A. and Matalon, S. (1989) Role of pulmonary surfactant in the development and treatment of adult respiratory distress syndrome. Anesth. Analg., 69, 805–18.PubMedGoogle Scholar
  92. 92.
    Jacobson, W., Park, G., Saich, T. and Holcroft, J. (1993) Surfactant and the adult respiratory distress syndrome. Br. J. Anaesth., 70, 522–6.PubMedGoogle Scholar
  93. 93.
    Mason, R.J. (1987) Surfactant in adult respiratory distress syndrome. Eur. J. Respir. Dis., 153, 229–36.Google Scholar
  94. 94.
    Casals, C., Herrera, L., Miguel, E. et al. (1989) Comparison between intra- and extracellular surfactant in respiratory distress induced by oleic acid. Biochim. Biophys. Acta, 1003, 201–3.PubMedGoogle Scholar
  95. 95.
    King, R.J., Coalson, J.J., Seidenfeld, J.J. et al. (1989) O2 and pneumonia-induced lung injury. II. Properties of pulmonary surfactant. J. Appl. Physiol., 67 357–65.PubMedGoogle Scholar
  96. 96.
    Rauvala, H. and Hallman, M. (1984) Glyco-lipid accumulation in bronchoalveolar space in adult respiratory distress syndrome. J. Lipid Res., 25, 1257–62.PubMedGoogle Scholar
  97. 97.
    Kuroki, Y., Gasa, S., Ogasawara, Y. et al. (1992) Binding specificity of lung surfactant protein SP-D for glucosylceramide. Biochem. Biophys. Res. Commun., 187 963–9.PubMedGoogle Scholar
  98. 98.
    Pison, U., Obertacke, U., Seeger, W. and Haw-good, S. (1992) Surfactant protein A (SP-A) is decreased in acute parenchymal lung injury associated with polytrauma. Eur. J. Clin. Invest., 22, 12–8.Google Scholar
  99. 99.
    Gross, N.J. (1991) Inhibition of surfactant subtype convertase in radiation model of adult respiratory distress syndrome. Am. J. Physiol., 260, L311–7.Google Scholar
  100. 100.
    Minoo, P., King R.J. and Coalson, J.J. (1992) Surfactant proteins and lipids are regulated independently during hyperoxia. Am. J. Physiol., 263 291–8.Google Scholar
  101. 101.
    Massaro, D., Thet, L.A., Massaro, G.D. and Frank L. (1980) hypothesis relating breathing pattern to some forms of the ‘adult respiratory distress syndrome’. Am. J. Med., 69, 113–5.PubMedGoogle Scholar
  102. 102.
    Li, J.J., Bramlet, S.G., Carter, E.A. and Burke J.F. (1991) The rat lung organotypic culture: an in vitro model for studying surfactant metabolism abnormalities. J. Trauma, 31, 174–81.PubMedGoogle Scholar
  103. 103.
    O’Brodovich, H.M., Weitz, J.I. and Possmayer, F. (1990) Effect of fibrinogen degradation products and lung ground substance on surfactant function. Biol. Neonate, 57, 325–33.PubMedGoogle Scholar
  104. 104.
    Vadas, P. (1984) Elevated plasma phospholipase A2 levels: correlation with the hemodynamic and pulmonary changes in Gram-negative septic shock. J. Lab. Clin. Med., 104, 873–81.PubMedGoogle Scholar
  105. 105.
    Stommer, P. and Steinmann, U. (1989) Phos-pholipase A2 induced diffuse alveolar damage — effect of indomethacin and dexamethasone upon morphology and plasma-histamine level. Klin. Wochenschr., 67, 171–6.PubMedGoogle Scholar
  106. 106.
    Cockshutt, A.M. and Possmayer F. (1991) Lysophosphatidylcholine sensitized lipid extracts of pulmonary surfactant to inhibition by serum proteins. Biochim. Biophys. Acta, 1086, 63–71.PubMedGoogle Scholar
  107. 107.
    Guy, J., Dhanireddy, R. and Mukherjee, A.B. (1992) Surfactant-producing rabbit pulmonary alveolar cells synthesize and secrete an antiinflammatory protein, uteroglobin. Biochem. Biophys. Res. Commun., 189, 662–9.PubMedGoogle Scholar
  108. 108.
    Dobbs, L.G. (1989) Pulmonary surfactant. Ann. Rev. Med., 40, 431–46.PubMedGoogle Scholar
  109. 109.
    Lachmann, B. (1989) Surfactant therapy. Resuscitation, 18, S37–49.Google Scholar
  110. 110.
    Merritt, T.A., Hallman, M., Spragg, R. et al. (1989) Exogenous surfactant treatments for neonatal respiratory distrss syndrome and their potential role in the adult respiratory distress syndrome. Drugs, 38, 591–611.PubMedGoogle Scholar
  111. 111.
    Richman, P.S., Spragg, R.G., Robertson, B et al. (1989) The adult respiratory distress syndrome: first trials with surfactant replacement. Eur. Respir. J. [Suppl], 3, 109s-llls.Google Scholar
  112. 112.
    Spragg, R.G., Richman, P., Gilliard, N. et al. (1989) The use of exogenous surfactant to treat patients with acute high-permeability lung edema. Prog. Clin. Biol. Res., 308, 791–6.PubMedGoogle Scholar
  113. 113.
    van Daal, G.J., So, K.L. and Gommers, D. et al. (1991) Intratracheal surfactant administration restores gas exchange in experimental adult respiratory distress syndrome associated with viral pneumonia. Anesth. Analg., 72, 589–95.PubMedGoogle Scholar
  114. 114.
    Pinkerton, K.E., Lewis, J., Mulder, A.M. et al. (1993) Surfactant treatment effects on alveolar type II cell morphology in rabbit lungs. J. Appl. Physiol., 74, 1240–7.PubMedGoogle Scholar
  115. 115.
    Lewis, J.F., Ikegami, M. and Jobe, A.H. (1990) Metabolism of exogenously administered surfactant in the acutely injured lungs of adult rabbits. Am. Rev. Respir. Dis., 145, 19–23.Google Scholar
  116. 116.
    Merritt, T.A., Strayer, D.S., Hallman, M et al. (1988) Immunologic consequences of exogenous surfactant administration. Semin. Perina-tol., 12, 221–30.Google Scholar
  117. 117.
    Suzuki, Y., Robertson, B., Fujita, Y. and Grossman, G. (1988) Respiratory failure in mice caused by a hybridoma making antibodies to the 15 kDa surfactant apoprotein. Acta Anaes-thesiol. Scand., 32, 283–9.Google Scholar
  118. 118.
    Eijking, E.P., Strayer, D.S., van Daal, G.J. and Lachmann, B. (1991) Effects of antisurfactant antibodies on the course of mild respiratory distress syndrome. Pathobiology, 59, 96–101.PubMedGoogle Scholar
  119. 119.
    Kuhn, C. 3rd, (1991) Patterns of lung repair. A morphologist’s view. Chest, 99, 11S-14S.Google Scholar
  120. 120.
    Marinelli, W.A., Henke, C.A., Harmon, K.R. et al. (1990) Mechanisms of alveolar fibrosis after acute lung injury. Clin. Chest Med., 11, 657–672.PubMedGoogle Scholar
  121. 121.
    Snyder, L.S., Hertz, M.I., Harmon, K.R. and Bitterman, PB. (1990) Failure of lung repair following acute lung injury. Regulation of the fibroproliferative response (Part 1). Chest, 98, 733–8.PubMedGoogle Scholar
  122. 122.
    Kuhn, C. 3rd, Boldt, J., King, J.T.E. et al. (1989) An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis. Am. Rev. Respir. Dis., 140, 1693–703.PubMedGoogle Scholar
  123. 123.
    Christner, P., Fein, A., Goldberg, S. et al. (1985) Collagenase in the lower respiratory tract of patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis., 131, 690–5.PubMedGoogle Scholar
  124. 124.
    Raghu, G., Striker, L.J., Hudson, L.D. and Striker, G.E. (1985) Extracellular matrix in normal and fibrotic human lungs. Am. Rev. Respir. Dis., 131, 281–9.PubMedGoogle Scholar
  125. 125.
    Griffin, M., Bhandari, R. and Hamilton, G. et al. (1993) Alveolar type II cell-fibroblast interactions, synthesis and secretion of surfactant and type I collagen. J. Cell Sei., 105, 423–32.Google Scholar
  126. 126.
    Leslie, C.C., McCormick-Shannon, K. and Mason, R.J. (1990) Heparin-binding growth factors stimulate DNA synthesis in rat alveolar type II cells. Am. J. Respir. Cell Mol. Biol, 2 99–106.PubMedGoogle Scholar
  127. 127.
    Leslie, C.C., McCormick-Shannon, K., Robinson, P.C. and Mason, R.J. (1985) Stimulation of DNA synthesis in cultured rat alveolar type II cells. Exp. Lung Res., 8 53–66.PubMedGoogle Scholar
  128. 128.
    Mescher, E.J., Dobbs, L.G. and Mason, R.J. (1983) Cholera toxin stimulates secretion of saturated phosphatidylcholine and increases cellular cyclic AMP in isolated rat alveolar type II cells. Exp. Lung Res., 5, 173–82.PubMedGoogle Scholar
  129. 129.
    Leslie, C.C., McCormick-Shannon, K. and Mason, R.J. (1989) Bronchoalveolar lavage fluid from normal rats stimulates DNA synthesis in rat alveolar type II cells. Am. Rev. Respir. Dis. 139 360–6.PubMedGoogle Scholar
  130. 130.
    Fraslon, C. and Bourbon, J. (1992) Comparison of effects of epidermal and insulin-like growth factors, gastrin releasing peptide and retinoic acid on fetal lung cell growth and maturation in vitro. Biochim. Biophys. Acta, 1123, 65–75.Google Scholar
  131. 131.
    Mason, R., Leslie, C., McCormick-Shannon, K., et al. (1994) Hepatocyte growth factor is a growth factor for rat alveolar type II cells. Am. J. Respir. Cell Mol. Biol, 11, 561–7.PubMedGoogle Scholar
  132. 132.
    Lin, C.Q. and Bisseil, M.J. (1993) Multi-faceted regulation of cell differentiation by extracellular matrix. FASEB J., 7, 737–43.PubMedGoogle Scholar
  133. 133.
    Pilewski, J. and Abelda, S. (1993) Adhesion molecules in the lung. An overview. Am. Rev. Respir. Dis., 148, S31–7.Google Scholar
  134. 134.
    Sugahara, K., Kiyota, T., Clark, R.A. and Mason, R.J. (1993) The effect of fibronectin on cytoskeletal structure and transepithelial resistance of alveolar type II cells in primary culture. Virchows Arch. [B], 64, 115–22.Google Scholar
  135. 135.
    Palmgren, M.S., deShazo, R.D., Carter, R.M. et al. (1992) Mechanisms of neutrophil damage to human alveolar extracellular matrix: the role of serine and metalloproteases. J. Allergy Clin. Immunol, 89, 905–15.PubMedGoogle Scholar
  136. 136.
    Kang, B.H., Crapo, J.D., Wegner, C.D. et al. (1993) Intercellular adhesion molecule-1 expression on the alveolar epithelium and its modification by hyperoxia. Am. J. Respir. Cell Mol Biol, 9, 350–5.PubMedGoogle Scholar
  137. 137.
    Christensen, P.J., Kim, S., Simon, R.H. et al. (1993) Differentiation-related expression of ICAM-1 by rat alveolar epithelial cells. Am. J. Respir. Cell Mol Biol, 8, 915.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1996

Authors and Affiliations

  • Elizabeth L. Aronsen
  • John M. Shannon

There are no affiliations available

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